The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes

Zisman, Devy; Gladman, Dafna D.; Stoll, Matthew L.; Strand, Vibeke; Lavi, Idit; Hsu, Joyce; Mellins, Elizabeth; Investigators, Carra Legacy Registry

doi:10.3899/jrheum.160717

Cited by 56 publications

(51 citation statements)

References 41 publications

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“…Hip arthritis is not infrequent. Additionally, sacroiliitis can be seen [12]. Older children with jPsA tend to have more enthesitis (diagnosed by specific tenderness and occasional swelling) and axial disease.…”

Section: Joint Diseasementioning

confidence: 99%

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Overview of Juvenile Idiopathic Arthritis

Saad¹,

Onel²

2020

TOORTHJ

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Joint pain is a common symptom in children and adolescents. While there are many causes of joint pain in children, most of these are acute or not related to underlying joint inflammation. Chronic arthritis, however, can be one of the reasons behind the joint pain. The most common causes of chronic arthritis in children are categorized under juvenile idiopathic arthritis (JIA). The purpose of this review is to highlight the most important clinical features, work-up, and medical management of the different subtypes of JIA.

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Section: Joint Diseasementioning

confidence: 99%

“…Beyond arthritis and uveitis, psoriatic arthritis can also present with psoriasis, as its name suggests. Psoriasis occurs in 34 to 68% of patients with jPsA [12]. Skin findings lag behind arthritis in up to half of children with jPsA arthritis, sometimes by a decade or more [40].…”

Section: Extraarticular Manifestationsmentioning

confidence: 99%

Overview of Juvenile Idiopathic Arthritis

Saad¹,

Onel²

2020

TOORTHJ

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“…Lebensjahr erkrankten Patienten bei 18,8 % und der nach dem 4. Lebensjahr erkrankten Patienten bei 8,8 % (p = 0,015) [16].…”

Section: Nicht-infektiöse Uveitiden Assoziiert Mit Eine Extraokulärenunclassified

Rheumatologische Differenzialdiagnostik bei Uveitis im Kindesalter

Foeldvari

2019

Akt Rheumatol

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ZusammenfassungUngefähr 10% der Uveitiden beginnen im Kindesalter, mit einer Inzidenz von 6,9 auf 100 000 unter 14 Jahren und 26,6 auf 100 000 von 15 bis 24 Jahren. Sie werden unterteilt in infektiöse und nichtinfektiöse Uveitiden. Die Klassifikation der SUN-Gruppe erfolgt je nach Lokalisation des Auftretens und abhängend vom zeitlichen Verlauf. Die häufigste nicht-infektiöse Ursache bei Kindern ist die Juvenile idiopathische Arthritis, gefolgt von Morbus Behcet und Sarkoidose. Auch autoinflammatorischen Erkrankungen können mit einer Uveitis assoziiert sein. Die anteriore Uveitis tritt vorwiegend bei der Juvenilen idiopathischern Arthritis, der lokalisierten Sklerodermie und dem Kawasaki-Syndrom auf. Bei der intermediären Uveitis gibt es vor allem eine Assoziation mit Sarkoidose, Blau Syndrom, Tinu Syndrom und Multipler Sklerose. Eine posteriore Beteiligung ist für Morbus Behcet typisch, kann aber auch beim Cryopirin-assoziiertem Fiebersyndrom oder Cogan-Syndrom auftreten. Eine frühzeitige Diagnosestellung ist wichtig, um rechtzeitg eine effektive Therapie einleiten zu können und das Sehvermögen nicht zu gefährden.

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“…The first version of this observational registry was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) American Recovery and Reinvestment Act Grand Opportunities grant RC2AR058934 in 2009 and enrolled 9,500 patients over 3 years at 62 CARRA sites. The Legacy Registry demonstrated the feasibility of capturing data from a large cohort of children with a range of rheumatic diseases, and the resulting data have been used to describe phenotypes, treatment patterns, and disease outcomes for a number of pediatric rheumatic diseases (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Carra and The Carra Registrymentioning

confidence: 99%

The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans

Ringold

Nigrović

Feldman

et al. 2018

Arthritis & Rheumatology

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The pediatric rheumatic diseases are a heterogeneous group of rare diseases, posing a number of challenges for the use of traditional clinical and translational research methods. Innovative comparative effectiveness approaches are needed to efficiently study treatment strategies and disease outcomes. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed the consensus treatment plan (CTP) approach as a comparative effectiveness tool for research in pediatric rheumatology. CTPs are treatment strategies, developed by consensus methods among CARRA members, intended to reduce variation in treatment approaches, standardize outcome measurements, and allow for comparison of the effectiveness of different approaches with the goal of improving disease outcomes. To date, CTPs have been published for 8 different diseases and disease manifestations. The approach has been successfully piloted for juvenile localized scleroderma, systemic juvenile idiopathic arthritis (JIA), polyarticular JIA, dermatomyositis, and lupus nephritis. Large-scale studies are underway for systemic JIA and polyarticular JIA, with the CARRA patient registry serving as the data collection platform. These studies have been designed with stakeholder involvement, including active input from CARRA providers, patients, and parents, with the goal of increasing feasibility and ensuring the relevance of the outcomes. These studies include ancillary biologic specimen collection intended to support additional translational and mechanistic studies. Data from these ongoing CTP studies will provide more information on the ability of this approach to identify effective treatment strategies and improve outcomes in the pediatric rheumatic diseases.

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The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes

Cited by 56 publications

References 41 publications

Overview of Juvenile Idiopathic Arthritis

Overview of Juvenile Idiopathic Arthritis

Rheumatologische Differenzialdiagnostik bei Uveitis im Kindesalter

The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans

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