“…The Janus activated kinase (JAK) and Signal Transducer and Activator of Transcription 3 (STAT3) signalling pathway is responsive to a large number of cytokines, growth factors and hormones [6,7,18], and is known to play a vital role in cardioprotection related to ischemia-reperfusion (I/R) injury [2,13,16,24,26,28,29,39,46]. This pathway is activated by a diversity of receptors, including receptor tyrosine kinases [38,45,51] and Gprotein-coupled receptors [11,33].…”