Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Rajabian, Arezoo; Rajabian, Fatemeh; Babaei, Fatemeh; Mirzababaei, Mohammadreza; Nassiri‐Asl, Marjan; Hosseinzadeh, Hossein

doi:10.3389/fphar.2022.831963

Cited by 7 publications

(6 citation statements)

References 70 publications

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“…PGE2 is continuously synthesized by COX in gastric epithelial cells, and its production can be blocked by indomethacin. Potassium-selective ion channels are pore-forming proteins that allow potassium ions (K + ) to pass through the plasma membrane [ 51 ]. It is involved in smooth muscle cell relaxation and gastric mucosal defense, but glyburide inhibits this effect [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

et al. 2022

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Foxtail millet has been traditionally considered to possess gastroprotective effects, but studies evaluating its use as a treatment for gastric ulcers are lacking. Here, we assessed the antiulcer effects of foxtail millet protein hydrolysate (FPH) and explored its mechanism by using blocking agents. In a mouse model of ethanol-induced gastric ulcers, pretreatment with FPH reduced the ulcerative lesion index, downregulated the expression of inflammatory cytokines in the gastric tissue, increased the activity of antioxidant enzymes, and improved the oxidative status. FPH increased constitutive the activity of nitric oxide synthase (cNOS), NO levels, and mucin expression in gastric mucosa, and inhibited the activation of the ET-1/PI3K/Akt pathway. In a mouse model of pyloric ligation-induced gastric ulcers, FPH inhibited gastric acid secretion and decreased the activity of gastric protease. Pretreatment of mice with the sulfhydryl blocker NEM and the NO synthesis inhibitor L-NAME abolished the gastroprotective effect of FPH, but not the KATP channel blocker glibenclamide and the PGE2 synthesis blocker indomethacin. Among the peptides identified in FPH, 10 peptides were predicted to have regulatory effects on the gastric mucosa, and the key sequences were GP and PG. The results confirmed the gastroprotective effect of FPH and revealed that its mechanism was through the regulation of gastric mucosal mucus and NO synthesis. This study supports the health effects of a millet-enriched diet and provides a basis for millet protein as a functional food to improve gastric ulcers and its related oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

et al. 2022

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“…The efficacy of this treatment is equivalent to that of classic medicines, such as carbenoxolone and cimetidine, which are used for treating GMI ( Arunachalam, et al, 2019 ). Furthermore, in some injury models, its efficacy is even better than that of carbenoxolone and cimetidine ( Rajabian, et al, 2022 ). Finally, the efflux of K + ions after opening blocks the voltage-sensitive Ca 2+ channels, which ultimately results in the dilation of blood vessels and improvement of smooth muscle contraction, thereby increasing GMBF.…”

Section: Repairs To the Gmbf Barriermentioning

confidence: 99%

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Jia,

He,

et al. 2023

Front. Pharmacol.

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Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs.Methods: Further basic and translational studies must be done to elucidate the intrinsic mechanisms of influence of these TCM preparations. Moreover, well-designed and well-conducted experiences and clinical trials are necessary to ascertain the efficacy and mechanisms of these agents. Therefore, this paper presents a focused overview of currently published literature to assess how TCMs action that facilitates the cures for GMI. It offers a whole train of current state of pharmacological evidence, identifies the pharmacological mechanisms of TCMs on GM, and highlights that remarkable capacity of TCMs to restore GM after damage.Results: These TCMs preparations promote the repair of multicomponent targets such as the gastric mucus, epithelial layer, blood flow (GMBF) and lamina propria barrier.Summary: Overall, this study has summarized the essential regulatory mechanisms and pharmacological efficacy of TCMs on new and productive therapeutic targets.Discussion: This review provides an avenue for studying various drugs with potentially promising effects on mucosal integrity, as well as subsequent pharmacological studies, clinical applications, and new drug development.

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“…The aim of this study was to find out if Cleosia cristata, could help with depression by looking at its phytochemical, pharmacological, and toxicological properties (Rajabian et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidepressant Activity of Various Extract of Celosia cristata Fruits and Leaves by Using Forced Swim Test

Anjali,

Gangadhar,

et al. 2024

Intern. J. Bio. Env. Invest.

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The components of the plant used in these studies were bought from a store. The fruits and leaves of Cleosia cristata were and then ground into a coarse powder. Ethanol, petroleum ether, and chloroform were used in to remove the chemicals. The dry marks on these parts were mixed with warm distilled water and then filtered. The extractives were evaporated with less pressure. One way to get water extractives was to heat a plate in a ceramic dish and let the water drain on it. Albino mice were used to test the antidepressant effect. There was no plan for picking the creatures. Researchers looked at how ethanol, petroleum ether, chloroform, and water extracts from Cleosia cristata fruits and leaves could help people who are depressed. It was mixed with Tween 80 to hold the dried ingredients, which were then mixed with pure water. Iripramine, the prescribed medication, was taken just as directed. Antidepressant medication was detected using the Forces Swim Test (FST). Half an hour before to the commencement of the test, dosages of 50, 100, 150, and 200 mg/kg of imipramine and other extracts were administered. Each group had a minimum of six animals. Utilising Dunnett's Method and one-way analysis of variance, we compared each extractive separately with imipramine (standard) and the control. P<0.001 was accepted to show that the results were statistically significant.

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Interaction of Medicinal Plants and Their Active Constituents With Potassium Ion Channels: A Systematic Review

Cited by 7 publications

References 70 publications

Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury

Evaluation of Antidepressant Activity of Various Extract of Celosia cristata Fruits and Leaves by Using Forced Swim Test

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