The Isolation and Characterization of L-Homoarginine from Seeds of Lathyrus sativus^*

β-N-oxalyl-L-2,3-diaminopropionic acid, L-homoarginine, and asparagine contents in the seeds of different genotypes Lathyrus sativus L. as determined by UHPLC-MS/MS

“…Similar to asparagine, homoarginine is a natural substrate for nitric oxide which emerged as important signaling molecule in both the cardiovascular system and cerebral metabolism. Therefore, grass pea is an important plant species as a valuable natural dietary source of homoarginine (Rao et al, 1963;Yun et al, 2011). [17,36] When the β-ODAP, L-homoarginine, and asparagine contents of 173 grass pea genotypes were evaluated, a broad range was observed in each case.…”

“…Therefore, grass pea is an important plant species as a valuable natural dietary source of homoarginine (Rao et al, 1963;Yun et al, 2011). [17,36] When the β-ODAP, L-homoarginine, and asparagine contents of 173 grass pea genotypes were evaluated, a broad range was observed in each case. One of the 173 total grass pea genotypes was found to have a total content <0.2% (LS-106: 0.155%), which is within the confidence limits interval for human and animal consumption.…”

“…Homoarginine in L. sativus contributes to cardiovascular health. [16][17][18] Homoarginine, which also play an important role in physiological and biochemical processes has been proposed to modulate the toxicity of β-ODAP. [19] L. sativus seeds are also rich in L-homoarginine, which acts as a precursor for lysine in higher animals.…”

Biosynthesis of the pyrimidinyl amino acid lathyrine by Lathyrus tingitanus L.

“…Postulated relationship between orotate, lathyrine and homoarginine by Bell (1963), Rao et al (1963) andPrzybylska (1965) that the 14C label from L-[guanidino-14C]homoarginine is incorporated into lathyrine (Table 3). These observations could be interpreted in terms of two independent biosynthetic routes to lathyrine.…”

Biosynthesis and regulation of polyamines in higher plants

“…The choice of L. sativus was promoted by our earlier observation [43] that the seeds of this legume are a rich source of L-homoarginine and that neither the metabolic fate nor the physiological significance of this nitrogen-rich unusual guanido amino acid during germination and seedling growth was known at that time. It was attractive to visualize that besides serving as a rich nitrogen source, this unusual free amino acid could also contribute vital metabolites such as di-and polyamines during seed germination/plantlet development.…”