The Large Intestine as a Reservoir for Escherichia coli Causing Extra-intestinal Infections

Svanborg-Edén, C; Hull, Sheila I.; Leffler, Hakon; Norgren, S.; Plos, K.; Wold, Agnes E.

doi:10.1007/978-1-349-10723-0_4

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…Hospital infections of adult patients with Klebsiella spp., Enterobacter spp., S. aureus and other species producing bacteremia of intestinal ori gin have been frequently described [30], How ever, the neonatal period differs in many aspects from all other periods of life: the immune system is unexperienced and not yet able to effectively handle localized infections which tend to spread throughout the body and often cause septicemia or meningitis [31,32], Moreover, any potentially pathogenic mi croorganism may become pathogenic in the newborn if it increases to high numbers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Preventive Administration of a Nonpathogenic <i>Escherichia coli</i> Strain on the Colonization of the Intestine with Microbial Pathogens in Newborn Infants

1997

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In a randomized, double-blind study, 27 healthy newborn infants were colonized with the nonpathogenic Escherichia coli strain Nissle 1917 (E. coli DSM 6601, Mutaflor®) during the first 5 days of life by daily oral inoculation of 1 ml of a suspension with 108 living cells. A second group of 27 newborns, used as controls, received a placebo suspension (1 ml of phosphate-buffered saline) instead. Stool samples were taken on days 1,2, 3, 5, and 21, and 6 months after birth. All samples were examined for the presence of the nonpathogenic E. coli strain and of pathogenic and potentially pathogenic microorganisms. The administered E. coli strain was detected in the stools of the colonized newborns from day 2 and remained present throughout the study in more than 90% of these infants. Colonization with true and potential bacterial pathogens was significantly reduced in infants receiving E.coli strain Nissle 1917 compared to the placebo group – both with respect to numbers of pathogens and to the spectrum of species.

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Section: Discussionmentioning

confidence: 99%