Ultrasound Elastography: Review of Techniques and Clinical Applications

Sigrist, R; Liau, Joy; Kaffas, Ahmed El; Chammas, Maria Cristina; Willmann, Jüergen K.

doi:10.7150/thno.18650

Cited by 1,303 publications

(1,331 citation statements)

References 147 publications

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“…The technique has been described in detail in the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) and World Federation for Ultrasound in Medicine and Biology (WFUMB) guidelines [1,2,4,6,45] and also by others [46]. TE has been used for liver stiffness measurement (LSM) both in children and adults [1,2,47,48].…”

Section: Transient Elastography (Te)mentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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Section: Transient Elastography (Te)mentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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“…On the contrary, the smaller the elasticity coefficient is, the larger the morphological change will be. This generalization suggests that deformation of normal soft tissues is much more significant than that of hard tumor tissues [8]. Ultrasonic elastography aims to generate different morphological changes based on differences between the tumor or lesion area and the surrounding normal tissues in terms of the elasticity coefficient.…”

Section: Discussionmentioning

confidence: 99%

Clinical value of ultrasonic elastography in diagnosing thyroid carcinoma

Lin¹

2018

biomedicalresearch

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Objective: This study aims to explore the clinical value of ultrasonic elastography in diagnosing thyroid carcinoma. Methods: Eighty thyroid carcinoma patients (100 nodules) admitted to a hospital were enrolled in this research. Routine ultrasonic testing and elastography were administered to all patients. The color and condition (benign or malignant) of the nodules were determined. The results were compared with pathogenic diagnosis of the operation. The specificity, sensitivity, and accuracy of the two test methods were computed and statistically compared. Results: Pathological diagnosis of the operation suggested that among the 100 nodules, 70 were benign and 30 were malignant. The specificity, sensitivity, and accuracy of the routine ultrasonic check diagnosis were 50.00%, 53.33%, and 51.00%, respectively, whereas those of the ultrasonic elastography were 92.86%, 96.67% and 94.00%, respectively. The former was significantly (P<0.05) higher than the latter in all parameters. Conclusion: Ultrasonic elastography showed a significantly higher critical value in diagnosing thyroid carcinoma and could accurately identify nodules as either benign or malignant. Hence, ultrasonic elastography is worth further critical promotion and application.

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“…Among them, shear wave elastography (SWE) recently has become available on multiple systems and is attractive due to its 2D imaging capability and quantitative nature. Because of the unique tissue mechanical information provided, numerous clinical studies have demonstrated the clinical utility of ultrasound elastography, such as in liver, breast, prostate, kidney, pancreas, and musculoskeletal (MSK) applications 6, 7, 8, 9, 10, 11. For example, 2D SWE was shown to have high sensitivity in the assessment of liver fibrosis 12.…”

Section: Introductionmentioning

confidence: 99%

Clinical acceptance testing and scanner comparison of ultrasound shear wave elastography

Long

Tradup

Song

et al. 2018

J Applied Clin Med Phys

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Because of the rapidly growing use of ultrasound shear wave elastography (SWE) in clinical practices, there is a significant need for development of clinical physics performance assessment methods for this technology. This study aims to report two clinical medical physicists’ tasks: (a) acceptance testing (AT) of SWE function on ten commercial ultrasound systems for clinical liver application and (b) comparison of SWE measurements of targets across vendors for clinical musculoskeletal application. For AT, ten GE LOGIQ E9 XDclear 2.0 scanners with ten C1‐6‐D and ten 9L‐D transducers were studied using two commercial homogenous phantoms. Five measurements were acquired at two depths for each scanner/transducer pair by two operators. Additional tests were performed to access effects of different coupling media, phantom locations and operators. System deviations were less than 5% of group mean or three times standard deviation; therefore, all systems passed AT. A test protocol was provided based on results that no statistically significant difference was observed between using ultrasound gel and salt water for coupling, among different phantom locations, and that interoperator and intraoperator coefficient of variation was less than 3%. For SWE target measurements, two systems were compared — a Supersonic Aixplorer scanner with a SL10‐2 and a SL15‐4 transducer, and an abovementioned GE scanner with 9L‐D transducer. Two stepped cylinders with diameters of 4.05–10.40 mm were measured both longitudinally and transaxially. Target shear wave speed quantification was performed using an in‐house MATLAB program. Using the target shear wave speed deduced from phantom specs as a reference, SL15‐4 performed the best at the measured depth. However, it was challenging to reliably measure a 4.05 mm target for either system. The reported test methods and results could provide important information when dealing with SWE‐related tasks in the clinical environment.

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Ultrasound Elastography: Review of Techniques and Clinical Applications

Cited by 1,303 publications

References 147 publications

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Clinical value of ultrasonic elastography in diagnosing thyroid carcinoma

Clinical acceptance testing and scanner comparison of ultrasound shear wave elastography

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