The ketogenic diet and the QT interval

Sudhakaran, Sivakumar; Yazdani, Laila; Wheelan, Kevin; Rao, Praveen

doi:10.1080/08998280.2019.1664220

Cited by 6 publications

(3 citation statements)

References 18 publications

(16 reference statements)

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“…Moreover, epinephrine test is able to unmask the prolongation of the QT intervals in patients with ‘concealed LQTS’ [ 15 ]. The ECG may result normal at rest but based on the subtype, ECG abnormalities can be triggered by physical stress, emotional stress, dietary changes, certain drugs, or during sleep or at rest [ 16 , 17 ], and it has also been associated with metabolic syndromes and eating disorders [ 13 ]. LQTS primarily affects young people and is one of the main causes of SCD in this population [ 18 ].…”

Section: Brugada Syndrome and Long Qt Syndromementioning

confidence: 99%

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Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

et al. 2021

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A healthy regime is fundamental for the prevention of cardiovascular diseases (CVD). In inherited channelopathies, such as Brugada syndrome (BrS) and Long QT syndrome (LQTS), unfortunately, sudden cardiac death could be the first sign for patients affected by these syndromes. Several known factors are used to stratify the risk of developing cardiac arrhythmias, although none are determinative. The risk factors can be affected by adjusting lifestyle habits, such as a particular diet, impacting the risk of arrhythmogenic events and mortality. To date, the importance of understanding the relationship between diet and inherited channelopathies has been underrated. Therefore, we describe herein the effects of dietary factors on the development of arrhythmia in patients affected by BrS and LQTS. Modifying the diet might not be enough to fully prevent arrhythmias, but it can help lower the risk.

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Section: Brugada Syndrome and Long Qt Syndromementioning

confidence: 99%

“…Selenium, ketone bodies, and alcohol levels were all within normal limits. One month later, she stopped the ketogenic diet, and the ICD showed no further arrhythmic episodes [ 17 ].…”

Section: Sudden Cardiac Death and Qt Prolongation Triggered By Ketogenic Dietmentioning

confidence: 99%

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

et al. 2021

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“…Later on, total cholesterol and triglyceride levels were found slightly elevated with a significant increase in low-density lipoprotein/high-density lipoprotein ratio than before [ 144 ]. Another study found sudden cardiac death of a patient on KD suffering from congenital long QT syndrome [ 145 ]. Few AEDs and magnesium deficiency also impair myocardial functioning by elongating QT interval.…”

Section: Safety Aspects Of Kd In Epilepsymentioning

confidence: 99%

Insights into the Cellular Interactions and Molecular Mechanisms of Ketogenic Diet for Comprehensive Management of Epilepsy

Kumar

Kumari

Singh

2022

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A high-fat diet with appropriate protein and low carbohydrate content, widely known as the ketogenic diet (KD), is considered as an effective non-pharmacotherapeutic treatment option for certain types of epilepsies. Several preclinical and clinical studies have been carried out to elucidate its mechanism of antiepileptic action. Ketone bodies produced after KD's breakdown interacts with cellular excito-inhibitory processes and inhibits abnormal neuronal firing. The generated ketone bodies decrease glutamate release by inhibiting the Vesicular glutamate transporter 1 and alters the transmembrane potential by hyperpolarization. Apart from their effect on the well-known pathogenic mechanisms of epilepsy, some recent studies have shown the interaction of KD metabolites with novel neuronal targets, particularly adenosine receptors, adenosine triphosphate sensitive potassium channel, mammalian target of rapamycin, histone deacetylase, hydroxycarboxylic acid receptors, and the NLR family pyrin domain containing 3 inflammasome to suppress seizures. The role of KD in augmenting gut microbiota as a potential mechanism in epileptic seizures suppression has been established. Furthermore, some recent findings also support the beneficial effect of KD against epilepsy-associated comorbidities. Despite several advantages of the KD in epilepsy management, its use is also associated with a wide range of side effects. Hypoglycemia, excessive ketosis, acidosis, renal stones, cardiomyopathies, and other metabolic disturbances are the primary adverse effects observed with the use of KD. However, in some recent studies, modified KD has been tested with lesser side effects and better tolerability. The present review discusses the molecular mechanism of KD and its role in managing epilepsy and its associated comorbidities.

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