The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

Côrte-Real, Leonor; Robalo, M. Paula; Marques, Fernanda; Nogueira, Guilherme; Avecilla, Fernando; Silva, Tiago J. L.; Santos, Filipa C.; Tomaz, Ana Isabel; Garcia, M. Helena; Valente, Andreia

doi:10.1016/j.jinorgbio.2015.06.015

Cited by 37 publications

(35 citation statements)

References 47 publications

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“…As a typical example, we note the use of polymeric "ruthenium-cyclopentadienyl" conjugates bearing an organometallic fragment and polylactide chains as potential anti-cancer agents with proven cytotoxic activity 133,134 and adequate aqueous stability. 134 In another interesting example, a poly(L-glutamic acid)-gra-methoxy poly(ethylene glycol) (PGA-g-mPEG) has been proposed as a has been for inclusion of cisplatin. 135,136 The resulting complex showed prolonged blood circulation time and excellent tumor accumulation.…”

Section: Metal-containing Synthetic Polymersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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Section: Metal-containing Synthetic Polymersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…Moreover, it has been shown that the metal-carbonyl complexes, in which the CO does not dissociate easily in solution, can be pharmacologically active as anticancer agents, indicating that stable metalcarbonyl complexes can be attractive candidates for drug development. 41,42 Finally, it is worth mentioning that for the evaluation of the complexes on tumor cells the complexes are dissolved in DMSO. Thus, in this case the complex 2 can have its chlorido ligand trans to the phosphorus atoms, dissociated, due to the strong trans effect of the phosphorus atoms, as observed previously for the cis-[RuCl 2 (dppb)(bipy)].…”

Section: Antitumoral Activitymentioning

confidence: 99%

Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor

Barolli¹,

Corrêa²,

Miranda³

et al. 2017

J. Braz. Chem. Soc.

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This paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX (dpqQX = dipyrido[3,2-a:2',3'-c] quinoxaline [2,3-b] quinoxaline). The complexes identified as trans-[RuCl(dppb = 1,4-bis(diphenylphosphine)butane and PPh 3 = triphenylphosphine) were characterized by 31 P{ 1 H} nuclear magnetic resonance (NMR) and infrared spectroscopies, cyclic voltammetry, molar conductance measurements, elemental analysis, mass spectrometry and X-ray diffraction analysis for complex ct-[RuCl 2 (PPh 3 ) 2 (dpqQX)]. Their in vitro cytotoxic activities against MDA-MB-213 and MCF-7 breast cancer cells were evaluated and compared with normal L-929 cells. Low drug concentration at which 50% of the cells are viable relative to the control (IC 50 ) values were obtained for all four complexes compared with a reference metallodrug, cisplatin. In addition, DNA affinity studies from titrations, as well as the images obtained by atomic force microscopy (AFM) involving pBR322 plasmid DNA, suggest interactions between the metal complexes and the DNA macromolecule, in which they act as intercalating agents. The intercalation of the complexes with DNA was confirmed by viscosity measurements.

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“…Furthermore, the oxidation potentials of the Ru II centres can be influenced by the different -donating and -accepting capacities of the coordinated ligands [10,33]. To investigate such possible correlations in the present systems and to provide further characterization of the complexes, we performed an electrochemical study by cyclic voltammetry.…”

Section: Electrochemical Experimentsmentioning

confidence: 99%

“…These arene ligands, besides stabilization of the Ru II centre, also provide a hydrophobic core for the complex which is an important feature for biomolecular recognition processes and transport of ruthenium through cell membranes. SO 3 ], TM34, and other related structures with (N,N) and (N,O) bidentate ligands as non-leaving groups and triphenylphosphane as the mono coordinated ligand [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

η6-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2′-bipyridine and its derivatives: Solution speciation and kinetic behaviour

Nogueira

Dömötör

Pilon

et al. 2016

Journal of Organometallic Chemistry

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pH values, the slow oxidation of the Ru II centre takes place as well leading to the partial loss of the arene moiety. The rate of these processes depends on the pH and its maximum was found at pH 8-9. Additionally the chlorido/aqua co-ligand exchange processes of the [Ru II ( 6 -(2-phenoxyethanol))(L)Cl] + species were also monitored and only ~5% of the chlorido ligand was found to be replaced by water in 0.1 M chloride ion containing aqueous solutions at pH 5.

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The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

Cited by 37 publications

References 47 publications

Recent advances in metallopolymer-based drug delivery systems

Recent advances in metallopolymer-based drug delivery systems

Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor

η6-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2′-bipyridine and its derivatives: Solution speciation and kinetic behaviour

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