The Journey of Elastography: Background, Current Status, and Future Possibilities in Breast Cancer Diagnosis

Elastography-based imaging techniques have received substantial attention in recent years for non-invasive assessment of tissue mechanical properties. These techniques take advantage of changed soft tissue elasticity in various pathologies to yield qualitative and quantitative information that can be used for diagnostic purposes. Measurements are acquired in specialized imaging modes that can detect tissue stiffness in response to an applied mechanical force (compression or shear wave). Ultrasound-based methods are of particular interest due to its many inherent advantages, such as wide availability including at the bedside and relatively low cost. Several ultrasound elastography techniques using different excitation methods have been developed. In general, these can be classified into strain imaging methods that use internal or external compression stimuli, and shear wave imaging that use ultrasound-generated traveling shear wave stimuli. While ultrasound elastography has shown promising results for non-invasive assessment of liver fibrosis, new applications in breast, thyroid, prostate, kidney and lymph node imaging are emerging.Here, we review the basic principles, foundation physics, and limitations of ultrasound elastography and summarize its current clinical use and ongoing developments in various clinical applications.

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“…Early diagnosis of breast cancer through screening tests allows for the possibility of a complete cure 13.…”

Section: Clinical Applications Of Ultrasound Elastographymentioning

confidence: 99%

Ultrasound Elastography: Review of Techniques and Clinical Applications

et al. 2017

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“…Since development in the 1990s, ultrasound elastography (Ophir et al, 1991) and magnetic resonance elastography (Muthupillai et al, 1995) have become clinically available tools for detecting pathologies such as thyroid malignancies (Azizi et al, 2015), breast cancer (Aglyamov et al, 2012; Faruk et al, 2015), and hepatic fibrosis (Venkatesh et al, 2013). However, these techniques require a relatively large displacement to produce a detectable signal, have limited spatial resolution, and require contact with the tissue, all of which restrict their use on small and thin samples such as the cornea.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

Han

Singh

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

103

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The biomechanical properties of the cornea play a critical role in forming vision. Diseases such as keratoconus can structurally degenerate the cornea causing a pathological loss in visual acuity. UV-A/riboflavin corneal collagen crosslinking (CXL) is a clinically available treatment to stiffen the cornea and restore its healthy shape and function. However, current CXL techniques do not account for pre-existing biomechanical properties of the cornea nor the effects of the CXL treatment itself. In addition to the inherent corneal structure, the intraocular pressure (IOP) can also dramatically affect the measured biomechanical properties of the cornea. In this work, we present the details and development of a modified Rayleigh-Lamb frequency equation model for quantifying corneal biomechanical properties. After comparison with finite element modeling, the model was utilized to quantify the viscoelasticity of in situ porcine corneas in the whole eye-globe configuration before and after CXL based on noncontact optical coherence elastography measurements. Moreover, the viscoelasticity of the untreated and CXL-treated eyes was quantified at various IOPs. The results showed that the stiffness of the cornea increased after CXL and that corneal stiffness is close to linear as a function of IOP. These results show that the modified Rayleigh-Lamb wave model can provide an accurate assessment of corneal viscoelasticity, which could be used for customized CXL therapies.

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“…This is to be mentioned that Bangladesh has a unique National Cancer Control Strategy and Plan of Action 2009-2015 formulated in collaboration with WHO with an objective to improve the cancer situation by raising the preventive measures including reduced tobacco smoking, change of dietary habit and reduced food adulteration, ensuring reproductive hygiene, increased physical activity, and reduced occupational hazard in order to reduce the incidence of cancer. Some other major cancer preventive programs have also been undertaken by the governmental and non-governmental organizations (79,90,(92)(93)(94).…”

Section: Cancer Diagnosis and Treatment In Bangladeshmentioning

confidence: 99%

State of cancer in Bangladesh: An introductory review on microbiological perspective

2016

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Present review emphasized on the current state of cancer in Bangladesh and attempted to focus on the association of microorganisms in the development of cancer. People of Bangladesh have long been suffering from a range of diseases principally due to lack of required resources for disease diagnosis and subsequent treatment facilities. As a developing country with the lack of public awareness on hygiene, emerging infectious diseases conquered the countries. In this circumstance, the onset of cancer is appears as the incurable complications. In the country, cancer is an escalating fatal issue causing a mass scale of mortality each year. Moreover, while etiologic microorganisms are frequently detected during the common disease diagnosis, the pathogenic association with cancer formation remains obscure to the physicians in Bangladesh. While mortality and survival rate of cancer largely depends on the diagnosis and subsequent mitigation, hence it is essential to resolve the possible risk of cancer development in accordance to microbial attack.Stamford Journal of Microbiology, Vol.5(1) 2015: 30-35

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The Journey of Elastography: Background, Current Status, and Future Possibilities in Breast Cancer Diagnosis

Cited by 74 publications

References 83 publications

Ultrasound Elastography: Review of Techniques and Clinical Applications

Ultrasound Elastography: Review of Techniques and Clinical Applications

Optical coherence elastography assessment of corneal viscoelasticity with a modified Rayleigh-Lamb wave model

State of cancer in Bangladesh: An introductory review on microbiological perspective

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