Biochemical Pharmacology volume 80, issue 12, P1844-1852 2010 DOI: 10.1016/j.bcp.2010.07.041 View full text
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Flavia Radogna, Marc Diederich, Lina Ghibelli

Abstract: ABSTRACTMelatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves.With its endocrine and paracrin…

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