The Key Role of Corneocytes in Pityrosporoses

Pierard, Gérald; Xhauflaire-Uhoda, Emmanuelle; Piérard-Franchimont, C

doi:10.1159/000089017

Cited by 20 publications

(15 citation statements)

References 55 publications

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“…In the case of pramiconazole, the demonstrated antifungal activity does not rule out other additional effects. The putative mechanisms could include alteration in Malassezia adherence to corneocytes [38, 39], synergistic effect with the innate immune defences [40] and anti-inflammatory effects as shown for other azoles [22, 41]. …”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-<i>Malassezia</i> Agent

Pierard

Ausma²,

Henry

et al. 2007

Dermatology

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Background: Seborrheic dermatitis is considered to be a Malassezia-driven disease. Little objective information is available so far from biometrological quantitative assessments of this skin condition. Pramiconazole is a novel triazole with potent in vitro antifungal activity, especially against Malassezia spp. Objective: To study the sequential effects of pramiconazole on Malassezia, inflammation and epidermal changes. Method:This study was performed in 2 groups of subjects suffering from seborrheic dermatitis. The first group (n = 17) remained untreated and was used as control. Clinical, mycological and biometrological assessments were performed at inclusion and during the following 2 weeks. The second group of subjects (n = 10) received a single 200-mg oral dose of pramiconazole at inclusion. Clinical, mycological and biometrological evaluations were performed before and during 1 month following the single antifungal intake. For both parts of the study, several parameters were assessed including yeast density, desquamation, erythema, itching and sebum excretion. Results: In the control group, no significant changes were observed in any of the parameters during the observation period. The findings were markedly different in the pramiconazole-treated subjects. The yeast density was significantly improved on days 3, 7 and 28. Desquamation, erythema, itching, and the global clinical evaluation as assessed by the patients and investigators became significantly improved on days 7 and 28. A trend in decrease of scaliness was noted. No effect on sebum excretion was evidenced. In conclusion, a single 200-mg dose of pramiconazole exhibitsin vivo efficacy in controlling some important clinical aspects of seborrheic dermatitis. Following a reduction in the number of yeasts on day 3, a decrease in the severity of clinical signs and symptoms occurred from day 7 onwards. Sebum excretion appeared uninvolved in the clearing process of seborrheic dermatitis. Conclusion: A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in Malassezia present on lesional skin is first decreased, followed by clearing of the clinical signs.

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Section: Discussionmentioning

confidence: 99%

A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-<i>Malassezia</i> Agent

Pierard

Ausma²,

Henry

et al. 2007

Dermatology

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“…Microscopic examination of the lesions or the fungal cultures reveals characteristic oval or bottle-shaped yeast cells with budding [17]. Groups of oval or bottle-shaped cells with a diameter of 2-4µm are observed.…”

Section: Malasseziosismentioning

confidence: 99%

Dog and Cat Dermatomycoses in Regions Lining the North Atlantic Ocean

Ge¹

2017

Austin J Dermatolog

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Among the whole specters of fungi, only a few dozen species are parasitic on animals, with the vast majority being merely saprophyte organisms. Superficial dermatomycoses of the skin encompass dermatophytoses and some yeast infections. These diseases are quite common in humans, dogs and cats. Other systemic mycoses are much less common, but include cryptococcosis, sporotrichosis, histoplasmosis and North American blastomycosis. We present a review of dermatomycoses common to dogs and cats in regions lining the Atlantic Ocean.

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“…Dissemination of dermatophytes depends on direct or indirect contacts between infected and uninfected hosts. The first step in the infection process corresponds to colonisation of the cornified layers of the SC [3,4]. Fungal cells representing the contagious and infectious propagules correspond to arthroconidia and hyphal fragments adhering to, or contained within some corneocytes.…”

Section: Dermatomycoses In the Immune Compromised Patientmentioning

confidence: 99%

“…This is the crux of the problem of infections in immunocompromised patients. The adhesion of microorganisms to the stratum corneum (SC) [3,4], and its barrier system represent additive components of the skin protection. …”

Section: Introductionmentioning

confidence: 99%

Dermatophyte Growth in Glabrous Skin Dermatophytoses of Immuno Compromised Hosts

Ge¹,

C²

2015

J Med Diagn Meth

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Infections remain the most common immediate causes of morbidity in immune compromised hosts. The abated host defences are responsible for an increased susceptibility to various uncommon and opportunistic pathogens, and to a lowered host inflammatory response. Skin lesions develop in up to a third of infections in these patients, and they possibly represent the initial step of a systemic illness. Superficial mycoses are occasionally present under unusual atypical presentations. The resulting clinical infections are at times difficult to diagnose. Some of them are recalcitrant to common conventional therapies. The broad scope of cutaneous manifestations of infections in compromised patients are classified based on four presumed underlying physio-pathologic mechanisms, and on the vast array of potential pathogens so far identified. For mild superficial infections, prompt adequate therapy decreases morbidity and lessens the risk of complications. For more severe involvement, early detection of opportunistic fungal infections helps increasing both the cure and survival rates.

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The Key Role of Corneocytes in Pityrosporoses

Cited by 20 publications

References 55 publications

A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-<i>Malassezia</i> Agent

A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral Anti-<i>Malassezia</i> Agent

Dog and Cat Dermatomycoses in Regions Lining the North Atlantic Ocean

Dermatophyte Growth in Glabrous Skin Dermatophytoses of Immuno Compromised Hosts

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