The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

Ferdous, Afia; Janta, Rabir Ahmed; Arpa, Rubaiya Nushin; Afroze, Mirola; Khan, Mala; Moniruzzaman, Md.

doi:10.1016/j.jep.2020.113148

Cited by 15 publications

(11 citation statements)

References 69 publications

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“…Pretreatment of animals with methylene blue (as an inhibitor of the cGMP pathway) synergized the antinociceptive effect of MEBS; in contrast, pretreatment with glibenclamide reversed the antinociceptive effect. These results suggest that MEBS have antinociceptive effects, possibly through the modulation of K ATP channels and cGMP ( Ferdous et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“… Ferdous et al (2020) investigated the antinociceptive effects of the methanol extract of Bougainvillea spectabilis leaves (MEBS; 50, 100, and 200 mg/kg, p.o.) on acetic acid-induced writhing in mice.…”

Section: Resultsmentioning

confidence: 99%

“…The antinociceptive effects of medicinal plants HeTA, LPEF, MEBS, MECC, EOZZ, and polymethoxyflavones (active constituents of the methanol extract of N. plumbaginifolia leaves) are linked to the modulation of K ATP channels in six studies ( Khalid et al, 2011 ; Brandão et al, 2013 ; Islam et al, 2016 ; Adeyemi et al, 2018 ; Shajib et al, 2018 ; Ferdous et al, 2020 ). K ATP channels are widely distributed in both the central and peripheral nervous systems.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the effect of medicinal plants or phytochemicals on NO/cGMP signaling was demonstrated in five studies ( Khalid et al, 2011 ; Brandão et al, 2013 ; Islam et al, 2016 ; Adeyemi et al, 2018 ; Ferdous et al, 2020 ). The studies indicated that the antinociceptive effects of medicinal plants or phytochemicals depend on the activation of ATP-dependent K + channels due to the modulation of the NO/cGMP signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, it seems that LPEF exerts its antinociception effect via the opioid/K ATP /L-Arg-NO pathways (Brandão et al, 2013). Ferdous et al (2020) investigated the antinociceptive effects of the methanol extract of Bougainvillea spectabilis leaves (MEBS; 50, 100, and 200 mg/kg, p.o.) on acetic acid-induced writhing in mice.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Rajabian

Babaei

et al. 2022

Front. Pharmacol.

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Potassium ion (K+) channels are pore-forming transmembrane proteins that control the transport of K+ ions. Medicinal plants are widely used as complementary therapies for several disorders. Studies have shown that the modulation of K+ channels is most likely involved in various pharmacological effects of medicinal plants. This review aimed to evaluate the modulatory effects of medicinal plants and their active constituents on K+ channels under pathological conditions. This systematic review was prepared according to the Preferred Reporting Items for the Systematic Reviews and Meta-analyses (PRISMA) 2020 guideline. Four databases, including PubMed, Web of Science, embase, and Scopus, were searched. We identified 687 studies from these databases, from which we selected 13 in vivo studies for the review by using the Population, Intervention, Comparison, Outcomes, Study (PICOS) tool. The results of the 13 selected studies showed a modulatory effect of medicinal plants or their active constituents on ATP-sensitive potassium channels (KATP), and small (SKCa) and large (BKCa) conductance calcium-activated K+ channels in several pathological conditions such as nociception, brain ischemia, seizure, diabetes, gastric ulcer, myocardial ischemia-reperfusion, and hypertension via possible involvement of the nitric oxide/cyclic GMP pathway and protein kinase. K+ channels should be considered as significant therapeutic milestones in the treatment of several diseases. We believe that understanding the mechanism behind the interaction of medicinal plants with K+ channels can facilitate drug development for the treatment of various K+ channel-related disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Rajabian

Babaei

et al. 2022

Front. Pharmacol.

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pH‐responsive gum tragacanth hydrogels for high methylene blue adsorption

Illanes,

Takara,

Masuelli

et al. 2023

J of Chemical Tech & Biotech

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BackgroundBiobased hydrogels are used in many applications due to their easy availability, low cost and versatility to acquire different structures. However, there is scarce information about the changes generated in the matrix's microstructure after crosslinking reactions. The effect of the crosslinking reaction using glutaraldehyde on the micro and macrostructure of tragacanth gum hydrogels (TG GLU) was evaluated.ResultsNew acetal groups, that increase with increasing GLU, produced less packed biopolymeric structures with more thermal stability. Due to demethoxylation, a higher amount of free carboxylic groups after crosslinking reaction were determined in TG GLU. Crosslinked hydrogels presented a higher water uptake capacity with a pH responsive behavior with suitable thermal and mechanical properties. Besides, the highest adsorptive capacity of methylene blue achieved was qm=530 mg/g.ConclusionspH responsible gels from tragacanth were obtained after crosslinking with glutaraldehyde. Chemical and microstructural changes affect the Methylene Blue adsorption, resulting in hydrogels with improved adsorptive properties. These properties give the TG‐GLU hydrogels some features that make them suitable for practical applications related to the pharmaceutical industry for drug delivery and water remediation.This article is protected by copyright. All rights reserved.

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Ornamental plant extracts: Application in food colouration and packaging, antioxidant, antimicrobial and pharmacological potential–A concise review

SG,

Sethi,

et al. 2023

Food Chemistry Advances

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The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways

Cited by 15 publications

References 69 publications

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

pH‐responsive gum tragacanth hydrogels for high methylene blue adsorption

Ornamental plant extracts: Application in food colouration and packaging, antioxidant, antimicrobial and pharmacological potential–A concise review

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