Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

Zhang, Bowei; Rao, Xiaoxiao; Zhang, Yunhui; Dai, Weijia; Xu, Yinbo; Zhao, Chenchen; Chen, Zhenjia; Wang, Jin; Fan, Dancai; Wang, Xiaowen; Wang, Shuo

doi:10.3390/antiox11122459

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Foxtail millet has antiulcer activity through suppressed levels of plasma and mucosal TBARS (Thiobarbituric acid reactive substances) and increased gastric non-protein sulfhydryl (NPSH) digestive enzyme activities ( 100 ). Foxtail millet protein reduced gastric ulcers in mouse models through a down-regulation of inflammatory cytokine expression in gastric tissue and improved oxidative status ( 101 ).…”

Section: Role Of Millets In Correcting Diseases and Lifestyle Disordersmentioning

confidence: 99%

The nutrition and therapeutic potential of millets: an updated narrative review

Jacob,

Krishnan,

Antony

et al. 2024

Front. Nutr.

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Millets are ancient small grains grown in arid and semiarid regions of the world. They are staple food for many people in Asia and Africa. They are abundant sources of minerals and vitamins, giving them the name Nutricereals. Moreover, millets contain valuable phytochemicals that impart therapeutic properties for various disorders and diseases, thus giving them nutraceutical value. A wide array of biochemical compounds are present in the plant parts as well as the grains. In the oldest texts of medicine in India and China, millets are mentioned for use for their medicinal value. There has been expanding interest and emerging facts about millets and their therapeutic uses. Ample evidence shows that consumption of millets amounts to correction of life style and metabolic disorders. Therapeutic properties of millets can be viewed in two ways, supplementary nutrition through minerals and vitamins, and therapeutic value through the presence of phytochemicals and specialty compounds that include flavonoids, phenolics, anthocyanidins and others that have antioxidant potential. Millets are gluten free, have low glycemic index and the phytochemicals aid in correction of lifestyle disorders and prevention of ailments like carcinogenesis. Supplementary benefits include treatment of anemia and calcium deficiency especially for pregnant women and young children. With the improvements in analytical methods for detection of various compounds, it is possible to identify the compound-specific genotypes in millets that can cater to the pharmacy industry. End-use specific genotypes can be bred to meet the demand. Millets being climate resilient, can contribute to a healthier life and better world through economic usage of natural resources.

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Section: Role Of Millets In Correcting Diseases and Lifestyle Disordersmentioning

confidence: 99%

The nutrition and therapeutic potential of millets: an updated narrative review

Jacob,

Krishnan,

Antony

et al. 2024

Front. Nutr.

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“…Troxipide (TRO), also known as 3,4,5-trimethoxy-N-3-piperidinyl, inhibits oxidative stress and neutrophil-mediated inflammation, [5][6][7][8][9] along with enhancing cytoprotective prostaglandins secretion. 10 Due to these properties, TRO is used to treat gastroesophageal reflux disease, and its mechanism may enhance the treatment of severe OM.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters

Kadowaki,

Ogata,

Nishida

et al. 2023

DDDT

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Medical therapies, such as the use of anti-inflammatory agents, are commonly used for the treatment of oral mucositis (OM). However, these treatments have limited efficacy in treating severe cases of OM. In this study, we aimed to develop a carbopol gel incorporating troxipide (TRO) nanoparticles and methylcellulose (TRO-NP gel) and demonstrate its efficacy in accelerating wound healing in a hamster model of OM (OM model) induced by acetic acid injection. Methods: TRO nanoparticles were prepared using bead milling. The crystalline form was determined by powder X-ray diffraction, and the particle size was measured using a NanoSight LM10 instrument. The drug release was determined using a Franz diffusion cell, and the hamsters injected with acetic acid were selected to evaluate the therapeutic effect of OM. Results: After preparing TRO nanoparticles, we observed a mixture of crystals and amorphous TRO, and the particle size of TRO in the TRO-NP gel ranged from 50 to 280 nm. The TRO-NP gel exhibited a more uniform TRO distribution and viscosity compared to the Carbopol gel containing TRO microparticles (TRO-MP gel). However, the solubility of TRO was comparable in both TRO-MP and TRO-NP gels. The TRO-NP gel released a higher amount of TRO than that from the TRO-MP gel, with detectable release of TRO nanoparticles. TRO levels in the cheek pouches of hamsters treated with TRO-NP gel were higher than those treated with TRO-MP gel. The increased TRO levels in the cheek pouches of hamsters treated with TRO-NP gel were attenuated by treatment with 40 μM dynasore, an inhibitor of clathrin-dependent endocytosis (CME). Moreover, the therapeutic effect of the TRO-NP gel was superior to that of the TRO-MP gel in the hamster model of OM. Conclusion:We have designed a TRO-NP gel, and this gel showed excellent TRO delivery into the cheek pouch tissue through the CME pathway. Moreover, the TRO-NP gel treatment enhanced wound healing after acetic acid injection.

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“…And finally, natural phytochemicals extracted from plants are inexpensive, easily accessible, and have less negative effects, making them excellent traditional medicines for the treatment of ulcer disease. [10][11][12] Asia and Africa are two regions where millets are frequently farmed and is the grain that is most commonly consumed in China. A significant portion of human nutrition comes from millets, whose output has been rising over the past few decades to keep up with the growing global population's…”

mentioning

confidence: 99%

Evaluation of Antiulcer Activity for Selective and Functional Millet using Pylorus Ligation Induced Ulcer in Rat

Vanjari,

Kumbhar

2024

IJPQA

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Although millet has long been thought to have gastroprotective properties, much research does not assess its efficacy as a treatment for stomach ulcers. Currently, medication therapy is the primary clinical treatment for stomach ulcers. Antacids, cytoprotective medicines, proton pump inhibitors (PPI), H2 histamine receptor antagonists have many side effect and poor patient compliance. Hence, inexpensive, easily accessible, and with less negative effects, millets are an excellent and traditional source in the treatment of a variety of diseases like ulcers. In the present research, pearl millet, finger millet and sorghum millet formulation is used and toxicity and antiulcer activity are determined on wistar rats grouped in six different groups consisting of control, disease, standard, millet formulation, glycerin (gly.) vehicles and millet along with glycerin vehicle. After the test item was administered once at a solitary dosage of 2000 mg/kg, none of the treatment group animals showed several clinical indications of toxicity or mortality. In antiulcer activity, ulcer scoring was found to be less in group treated with millet and glycerin than in the diseased group and standard group and %inhibition was also increased in groups treated with millet with glycerine. Total acidity and pepsin estimation was done and these values for the millet group with glycerine were found within limit compared to disease control. The millet and glycerine treatment significantly inhibited lesions associated with stomach ulcers.

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Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice

Cited by 7 publications

References 56 publications

The nutrition and therapeutic potential of millets: an updated narrative review

The nutrition and therapeutic potential of millets: an updated narrative review

Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters

Evaluation of Antiulcer Activity for Selective and Functional Millet using Pylorus Ligation Induced Ulcer in Rat

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