The Lesson Learned from the COVID-19 Pandemic: Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid

Abstract

The COVID-19 pandemic has underlined the importance of disinfectants as tools to prevent and fight against coronavirus spreading. An ideal disinfectant and sanitizer must be nontoxic to surface contact, noncorrosive, effective, and relatively inexpensive as it is hypochlorous acid (HOCl). The present work intended to evaluate, on different surfaces, the bactericidal and virucidal effectiveness of nebulized HOCl and test its safety usage in 2D and 3D skin and lung models. Our data showed that HOCl at the dose of 300 ppm did not affect cellular and tissue viability, not their morphology. The HOCl bactericidal properties varies with the surface analyzed: 69% for semi-porous, 96–99.9% for flat and porous. This discrepancy was not noticed for the virucidal properties. Overall, this study showed that nebulized HOCl can prevent virus and bacteria growth without affecting lung and skin tissues, making this compound a perfect candidate to sanitize indoor environments.

COVID‐19 and the chemical industry: impacts, challenges, and opportunities

“…By assimilating them into their strategies and operations, chemical companies can emerge as more resilient, sustainable, and socially responsible entities. [96][97][98][99][100][101] Future preparedness requires a proactive and adaptive mindset, a commitment to embracing new technologies, and a willingness to collaborate across sectors and borders. Armed with these valuable lessons, the chemical industry can navigate future uncertainties with greater confidence and make significant contributions to global recovery and progress.…”

“…These lessons along with their associated benefits in the chemical industry are summarized in Table 8. By assimilating them into their strategies and operations, chemical companies can emerge as more resilient, sustainable, and socially responsible entities 96‐101 . Future preparedness requires a proactive and adaptive mindset, a commitment to embracing new technologies, and a willingness to collaborate across sectors and borders.…”

Lifestyle, Nutrition, and Environmental Factors Influencing Health Benefits

“…Hypochlorous acid (HOCl) was suggested by Benedusi et al [ 5 ] as a potential candidate for fighting a variety of microorganisms, including spores and viruses. The findings of this research showed that this HOCl treatment can be regarded as a natural, environmentally friendly disinfectant that is effective in eliminating bacteria and viruses and seems to be safe for human health.…”

Depigmentation of Melanin-containing Tissues Using Hypochlorous Acid to Enhance Hematoxylin-eosin and Immunohistochemical Staining

“…Hypochlorous acid (HClO) disinfectant tablets have been widely utilized since the coronavirus disease 2019 outbreak 11,12 . The HClO is an oxygenated chlorine acid and a potent oxidizing and bleaching agent.…”

“…9,10 Hypochlorous acid (HClO) disinfectant tablets have been widely utilized since the coronavirus disease 2019 outbreak. 11,12 The HClO is an oxygenated chlorine acid and a potent oxidizing and bleaching agent. In addition, HClO is an active ingredient in bleach formulations 13 and a common disinfectant in the medical and industrial sectors and households.…”