The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans

Islam, Saleem; Thomas, Seddon Y.; Hess, Christoph; Medoff, Benjamin D.; Means, Terry K.; Berthou, Christian; Lilly, Craig M.; Tager, Andrew M.; Luster, Andrew D.

doi:10.1182/blood-2005-06-2362

Cited by 67 publications

(50 citation statements)

References 66 publications

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“…These observations are consistent with the view that melatonin favors the early phases of inflammation on one side, in fact, LOX induces the production of leukotriene B, which promotes diapedesis by vessel permeabilization, and acts as a chemo-attractant [92,93]. On the other side, melatonin reduces the inflammatory process when it proceeds towards the chronic phase.…”

Section: Effects Of Melatonin On the Arachidonic Acid Metabolismsupporting

confidence: 90%

Melatonin: A pleiotropic molecule regulating inflammation

Radogna

Diederich

Ghibelli

2010

Biochemical Pharmacology

308

247

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Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves.With its endocrine and paracrine effects, melatonin differentially modulates pro-inflammatory enzymes, controls production of inflammatory mediators such as cytokines and leukotrienes and regulates the lifespan of leukocytes by interfering with apoptotic processes. Moreover, its potent anti-oxidant ability allows scavenging of oxidative stress in the inflamed tissues. The interesting timing of pro-and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation. This review aims at giving a comprehensive overview of the various inflammatory pathways regulated by this pleiotropic hormone.

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Section: Effects Of Melatonin On the Arachidonic Acid Metabolismsupporting

confidence: 90%

Melatonin: A pleiotropic molecule regulating inflammation

Radogna

Diederich

Ghibelli

2010

Biochemical Pharmacology

308

247

View full text Add to dashboard Cite

show abstract

“…Likewise, BLT 1 R mRNA is induced in CD4 ϩ murine lymphocytes during either Th1 or Th2 polarization . A subsequent study of human blood-derived T lymphocytes demonstrated that the small fraction of BLT 1 R-positive cells also were enriched for the activation markers CD38 and HLA-DR and expressed the effector cytokines IFN-␥ and IL-4 (Islam et al, 2006). Furthermore, in vitro activation of human T lymphocytes by alloactivated DCs increased BLT 1 R surface expression and enhanced LTB 4 -induced chemotaxis (Islam et al, 2006).…”

Section: Intracellular Signaling Pathways and Second-messenger Sysmentioning

confidence: 99%

“…Furthermore, in vitro activation of human T lymphocytes by alloactivated DCs increased BLT 1 R surface expression and enhanced LTB 4 -induced chemotaxis (Islam et al, 2006). In further support of an up-regulation of BLT 1 R in activated T lymphocytes, the number of circulating CD8 ϩ cells positive for BLT 1 R was increased during acute Epstein-Barr virus infection (Islam et al, 2006). Finally, bronchoalveolar lavage derived from patients with lung transplant graft dysfunction (Medoff et al, 2005) and asthma (Islam et al, 2006) contained an increased proportion of BLT 1 R-positive T lymphocytes.…”

Section: Intracellular Signaling Pathways and Second-messenger Sysmentioning

confidence: 99%

“…A subsequent study of human blood-derived T lymphocytes demonstrated that the small fraction of BLT 1 R-positive cells also were enriched for the activation markers CD38 and HLA-DR and expressed the effector cytokines IFN-␥ and IL-4 (Islam et al, 2006). Furthermore, in vitro activation of human T lymphocytes by alloactivated DCs increased BLT 1 R surface expression and enhanced LTB 4 -induced chemotaxis (Islam et al, 2006). In further support of an up-regulation of BLT 1 R in activated T lymphocytes, the number of circulating CD8 ϩ cells positive for BLT 1 R was increased during acute Epstein-Barr virus infection (Islam et al, 2006).…”

Section: Intracellular Signaling Pathways and Second-messenger Sysmentioning

confidence: 99%

See 1 more Smart Citation

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Bäck¹,

Dahlén²,

Drazen³

et al. 2011

Pharmacol Rev

130

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“…Importantly, the gene encoding FLAP was recently associated with increased risk of myocardial infarction and stroke, 5 and mechanistic studies have supported the notion of a major role of leukotriene signaling in atherosclerosis. 6 Leukotriene B 4 (LTB 4 ), for example, is among the most potent chemotactic mediators formed within the atherosclerotic lesion, inducing migration of a number different cell types, such as monocytes, 7 vascular smooth muscle cells, 8 and T cells, 9 suggesting LTB 4 as a potential link between innate and adaptive immunological reactions. However, the latter notion has not previously been assessed in the context of atherosclerosis and adipose tissue inflammation.…”

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confidence: 99%