The Kohs' blocks test as an important instrument to investigate the visuo-spatial impairments in myotonic dystrophy: part I. Quantitative and qualitative analysis

Wigg, Cristina Maria Duarte; Duro, Luiz Antonio Alves

doi:10.1590/s0004-282x1999000400002

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…Also notable was the less marked impairment in visuospatial as compared to verbal skills. This contrasts with other reported cases of DM, where visuospatial dysfunction has been prominent [15].…”

Section: Introductioncontrasting

confidence: 93%

A 5-year follow-up study of an atypical case of myotonic dystrophy

et al. 2005

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This study presents 5-year follow-up data on NG, a woman with adult onset myotonic dystrophy and progressive cognitive decline who was first described by Wilson et al. The extent of the cognitive impairment is atypical of symptom-onset in adulthood and of paternal inheritance, both of which apply to this case. Together, the present and earlier studies report the results of regular neuropsychological assessments over a 16-year period. Severe impairment in executive functioning, episodic and semantic memory were apparent early in the history, while visuospatial skills and working memory were only mildly impaired after 16 years of follow-up. There was also a progressive dyslexia, initially characterized by the regularization errors typical of surface dyslexia, but subsequently dominated by visual/phonological reading errors. This pattern of impairment is not typical of myotonic dystrophy but resembles semantic dementia. Whilst the deficits may be attributable wholly to myotonic dystrophy pathology, the co-existence of a form of semantic dementia is also possible. It is noted that the aggregation of tau protein is a neuropathological feature common to both diseases.

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Section: Introductioncontrasting

confidence: 93%

A 5-year follow-up study of an atypical case of myotonic dystrophy

et al. 2005

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“…Executive function was assessed using 2 tests. One was the Kohs Block Design Test (Kohs’ test), in which subjects are shown cards with a variety of colored designs and asked to reproduce them using a set of colored blocks, yielding an intelligence quotient [24]. This test assessed the visuospatial ability in addition to executive function.…”

Section: Methodsmentioning

confidence: 99%

The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults

Bokura

Nagai

Oguro

et al. 2010

Dement Geriatr Cogn Disord

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Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44–86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17–1.25 for Kohs’ Test; OR = 2.25, 95% CI = 1.64–3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function. Conclusion: Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population.

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“…The KBDT has been used to study visual-spatial abilities 21 and is a good predictor of the lecture ability in children.…”

Section: E T H O Dmentioning

confidence: 99%

Lead levels and cognitive abilities in Peruvian children

Vega‐Dienstmaier

Salinas-Piélago

Gutiérrez-Campos

et al. 2006

Rev. Bras. Psiquiatr.

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Lead levels and cognitive abilities in Peruvian children Níveis de chumbo e funções cognitivas em crianças peruanas A b s t r a c t Objective: To study the relationship between blood lead levels and cognitive abilities of children exposed to this metal. Method: This is a cross-sectional study that included 134 children aged 6 to 8.5 years old from 3 schools with different risks of lead exposure located in El Callao (Peru Kohs (39,6% vs. 18,6%, p = 0,01), quando comparadas com aquelas com níveis séricos menores. Um déficit de uma categoria no Teste Gráfico de Raciocínio foi associado com um aumento no nível sérico de chumbo de 16,78 ug/dl (assumindo uma relação linear) e de 1 a 5,19 ug/dl (modelo logarítmico). Para cada 10 ug/dl de aumento no nível sérico de chumbo, o Teste dos Cubos de Kohs apresentou diminuição de 6,24 unidades (12,91 para os meninos e 0,216 para as meninas) (modelo linear) e um aumento de 1 a 10 ug/dl correspondeu a uma diminuição de 16,44 pontos no Teste dos Cubos de Kohs (31,19 para os meninos e 3,98 para as meninas) (modelo logarítmico). Considerando as subescalas do Teste Gráfico de Raciocínio, os níveis séricos de chumbo correlacionaram-se negativamente com as áreas de problemas numéricos (rho = -0,445, p < 0,001), relações numéricas (rho = -0,365, p < 0,001), inferências (rho = -0,281, p = 0,002) e semelhanças (rho = -0,250, p = 0,005). Conclusões: Níveis séricos de chumbo foram associados de uma maneira não-linear com déficits das habilidades cognitivas, especialmente entre os meninos, sendo o raciocínio numérico a área mais afetada.

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The Kohs' blocks test as an important instrument to investigate the visuo-spatial impairments in myotonic dystrophy: part I. Quantitative and qualitative analysis

Cited by 17 publications

References 25 publications

A 5-year follow-up study of an atypical case of myotonic dystrophy

A 5-year follow-up study of an atypical case of myotonic dystrophy

The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults

Lead levels and cognitive abilities in Peruvian children

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