Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential

Pipino, Caterina; Pandolfi, Assunta

doi:10.4252/wjsc.v7.i4.681

Cited by 20 publications

(14 citation statements)

References 98 publications

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“…Currently, stem cells are being investigated for the repair and regeneration of cartilage, bone, ligament, tendon, and muscle tissue [123]. These cells have the capability to (1) replicate; (2) release bioactive substances such as growth factors, cytokines, and chemokines for the growth and migration of cells, (3) immuno-modulate the tissue environment, allowing the tissue healing; (4) differentiate into the cell phenotype of the tissue of interest [124]. A significant challenge has been to develop suitable carriers to deliver these cells to the injury site to take advantage of their healing potential.…”

Section: The Principles Of Regenerative Engineeringmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

376

240

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Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

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Section: The Principles Of Regenerative Engineeringmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

376

240

View full text Add to dashboard Cite

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“…It is well known that mesenchymal stem cells (MSCs) can be isolated from various sources such as bone marrow, umbilical cord blood, placenta, adipose tissue, muscle, corneal stroma synovium, and periosteum (Quirici et al, 2002;Miao et al, 2006;Yoshimura et al, 2007;Jin et al, 2013;Kureshi et al, 2014). MSCs can differentiate into various types of cell including osteoblasts, chondrocytes, adipocytes, neurons, and cardiomyocytes (Toma et al, 2002;Chuah et al, 2015;Pipino and Pandolfi, 2015;Zhuang et al, 2015) and exhibit beneficial effects such as angiogenesis and immune regulation (Castro-Manrreza and Montesinos, 2015;Kim and Cho, 2015). Potential functions of MSCs vary depending on the source and different experimental conditions, and MSCs can be used in clinical applications to treat different kinds of disease (Garcia-Olmo et al, 2009;Cho et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…MSCs can differentiate into various types of cell including osteoblasts, chondrocytes, adipocytes, neurons, and cardiomyocytes (Toma et al, 2002;Chuah et al, 2015;Pipino and Pandolfi, 2015;Zhuang et al, 2015) and exhibit beneficial effects such as angiogenesis and immune regulation (Castro-Manrreza and Montesinos, 2015;Kim and Cho, 2015). Potential functions of MSCs vary depending on the source and different experimental conditions, and MSCs can be used in clinical applications to treat different kinds of disease (Garcia-Olmo et al, 2009;Cho et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of angiogenic effects by hypoxia‐preconditioned human umbilical cord‐derived mesenchymal stem cells in a mouse model of hindlimb ischemia

Han

Kim

et al. 2015

Cell Biology International

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It has been studied that mesenchymal stem cells (MSCs) have the capability to promote angiogenesis. Furthermore, there is strong evidence that hypoxic conditions can enhance angiogenesis and immune modulation mediated by MSCs, a notion that has been applied in many fields of clinical application. In the present study, we compared the efficacy of hypoxia preconditioned human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and normoxia conditioned hUC-MSCs for the treatment of ischemic injury in hindlimbs of an immunodeficient mouse model. Expression of negative markers for MSC such as CD31, CD34, and CD45 or positive markers such as CD44, CD73, CD90, and CD105 was not significantly changed in hypoxia preconditioned hUC-MSCs compared with hUC-MSCs cultured in normoxic condition. Expression of angiogenesis-related genes such as COX-2, VEGF, Tie-2, and TGF-β1 was increased compared with hUC-MSCs cultured in normoxic conditions. In the in vivo model, CD31 expression as a marker of angiogenesis was significantly increased in the ischemic limbs at 1 month after injection with hypoxic hUC-MSCs. Angiogenesis-related genes such as Ang-1, COX-1, PIGF, and MCP-1 were significantly upregulated in the muscle of ischemic hindlimbs treated with hypoxic hUC-MSCs than normoxic hUC-MSCs. Expression of proinflammatory genes such as IL-1, and IL-20 was reduced, whereas TGF-β1, which has an anti-inflammatory effect, was strongly increased. In conclusion, hypoxic culture conditions could induce expression of angiogenesis related genes in hUC-MSCs, and hypoxia preconditioned hUC-MSCs showed enhancing effects by inducing angiogenesis and low inflammatory immune response compared with normoxic hUC-MSCs in the ischemia injured hindlimb of immunodeficient mice.

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“…These cells grow rapidly in routine culture (Li et al 2015). Based on their morphological, biochemical, and growth characteristics of adherent AF cells, these cells can be classified into three groups: (1) AF-specific AF-type cells, (2) fibroblastic F-type cells, and (3) epithelioid E-type cells (Pipino and Pandolfi 2015). Both the AF-specific AF-type cells and the epithelioid E-type cells are found in the initial passages of cultivation.…”

Section: Characteristics Of Amniotic Fluid/membranementioning

confidence: 99%

“…Both the AF-specific AF-type cells and the epithelioid E-type cells are found in the initial passages of cultivation. The AF-specific AF-type cells are likely derived from placental trophoblastic tissue and produce estrogen, chorionic gonadotropin, and progesterone, but the epithelioid E-type cells likely derived from the fetal skin (Pipino and Pandolfi 2015).…”

Section: Characteristics Of Amniotic Fluid/membranementioning

confidence: 99%

An update clinical application of amniotic fluid-derived stem cells (AFSCs) in cancer cell therapy and tissue engineering

Aziz

Fathi

Rahmati-Yamchi

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Recent studies have elucidated that cell-based therapies are promising for cancer treatments. The human amniotic fluid stem (AFS) cells are advantageous cells for such therapeutic schemes that can be innately changed to express therapeutic proteins. HAFSCs display a natural tropism to cancer cells in vivo. They can be useful in cancer cells targeting. Moreover, they are easily available from surplus diagnostic samples during pregnancy and less ethical and legal concern are associated with the collection and application than other putative cells are subjected. This review will designate representatives of amniotic fluid and stem cell derived from amniotic fluid. For this propose, we collect state of human AFS cells data applicable in cancer therapy by dividing this approach into two main classes (nonengineered and engineered based approaches). Our study shows the advantage of AFS cells over other putative cells types in terms differentiation ability to a wide range of cells by potential and effective use in preclinical studies for a variety of diseases. This study has shown the elasticity of human AFS cells and their favorable potential as a multipotent cell source for regenerative stem cell therapy and capable of giving rise to multiple lineages including such as osteoblasts and adipocyte.

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Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential

Cited by 20 publications

References 98 publications

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Enhancement of angiogenic effects by hypoxia‐preconditioned human umbilical cord‐derived mesenchymal stem cells in a mouse model of hindlimb ischemia

An update clinical application of amniotic fluid-derived stem cells (AFSCs) in cancer cell therapy and tissue engineering

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