The LEPR Gene Is Associated with Reproductive Seasonality Traits in Rasa Aragonesa Sheep

Lakhssassi, Kenza; Serrano, M.; Crespo, Belén Lahoz; Sarto, María Pilar; Iguácel, Laura Pilar; Folch, J.; Alabart, J. L.; Calvo, J.H.

doi:10.3390/ani10122448

Cited by 6 publications

(6 citation statements)

References 53 publications

(77 reference statements)

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“…In our work, LEPR was identified as a candidate gene for the pregnancy rate. This gene has already been associated with several reproduction traits, including pregnancy [67][68][69][70]. The genes GHR and LPAR2 are associated with sheep reproduction [71,72], while DMXL1 is related to reproduction traits in heifers [73].…”

Section: Discussionmentioning

confidence: 99%

Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep

Ramos

Garrick

Blair

et al. 2023

Genes

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The aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE ≥ 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes.

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Section: Discussionmentioning

confidence: 99%

Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep

Ramos

Garrick

Blair

et al. 2023

Genes

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“…In our study, we discovered a relationship between the LEPR gene and such growth parameters as BW56, DCW, BrW, TW, and ADBWG. It should also be noted that a fairly large number of other studies have demonstrated the LEPR gene effects on growth, productivity, and reproduction in various farm animals [ 85 , 86 , 87 , 88 , 89 , 90 , 91 ], including poultry [ 78 , 92 , 93 , 94 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study Revealed Putative SNPs and Candidate Genes Associated with Growth and Meat Traits in Japanese Quail

Volkova,

Romanov,

Abdelmanova

et al. 2024

Genes

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The search for SNPs and candidate genes that determine the manifestation of major selected traits is one crucial objective for genomic selection aimed at increasing poultry production efficiency. Here, we report a genome-wide association study (GWAS) for traits characterizing meat performance in the domestic quail. A total of 146 males from an F2 reference population resulting from crossing a fast (Japanese) and a slow (Texas White) growing breed were examined. Using the genotyping-by-sequencing technique, genomic data were obtained for 115,743 SNPs (92,618 SNPs after quality control) that were employed in this GWAS. The results identified significant SNPs associated with the following traits at 8 weeks of age: body weight (nine SNPs), daily body weight gain (eight SNPs), dressed weight (33 SNPs), and weights of breast (18 SNPs), thigh (eight SNPs), and drumstick (three SNPs). Also, 12 SNPs and five candidate genes (GNAL, DNAJC6, LEPR, SPAG9, and SLC27A4) shared associations with three or more traits. These findings are consistent with the understanding of the genetic complexity of body weight-related traits in quail. The identified SNPs and genes can be used in effective quail breeding as molecular genetic markers for growth and meat characteristics for the purpose of genetic improvement.

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“…Genes, as an integral part of this process, are fundamentally responsible for the regulation of traits. Single trait is intricately regulated by multiple microeffective genes; thus, human exploration of genes has never ceased, and there are numerous studies on reproductive traits [1][2][3][4]. In animal husbandry, elucidating the effects of genes on reproductive traits is important to improve the economic efficiency of breeding.…”

Section: Introductionmentioning

confidence: 99%

SEMA4G targeted by miR‐363‐5p regulates the proliferation of granulosa cells in Yunshang black goats

Chen

Wang

et al. 2023

Animal Research and One Health

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Proliferation of granular cells (GCs) plays an important role in ovary development, providing energy and a microenvironment for oocyte ovulation. In this study, we explored the spatiotemporal expression of SEMA4G and its effects on the growth and development of goat GCs using primary GCs cultured in vitro as a model. The results showed that the expression level of SEMA4G was significantly higher in the ovaries of high‐fertility goats than in those of low‐fertility goats (p < 0.05). The mRNA and protein expression levels of the cell proliferation markers of GCs were significantly increased after the overexpression of SEMA4G in goat primary GCs. The EdU and CCK8 results showed that cell viability was elevated in goat GCs and that proliferation was promoted by an increase in the number of proliferating cells. The proliferation of goat GCs was significantly inhibited by SEMA4G inhibition (p < 0.05). The results of online miRNA and target gene prediction software and dual luciferase activity analysis confirmed that SEMA4G could bind to mi‐363‐5p and was one of its target genes. The RT‒qPCR results showed that the expression level of miR‐363‐5p was significantly lower in the ovaries of high‐fertility goats than in those of low‐fertility goats in contrast to the expression level of SEMA4G (p < 0.05). After the overexpression of miR‐363‐5p in goat GCs, the expression of SEMA4G was significantly suppressed (p < 0.05). Collectively, the results of this study could lay the foundation for exploring the molecular mechanisms by which SEMA4G and miR‐363‐5p regulate the growth and development of goat GCs and provide targets for breeding high‐fertility goats.

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The LEPR Gene Is Associated with Reproductive Seasonality Traits in Rasa Aragonesa Sheep

Cited by 6 publications

References 53 publications

Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep

Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep

Genome-Wide Association Study Revealed Putative SNPs and Candidate Genes Associated with Growth and Meat Traits in Japanese Quail

SEMA4G targeted by miR‐363‐5p regulates the proliferation of granulosa cells in Yunshang black goats

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