Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Gerdle, Björn; Larsson, Björn

doi:10.5772/38822

Cited by 13 publications

(26 citation statements)

References 139 publications

(228 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous review of microdialysis studies in human myalgia and tendon-related conditions (20) and in a review of microdialysis studies specifically focused on chronic muscle pain conditions (22), the authors concluded that 5-HT may potentially be a biomarker of chronic myalgia; we concur with their conclusions. They note that 5-HT can activate nociceptors which transmit pain signals to the central nervous system, and that it may have an algesic or hyperalgesia effect depending on the particular cell and receptor targeted (20).…”

Section: Gold Et Alsupporting

confidence: 70%

“…In the intervening years, literature on biochemical markers of MSD has grown, although very few longitudinal studies have been performed. Recent reviews have highlighted biochemical alterations associated with the pathogenesis of particular MSD in humans or animal models (19)(20)(21)(22). However, a systemic summary of the current state of MSD biomarker research in humans is needed.…”

Section: Previous Biomarker Reviewsmentioning

confidence: 99%

“…They note that 5-HT can activate nociceptors which transmit pain signals to the central nervous system, and that it may have an algesic or hyperalgesia effect depending on the particular cell and receptor targeted (20). Potential involvement of this mechanism in trapezius myalgia should be further examined in longitudinal studies.…”

Section: Gold Et Almentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Gold¹,

Hallman²,

Hellström³

et al. 2015

Scand J Work Environ Health

View full text Add to dashboard Cite

A statistically significant association between the musculoskeletal disorders (MSD) and biomarkers studied was demonstrated in 82% of sufficient quality articles. Evidence suggested that: collagen repair marker (TIMP-1) is decreased in fibroproliferative disorders; serotonin (5-HT) is increased in trapezius myalgia; triglycerides are increased in various MSD. Limitations in the articles include possible selection bias, confounding, spectrum effect, and insufficient attention to comorbid conditions.

show abstract

Section: Gold Et Alsupporting

confidence: 70%

Section: Previous Biomarker Reviewsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Gold¹,

Hallman²,

Hellström³

et al. 2015

Scand J Work Environ Health

View full text Add to dashboard Cite

show abstract

“…Hence, it was not possible to confirm earlier studies of more severe TM [18–24, 53]. The lack of group differences for these algesics may be accounted by the degree of pain severity.…”

Section: Discussionmentioning

confidence: 62%

Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study

Gerdle

Kristiansen

Larsson

et al. 2014

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundThis study compares the levels of algesic substances between subjects with trapezius myalgia (TM) and healthy controls (CON) and explores the multivariate correlation pattern between these substances, pain, and metabolic status together with relative blood flow changes reported in our previous paper (Eur J Appl Physiol 108:657–669, 2010).Methods43 female workers with (TM) and 19 females without (CON) trapezius myalgia were – using microdialysis - compared for differences in interstitial concentrations of interleukin-6 (IL-6), bradykinin (BKN), serotonin (5-HT), lactate dehydrogenas (LDH), substance P, and N-terminal propeptide of procollagen type I (PINP) in the trapezius muscle at rest and during repetitive/stressful work. These data were also used in multivariate analyses together with previously presented data (Eur J Appl Physiol 108:657–669, 2010): trapezius muscle blood flow, metabolite accumulation, oxygenation, and pain development and sensitivity.ResultsSubstance P was significantly elevated in TM (p=0.0068). No significant differences were found in the classical algesic substances (p: 0.432-0.926). The multivariate analysis showed that blood flow related variables, interstitial concentrations of metabolic (pyruvate), and algesic (BKN and K+) substances were important for the discrimination of the subjects to one of the two groups (R2: 0.19-0.31, p<0.05). Pain intensity was positively associated with levels of 5-HT and K+ and negatively associated with oxygenation indicators and IL-6 in TM (R2: 0.24, p<0.05). A negative correlation existed in TM between mechanical pain sensitivity of trapezius and BKN and IL-6 (R2: 0.26-0.39, p<0.05).ConclusionThe present study increased understanding alterations in the myalgic muscle. When considering the system-wide aspects, increased concentrations of lactate, pyruvate and K+ and decreased oxygenation characterized TM compared to CON. There are three major possible explanations for this finding: the workers with pain had relatively low severity of myalgia, metabolic alterations preceded detectable alterations in levels of algesics, or peripheral sensitization and other muscle alterations existed in TM. Only SP of the investigated algesic substances was elevated in TM. Several of the algesics were of importance for the levels of pain intensity and mechanical pain sensitivity in TM. These results indicate peripheral contribution to maintenance of central nociceptive and pain mechanisms and may be important to consider when designing treatments.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2474-15-357) contains supplementary material, which is available to authorized users.

show abstract

“…At a very low flow (ie, 0.3 μL/minute), the recovery is near 100%. Detailed descriptions of relative recovery (RR) can be found elsewhere 81,82,84. Adding dextran or albumin to the perfusate can enhance RR for charged molecules, such as peptides and cytokines.…”

Section: Introductionmentioning

confidence: 99%

Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique

Gerdle¹,

Ghafouri²,

Ernberg³

et al. 2014

JPR

View full text Add to dashboard Cite

Chronic musculoskeletal pain conditions are multifaceted, and approximately 20% of the adult population lives with severe chronic pain, with a higher prevalence in women and in lower income groups. Chronic pain is influenced by and interacts with physical, emotional, psychological, and social factors, and a biopsychosocial framework is increasingly applied in clinical practice. However, there is still a lack of assessment procedures based on the activated neurobiological pain mechanisms (ie, the biological part of the biopsychosocial model of pain), which may be a necessary step for further optimizing outcomes after treatments for patients with chronic pain. It has been suggested that chronic pain conditions are mainly driven by alterations in the central nervous system with little or no peripheral stimuli or nociception. In contrast, other authors argue that such central alterations are driven by peripheral alterations and nociceptive input. Microdialysis is an in vivo method for studying local tissue alterations and allows for sampling of substances in the interstitium of the muscle, where nociceptor free nerve endings are found close to the muscle fibers. The extracellular matrix plays a key role in physiologic functions of cells, including the primary afferent nociceptor. The present review mainly concerns the results of microdialysis studies and how they can contribute to the understanding of activated peripheral nociceptive and pain mechanisms in humans with chronic pain. The primary aim was to review molecular studies using microdialysis for the investigation of human chronic muscle pain, ie, chronic masticatory muscle pain, chronic trapezius myalgia, chronic whiplash-associated disorders, and chronic widespread pain/fibromyalgia syndrome. Several studies clearly showed elevated levels of serotonin, glutamate, lactate, and pyruvate in localized chronic myalgias and may be potential biomarkers. These results indicate that peripheral muscle alterations are parts of the activated pain mechanisms in common chronic pain conditions. Muscle alterations have been reported in fibromyalgia syndrome and chronic widespread pain, but more studies are needed before definite conclusions can be drawn. For other substances, results are inconclusive across studies and patient groups.

show abstract

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Cited by 13 publications

References 139 publications

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study

Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique

Contact Info

Product

Resources

About