The journey of hyaluronan research in the Journal of Biological Chemistry

Hascall, Vincent C.

doi:10.1074/jbc.tm118.005836

Cited by 26 publications

(15 citation statements)

References 60 publications

(50 reference statements)

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“…The most widely acknowledged role of the IαI family members is the transesterification of HCs from IαI to hyaluronan (HA) in the presence of tumor necrosis factor–stimulated gene-6 (TSG-6), a process that results in the covalent modification of HA with HCs (HA·HC) 70–72 and recently reviewed in detail. 73 This process is conserved across mammals, birds, and reptiles.…”

Section: Overview Of Iαimentioning

confidence: 99%

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology

Lord

Melrose

Day

et al. 2020

J Histochem Cytochem.

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Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution. IαI is a complex containing the proteoglycan bikunin to which heavy chain proteins are covalently attached to the chondroitin sulfate chain. Besides its matrix protective activity through protease inhibitory action, IαI family members interact with extracellular matrix molecules and most notably hyaluronan, inhibit complement, and provide cell regulatory functions. Recent evidence for the diverse roles of the IαI family in both biology and pathology is reviewed and gives insight into their pivotal roles in tissue homeostasis. In addition, the clinical uses of these molecules are explored, such as in the treatment of inflammatory conditions including sepsis and Kawasaki disease, which has recently been associated with severe acute respiratory syndrome coronavirus 2 infection in children:

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Section: Overview Of Iαimentioning

confidence: 99%

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology

Lord

Melrose

Day

et al. 2020

J Histochem Cytochem.

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“…Among these are heparin, heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), and keratan sulfate (KS), which are covalently bound to core proteins, forming proteoglycans (PGs) ( Kjellen and Lindahl, 1991 ; Iozzo, 1998 ; Lindahl et al, 2015 ). Hyaluronan (HA) is a free polysaccharide ( Lindahl and Rodén, 1972 ; Hascall, 2019 ). PGs are distributed in the extracellular matrix and on cell surfaces, and are crucially involved in a wide range of biological processes such as cell adhesion, the regulation of cellular signaling, and assembly of the extracellular matrix ( Esko and Selleck, 2002 ; Häcker et al, 2005 ; Bülow and Hobert, 2006 ; Bishop et al, 2007 ; Sarrazin et al, 2011 ; Thelin et al, 2013 ; Xu and Esko, 2014 ; Mizumoto et al, 2015 ; Neill et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles

Huang

Mizumoto²,

Fujita³

2021

Front. Cell Dev. Biol.

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Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans. More than 50 gene products are involved in the biosynthesis of GAGs. We recently developed a comprehensive glycosylation mapping tool, GlycoMaple, for visualization and estimation of glycan structures based on gene expression profiles. Using this tool, the expression levels of GAG biosynthetic genes were analyzed in various human tissues as well as tumor tissues. In brain and pancreatic tumors, the pathways for biosynthesis of chondroitin and dermatan sulfate were predicted to be upregulated. In breast cancerous tissues, the pathways for biosynthesis of chondroitin and dermatan sulfate were predicted to be up- and down-regulated, respectively, which are consistent with biochemical findings published in the literature. In addition, the expression levels of the chondroitin sulfate-proteoglycan versican and the dermatan sulfate-proteoglycan decorin were up- and down-regulated, respectively. These findings may provide new insight into GAG profiles in various human diseases including cancerous tumors as well as neurodegenerative disease using GlycoMaple analysis.

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“…Hyaluronic acid (HA) is a linear glycosaminoglycan (GAG) molecule composed of disaccharide units of GlcNAc and D-glucuronic acid linked together with β-1,4 and β-1,3 glycosidic bonds. The sequence can be repeated over 20,000 times [26]. Hyaluronic acid was first discovered in the vitreous humor in 1934 by Karl Meyer and John Palmer.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…Hyaluronic acid was first discovered in the vitreous humor in 1934 by Karl Meyer and John Palmer. They proposed the name "hyaluronic acid" lending from the Greek hyaloid (vitreous) and uronic acid, one of the two repeating monosaccharide units [26].…”

Section: Hyaluronic Acidmentioning

confidence: 99%

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Contribution of Topical Agents to Wound Healing

Voljč¹,

Semenič²

2022

Recent Advances in Wound Healing

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The process of wound healing is often accompanied by bacterial infection or critical colonization, which leads to an extension of the inflammatory response phase and delayed epithelization. In the review of scientific articles, we found the description and mode of action of topical antiseptic agents, including silver and sodium hypochlorite solution, to control the spread of microorganisms. The value of hyaluronic acid for wound healing is described. Furthermore, a novel treatment option with microspheres is mentioned. Attachment of cells to microspheres establishes a local cytokine response that acts anti-inflammatory, cell attachment results also in morphological and functional cell changes that reactivate healing.

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The journey of hyaluronan research in the Journal of Biological Chemistry

Cited by 26 publications

References 60 publications

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology

The Inter-α-Trypsin Inhibitor Family: Versatile Molecules in Biology and Pathology

Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles

Contribution of Topical Agents to Wound Healing

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