The ISSCR Guidelines for Human Embryonic Stem Cell Research

Daley, George Q.; Richter, Lars; Auerbach, Jonathan M.; Benvenisty, Nissim; Charo, R. Alta; Chen, Grace; Deng, Hongkui; Goldstein, Lawrence S.B.; Hudson, Kathy; Hyun, Insoo; Junn, Sung Chull; Love, Jane M.; Lee, Eng Hin; McLaren, Anne; Mummery, Christine L.; Nakatsuji, Norio; Racowsky, Catherine; Rooke, Heather M.; Rossant, Janet; Schöler, Hans R.; Solbakk, Jan Helge; Taylor, Patrick; Trounson, Alan; Weissman, Irving L.; Wilmut, Ian; Yu, John; Zoloth, Laurie

doi:10.1126/science.1139337

Cited by 98 publications

(56 citation statements)

References 5 publications

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“…Our data reveal a hidden unity in vertebrate mesoderm induction and suggest that the streak is not a defining feature of amniote mesoderm formation. Because the streak is an important criterion in ethical debates surrounding the use and in vitro culture of human stem cells (Daley et al, 2007), the embryological definition and evolutionary significance of the streak deserve re-evaluation.…”

Section: Discussionmentioning

confidence: 99%

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

Alev¹,

Wu²,

Nakaya³

et al. 2013

Development

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Mesoderm is formed during gastrulation. This process takes place at the blastopore in lower vertebrates and in the primitive streak (streak) in amniotes. The evolutionary relationship between the blastopore and the streak is unresolved, and the morphogenetic and molecular changes leading to this shift in mesoderm formation during early amniote evolution are not well understood. Using the chick model, we present evidence that the streak is dispensable for mesoderm formation in amniotes. An anamniote-like circumblastoporal mode of gastrulation can be induced in chick and three other amniote species. The induction requires cooperative activation of the FGF and Wnt pathways, and the induced mesoderm field retains anamniote-like dorsoventral patterning. We propose that the amniote streak is homologous to the blastopore in lower vertebrates and evolved from the latter in two distinct steps: an initial pan-amniote posterior restriction of mesoderm-inducing signals; and a subsequent lineage-specific morphogenetic modification of the pre-ingression epiblast.

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Section: Discussionmentioning

confidence: 99%

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

Alev¹,

Wu²,

Nakaya³

et al. 2013

Development

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show abstract

“…While transplantation of stem cells for the therapeutic management of disease and degenerative conditions may one day be realized, this approach has to be considered in the context of a number of potential limitations, including immunorejection (53), teratogenesis and tumorigenesis (54), and ethical debates (55). Recent advances in generating induced pluripotent stem cells (iPS) may alleviate some of these concerns (56), but considerable work is still needed to determine if a transplantation effect, such as that shown here, is a viable option for use in humans.…”

Section: Discussionmentioning

confidence: 99%

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells

Acharya

Christie

Lan

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

114

151

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Cranial irradiation remains a frontline treatment for the control of tumor growth, and individuals surviving such treatments often manifest various degrees of cognitive dysfunction. Radiation-induced depletion of stem/precursor cell pools in the brain, particularly those residing in the neurogenic region of the hippocampus, is believed, in part, to be responsible for these often-unavoidable cognitive deficits. To explore the possibility of ameliorating radiation-induced cognitive impairment, athymic nude rats subjected to head only irradiation (10 Gy) were transplanted 2 days afterward with human embryonic stem cells (hESC) into the hippocampal formation and analyzed for stem cell survival, differentiation, and cognitive function. Animals receiving hESC transplantation exhibited superior performance on a hippocampal-dependent cognitive task 4 months postirradiation, compared to their irradiated surgical counterparts that did not receive hESCs. Significant stem cell survival was found at 1 and 4 months postirradiation, and transplanted cells showed robust migration to the subgranular zone throughout the dentate gyrus, exhibiting signs of neuron morphology within this neurogenic niche. These results demonstrate the capability to ameliorate radiation-induced normal tissue injury using hESCs, and suggest that such strategies may provide useful interventions for reducing the adverse effects of irradiation on cognition.cognition ͉ stem cells ͉ radiotherapy

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“…Indeed, although ESCs are pluripotent cells which maintain high plasticity and extensive selfrenewal capacity, possible host immune rejection after allotransplantation and the formation of tumors when injected undifferentiated or partially differentiated in vivo, raise safety concerns [4648] . Furthermore, their clinical use is limited by ethical issues due to the need to isolate them from the inner cell mass of a blastocyst [49] .…”

Section: Amniotic Fluid-derived Cellsmentioning

confidence: 99%

Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential

Pipino

Pandolfi

2015

WJSC

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The ISSCR Guidelines for Human Embryonic Stem Cell Research

Cited by 98 publications

References 5 publications

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells

Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential

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