The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence

Deacon, Terrence W.; Pakzaban, Peyman; Isacson, Ole

doi:10.1016/0006-8993(94)90526-6

Cited by 211 publications

(128 citation statements)

References 34 publications

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“…In this study, we used growth factor-expanded neural stem and progenitor cells from the LGE, a structure that during embryonic development, generates both the striatal projection neurons and the interneurons of the olfactory bulb (Deacon et al, 1994;Olsson et al, 1998;Wichterle et al, 1999). We have previously reported that although many LGE characteristics are maintained in neurosphere cultures in vitro, the ISL1-expressing striatal progenitor population is not present in these cultures (Parmar et al, 2002).…”

Section: Maintained Potential For Striatal Neuron Differentiation In mentioning

confidence: 99%

“…Striatal projection neurons and olfactory bulb interneurons are derived from the same embryonic structure, the lateral ganglionic eminence (LGE) (Deacon et al, 1994;Olsson et al, 1995Olsson et al, , 1997Olsson et al, , 1998Wichterle et al, 1999Wichterle et al, , 2001. The dopamine and cAMPregulated phosphoprotein (DARPP-32)-expressing striatal projection neurons are generated almost exclusively during the embryonic period (Bayer and Altman, 1995) from a progenitor population in the LGE subventricular zone marked by the expression of the LIM homeodomain protein ISL1 (Thor et al, 1991;Toresson et al, 2000;Toresson and Campbell, 2001;Wang and Liu, 2001;Yun et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Striatal Neuron Differentiation from Neurosphere-Expanded Progenitors Depends onGsh2Expression

Jensen¹,

Björklund²,

Parmar³

2004

J. Neurosci.

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Neural stem and progenitor cells from the embryonic forebrain can be expanded under growth factor stimulation in vitro, either as free-floating aggregates called neurospheres or as attached monolayer cultures. We have previously shown that despite the maintenance of important regulatory genes such as Gsh2, in vitro expansion of cells from the lateral ganglion eminence (LGE) restricts their differentiation potential. Specifically, their ability to differentiate into striatal projection neurons is compromised. It is not clear whether this restriction is caused by loss of progenitors with the ability to generate striatal projection neurons or whether the restricted differentiation potential is caused by factors lacking during in vitro differentiation. To address this, we have set up an in vitro system, in which expanded LGE-derived cells are differentiated in coculture with primary cells isolated from different regions of the embryonic brain. We provide evidence that the primary cells supply the expanded cells with contact-mediated region-specific developmental cues. Neurosphereexpanded LGE progenitors can, when presented with these cues, differentiate into neurons with characteristics of striatal projection neurons. Furthermore, we show that the ability of the expanded LGE cells to respond to the developmental cues presented by the primary cells depends on the maintained expression of Gsh2 in the expanded cells.

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Section: Maintained Potential For Striatal Neuron Differentiation In mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Striatal Neuron Differentiation from Neurosphere-Expanded Progenitors Depends onGsh2Expression

Jensen¹,

Björklund²,

Parmar³

2004

J. Neurosci.

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“…In the same way, the cortico-striatal sulcus is delimited by the telencephalic expression of the Dlx homeotic gene (Bulfone et al, 1993), further evidence at the molecular level of the compartmentalization of this region (Price et al, 1991;Puelles and Rubenstein, 1993;Porteus et al, 1994;AlvarezBolado et al, 1995). Cells derived from the LGE of the rat embryo transplanted into the ST of adult rats developed exclusively striatal phenotypes (Deacon et al, 1994). However, cells from the striatal VZ transplanted at E15 to a cortical environment develop morphologies typical of pyramidal or stellate cortical cells (Fishell, 1995).…”

Section: The Cortico-striatal Sulcus: a Major Boundary Domain?mentioning

confidence: 99%

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

1996

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From previous developmental studies, it has been proposed that the neurons of the ventrolateral cortex, including the primary olfactory cortex, differentiate from progenitor cells in the lateral ganglionic eminence. The objective of the present study was to test this hypothesis. The cells first generated in the forebrain of the rat migrate to the surface of the telencephalic vesicle by embryonic day (E) 12. Using [3 H]thymidine, we found that most of these cells contributed to the formation of the deep layer III of the primary olfactory cortex. To study the migratory routes of these cells, we made localized injections of the carbocyanine fluorescent tracers DiI and DiA into various parts of the lateral ganglionic eminence in living embryos at E12-E14 and subsequently maintained the embryos in a culture device for 17-48 hr. After fixation, most migrating cells were located at the surface of the telencephalic vesicle, whereas others were seen coursing tangentially into the preplate. Injections made at E13 and in fixed tissue at E15 showed that migrating cells follow radial glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral surface of the telencephalic vesicle. The spatial distribution of radial glial fibers was studied in Golgi preparations, and these observations provided further evidence of the existence of long glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral cortex. We conclude that cells of the primary olfactory cortex derive from the lateral ganglionic eminence and that some early generated cells migrating from the lateral ganglionic eminence transgress the cortico-striatal boundary entering the preplate of the neocortical primordium.

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“…Development of the striatum, for example, is thought to involve three sequential steps: (1) production of different classes of projection neurons from the same common progenitor pool in the lateral ganglionic eminence (LGE); (2) radial migration of striatal projection neurons to form a distinct neuronal assemble in the telencephalic mantle; and (3) tangential migration of interneurons from a remote progenitor pool in the medial ganglionic eminence (MGE), which further increases cell diversity within the nucleus (Deacon et al, 1994;Olsson et al, 1995Olsson et al, , 1998Marín et al, 2000;Wichterle et al, 2001;Hamasaki et al, 2003). A similar process has been proposed recently for the generation of some nuclei in the amygdala ).…”

Section: Introductionmentioning

confidence: 99%

Origin and Molecular Specification of Globus Pallidus Neurons

Nóbrega-Pereira¹,

Gelman²,

Bartolini³

et al. 2010

J. Neurosci.

124

157

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The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are generated sequentially from common progenitor cells and migrate radially to reach their final destination, whereas interneurons are generated remotely and arrive to the cortex through tangential migration. Using the globus pallidus as a model to study the formation of forebrain nuclei, we found that the development of this basal ganglia structure involves the generation of several distinct classes of projection neurons from relatively distant progenitor pools, which then assemble together through tangential migration. Our results thus suggest that tangential migration in the forebrain is not limited to interneurons, as previously thought, but also involves projection neurons and reveal that the assembly of forebrain nuclei is more complex than previously anticipated.

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The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence

Cited by 211 publications

References 34 publications

Striatal Neuron Differentiation from Neurosphere-Expanded Progenitors Depends onGsh2Expression

Striatal Neuron Differentiation from Neurosphere-Expanded Progenitors Depends onGsh2Expression

Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat

Origin and Molecular Specification of Globus Pallidus Neurons

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