The Letter Contrast Sensitivity Test: Clinical Evaluation of a New Design

Haymes, Sharon A.; Roberts, K.F.; Cruess, Alan F.; Nicolela, Marcelo T.; LeBlanc, Raymond P.; Ramsey, Michael S.; Chauhan, Balwantray C.; Artes, Paul H.

doi:10.1167/iovs.05-1419

Cited by 76 publications

(52 citation statements)

References 58 publications

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“…Studies probing the mechanisms of contrast sensitivity require electronic instrumentation, as in Hayes and Merigan (2007), but portable charts based on contrast can be used as a guide to possible deficits that could be subjected to further analysis (Figure 4). The Pelli-Robson and Mars tests use a single large letter size with contrast varying across groups of letters (Haymes et al, 2006). The Pelli-Robson chart uses letters (6 per line), arranged in groups whose contrast varies from high to low.…”

Section: Sensory Endpointsmentioning

confidence: 99%

Chemobrain: A translational challenge for neurotoxicology

Weiss

2008

NeuroToxicology

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Neurotoxicity is a frequent accompaniment of cancer chemotherapy, and held by many oncologists to be the major dose-limiting side effect. It appears in many forms, but attracted attention during the past decade primarily because of complaints by patients of impaired cognitive function they have labeled as "chemobrain". Neuropsychological testing confirmed the validity of these complaints and has generated a substantial literature examining different aspects of cognitive impairment in various clinical populations undergoing a variety of treatments. Cognitive impairment is far from the only manifestation of neurotoxicity induced by chemotherapy, however. It alters sensory function and motor function as well. A critical need for patients is a suite of methods that will enable clinicians to trace the onset and progression of neurotoxicity so as to guide and balance decisions about the course of chemotherapy. This commentary describes some of the potential methods and encourages neurotoxicologists to enlist their unique skills in the service of these needs.

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Section: Sensory Endpointsmentioning

confidence: 99%

Chemobrain: A translational challenge for neurotoxicology

Weiss

2008

NeuroToxicology

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“…Detecting contrast is an essential feature of vision that can provide information about a patient's visual function that is independent of visual acuity (Haymes et al, 2006). Consequently, CS acts as a valuable supplement to traditional visual acuity assessments in both clinical settings and in human engineering applications (Scialfa, Adams, & Giovanetto, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…The incentive for using CS testing in normal vision patients is that contrast detection affects everyday living and bodily health (Haymes et al, 2006). Previous research has shown that good contrast detection facilitates numerous common activities such as driving, reading, walking, performing computer tasks, and recognizing faces (Haymes et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Previous research has shown that good contrast detection facilitates numerous common activities such as driving, reading, walking, performing computer tasks, and recognizing faces (Haymes et al, 2006). A reduction in CS has been shown to inhibit the ability to perform these activities and similar everyday tasks, thereby decreasing overall quality of life (dos Santos & Andrade, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, CS has been used as a tool for diagnosing and monitoring diseases such as glaucoma, cataracts, and optic neuritis (Haymes et al, 2006). For example, CS testing has been used to assess the condition and monitor the progress of stroke patients (dos Santos & Andrade, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Contrast Sensitivity Testing in Visually Normal Individuals: Letter vs. Continuous Text

Davis¹,

Taub²,

Cisarik³

2017

Interprofessional Optometry

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Evaluation of Multiple Neurotoxic Outcomes in Cancer Chemotherapy

Weiss

2010

Chemo Fog

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Although it is now clear that cognitive dysfunction is a common accompaniment of cancer chemotherapy, its implications await further research and direction. Most of the clinical research relies on standard neuropsychological tests that were developed to diagnose stable traits. Cognitive dysfunction in patients undergoing treatment varies with time. Its dimensions will vary during the course of treatment, which generally consists of cycles of drug administration followed by recovery periods. To effectively determine the connection between chemotherapy and cognitive function requires neuropsychological tests based on performance, so that they can be administered at specified times during the entire course of treatment and beyond. A number of computerized test batteries, many of which have been developed for environmental neurotoxicology, are now available that fit such criteria. Moreover, cognitive impairment is only one aspect of chemotherapy-induced neurotoxicity. A full appreciation of its scope requires assessment of sensory functions such as vision, audition, and somatosensory properties, and assessment of motor function. A program of research based on animal models is also essential. Only with animal models is it possible to determine dose-response relationships and to couple behavioral with mechanistic indices such as neuroplasticity. Animal behavior models play a vital role in environmental toxicology because, from them, it is possible to derive some index of exposure that limits adverse effects. However, as in human testing, it is critical to choose situations whose properties remain stable over long periods of time so as to trace the time course of neurotoxicity.

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The Letter Contrast Sensitivity Test: Clinical Evaluation of a New Design

Cited by 76 publications

References 58 publications

Chemobrain: A translational challenge for neurotoxicology

Chemobrain: A translational challenge for neurotoxicology

Contrast Sensitivity Testing in Visually Normal Individuals: Letter vs. Continuous Text

Evaluation of Multiple Neurotoxic Outcomes in Cancer Chemotherapy

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