The Kinetics of the Conversion of Creatine Into Creatinine in Hydrochloric Acid Solutions

Abstract

Vol. 45 of ethylene. The more nearly normal character of the reaction at the higher temperatures is believed to be due to the fact that under these circumstances the reacting gases are not measurably adsorbed by the catalyst. The temperature coefficient is much smaller at the higher temperature and is decreasing. By taking into account the decrease of adsorption with rise in temperature as well as the normal increase in velocity of the surface reaction, these facts have been accounted for qualitatively. University, Virginia

pH-Dependent Stability of Creatine Ethyl Ester: Relevance to Oral Absorption

“…The rate of ester hydrolysis at pH 1.0 was 31-fold slower than the rate of cyclization at pH 4.0 and 37,000-fold slower than the rate at pH 7.4. Finally, no interconversion between CRT and CRN (Diamond, 2005; Edgar & Shiver, 1925; Edgar & Wakefield, 1923) was observed in any of these experiments.…”

Factors Influencing the Assay of Creatinine

“…Maximum absorbance with a neutral aqueous creatinine solution is achieved with reaction mixtures containing These findings explain the discrepancies in the literature. Since acid inhibits the hydrolysis of creatinine to creatine (Edgar and Wakefield, 1923;Edgar and Shiver, 1925) it is usually recommended that creatinine standards are made up in 0.1 M hydrochloric acid. The converse of this is true if the acidity of the creatinine solution reduces the effective concentration of the sodium hydroxide to less than 40 mmol/l, In methods where the absorbance is measured before colour development is complete (e.g., reaction rate methods, the AutoAnalyzer method of Chasson et al, (1961), or the Technicon N IIa) the reduction in reaction rate brought about by partial acidification means that a lower level of absorbance is reached in the allotted time.…”

Raman spectroscopic approach to monitor the in vitro cyclization of creatine→creatinine

“…Various researchers have attempted to explain this process by different methodologies and tried to monitor the process in vitro [6][7][8][9][10][11][12]. However the process is not very well understood till date.…”

“…In 1923, Edgar and Wakefield [8] measured the rate of cyclization of Cr to Crn. They concluded that the rate of cyclization is a function of both temperature and pH.…”