The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

Orgeta, Vasiliki; Mukadam, Naaheed; Sommerlad, Andrew; Livingston, Gill

doi:10.1017/ipm.2018.4

Cited by 74 publications

(61 citation statements)

References 14 publications

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“…Based on previous studies, we selected age, [25][26][27][28][29] sex, 30 income level, 31 comorbidity, 32 presence of disability 33 and region 31 as covariates affecting the incidence of dementia. The specific definitions of the variables were determined as follows: through a review of previous studies, [25][26][27][28][29] the association between depression and dementia appeared clinically in three age groups, and age was therefore categorised into three groups (≤44 years, 45-64 years and ≥65 years). Income levels, available as deciles in the NHIS-NSC DB, were divided into three categories: low (0-3), middle (4-7) and high (8-10).…”

Section: Other Variablesmentioning

confidence: 99%

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

Jung

et al. 2020

BMJ Open

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ObjectivesDementia is common in people over the age of 65 years, with 80% of people with dementia older than 75 years. Previous studies have linked dementia to late-life depression, but the association between dementia and mid-life depression is poorly understood. Depression is a preventable and treatable medical condition, which means it is a modifiable factor that can potentially prevent or delay dementia. This study aimed to identify the association between dementia and depression within the life course.DesignA nationwide, retrospective propensity score matched cohort study associating dementia with depression. Depression diagnosed between the ages of 45 and 64 years was classified as ‘mid-life’ and ‘late-life’ if diagnosed at 65 years or older. Patients were considered to have depression when one or more International Statistical Classification of Diseases and Related Health Problems, 10th revision codes for depression were recorded as primary or secondary diagnosis.SettingNational Health Insurance Service-National Sample Cohort database of the National Health Insurance Service in South Korea, containing patient data from 2002 to 2013.ParticipantsThe study included 1824 and 374 852 patients in the case and control groups, respectively. A logistic regression analysis with complex sampling design was performed after adjusting for covariates, using the propensity score matching method without callipers, with a 1:1 nearest neighbour matching algorithm.Primary and secondary outcome measuresThe association of mid-onset and late-onset depression with dementia in terms of sociodemographic characteristics, such as sex and age, within the Korean population.ResultsDementia was significantly associated with the presence of depression (OR=2.20, 95% CI=1.53–3.14); in particular, female patients with depression and patients aged 45–64 years with depression had increased odds of dementia (OR=2.65, 95% CI=1.78–3.93 and OR=2.72, 95% CI=1.41–5.24, respectively)ConclusionDepression is an associated factor for dementia, especially among people aged 45–64 years (mid-life).

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Section: Other Variablesmentioning

confidence: 99%

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

Jung

et al. 2020

BMJ Open

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“…A hearing loss as little as a 25 dB was found to be equivalent to the cognitive reduction associated with an age difference of 6.8 years [24] People with mild hearing loss are twice as likely to develop dementia as those without hearing loss and five times more likely to develop it if they have a severe loss [25]. Hearing loss not only increases the risk of developing dementia but accelerates the rate of cognitive decline [26] The Lancet commission on Dementia Prevention, Intervention, and Care describes the new life-course model of dementia prevention incorporating nine modifiable risk factors and their potential effect in reducing an individuals' risk of dementia [27]. They were surprised to find that hearing loss was the largest contributor, almost doubling the risk.…”

Section: Global Disease Burden Of Hearing Lossmentioning

confidence: 99%

The Need to Increase Awareness and Access to Cochlear Implantation

D’Haese¹,

Rompaey²,

Bodt³

et al. 2020

Advances in Rehabilitation of Hearing Loss

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Some degree of disabling hearing loss is present in 466 million people worldwide, representing 5% of the world's population and the majority of these are adults over 65 years old. Hearing loss is associated with increased risks of social isolation, depression, dementia, stroke, vision loss, diabetes and mortality. It is in the top five causes of years lived with disability in 2015, 2016 and 2017 for males and top 10 for females. Hearing aids are a suitable treatment for mild to moderate loses but for some they do not provide enough benefit. Cochlear implantation is a proven and effective treatment for bilateral severe to profound hearing loss, yet despite good funding in high income countries, the utilisation of CI is poor (less than 10% of suitable patients), especially in the older adult population who arguably need it most. Prevalence data shows that hearing loss increases with age, but the provision of implants in the over 65 s is even lower, despite there being no clinical barriers to older adults receiving a CI. Survey data shows that awareness activities are needed for both professionals and the general population to improve knowledge of what a CI is and how it can help.

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“…Contrera et al [13] in their prospective study that enlisted both HA and CI users over the age of 50 years, concluded that CIs were more effective than HA with respect to QoL outcomes, also recognized by others as summarized in the review provided by Schaefer et al [64]. Importantly, hearing loss and its associated effects are considered modifiable with today's technologies [19,28,32,52,53]. Lin [43] provides a comprehensive overview about the pervasive influence of hearing loss on cognition and other domains.…”

Section: Introductionmentioning

confidence: 99%

Healthy aging in elderly cochlear implant recipients: a multinational observational study

et al. 2020

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Background: Given an increase in the aging population and its impact on healthcare systems, policy makers for provision of health and social services are aiming to keep older adults in good health for longer, in other words towards 'healthy aging'. Our study objective is to show that rehabilitation with cochlear implant treatment in the elderly with hearing impairment improves the overall health-related quality of life and general well-being that translate into healthy aging. Methods: The multicentre, prospective, repeated measures, single-subject, clinical observational study will accrue 100 elderly, first-time, unilateral CI recipients (≥ 60 years) and analyze changes on specific measurement tools over ca. 20 months from preimplant to postimplant. Evaluations will consist of details collected through case history and interview questionnaires by clinicians, data logging, self-report questionnaires completed by the recipients and a series of commonly used audiometric measures and geriatric assessment tools. The primary indicator of changes in overall quality of life will be the HUI-3. Discussion: The protocol is designed to make use of measurement tools that have already been applied to the hearing-impaired population in order to compare effects of CI rehabilitation in adults immediately before their implantation, (pre-implant) and after gaining 1-1.5 years of experience (post-implant). The broad approach will lead to a greater understanding of how useful hearing impacts the quality of life in elderly individuals, and thus improves potentials for healthy aging. Outcomes will be described and analyzed in detail. Trial registration: This research has been registered in ClinicalTrials.gov (http://www.clinicaltrials.gov/), 7 March 2017 under the n°NCT03072862.

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The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action

Cited by 74 publications

References 14 publications

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

The Need to Increase Awareness and Access to Cochlear Implantation

Healthy aging in elderly cochlear implant recipients: a multinational observational study

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