The Iron Metabolism in Children Is Normal Also at Infectious Diseases

Aliyeva, A. M; Намазова-баранова, Л. С.; Kazyukova, Т. V.; Студеникин, В. М.

doi:10.22627/2072-8107-2017-16-1-21-27

Cited by 4 publications

References 33 publications

(43 reference statements)

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Latent Iron Deficiency in Tender-Age Infants: Modern Preventive Measures

Belyaeva,

Bombardirova,

Turti

2023

Pediatr. farmakol.

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This article presents practical data, topical for pediatricians, on the child’s body provision with the essential trace element — iron; and on iron deficiency conditions development and staging in children. Clinical and laboratory criteria for the identification of such conditions are defined; data on their prevalence in tender-age infants is outlined. The results of modern studies showing the correlations between iron deficiency and delayed developmental conditions in children (including cognitive ones) are presented. Alimental factors (associated with body provision with iron) and nutritional strategies (associated with supplemental feeding timely administration, adequacy, and diversity) are described in detail. They are focused on effective and safe prevention of latent iron deficiency.

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Latent Iron Deficiency in Tender-Age Infants: Modern Preventive Measures

Belyaeva,

Bombardirova,

Turti

2023

Pediatr. farmakol.

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The informativity of the markers of iron metabolism in the differential diagnosis of anemia of inflammation in children with chronic HBV infection

Иноятова

Икрамова

Иногамова

et al. 2021

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Objective: To assess diagnostic importance of iron metabolism markers in the progression of anemia of inflammation (AI) in children with chronic HBV infection.Materials and methods: Among 148 examined children with chronic HBV infection 140 had AI, 60.7% of them with refractory (RA) and 39.3% with non-refractory (nRA) progression variant. Complete blood count was performed using hematologic automatic analyzer. Virologic verification of HBV was done by ELISA and PCR. ELISA was used to determine 25-hepcidin, serum iron, ferritin, trasferrin, sTfR, IL-1, IL-6. The index sTfR/log10Ft was calculated.Results: Performing the examination of children with chronic HBV infection we determined high prevalence of AI, equal to 94.6%, which was characterized by normocyte normochromic progression, thrombocytopenia, thrombocrit decrease in case of RA, and microcyte hypochromic progression with erythrocyte anisocytosis in case of nRA. Despite the high inflammatory index induced by HBV viral replication, children with RA had characteristic decrease in 25-hepcidin and transferrin parameters with background high values of ferritin, while nRA was characterized by rise of 25-hepcidin and transferrin spectrum with low values of serum iron and ferritin.Conclusions. In the genesis of AI in chronic HBV cases two pathogenic variants were determined: true iron deficiency with ferromarkers in the type of IDA characteristic for nRA and redistribution iron deficiency compliant to hemosiderosis characteristic for RA. Priority in the differential diagnosis of AI variants is given to the comparison of sTfR/log10Ft index parameters (RA<1.0; nRA>2.0) with reference level of 25-hepcidin<28,68ng/ml in case of RA, and >56,37ng/ml in case of nRA.

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Etiological structure of anemia in HIV-infected children

et al. 2019

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В большинстве случаев у пациентов детского возраста ВИЧ-инфекция сопровождается развитием анемии со снижением уровня гемоглобина. Изучали структуру анемии у 114 детей с ВИЧ-инфекцией в возрасте от 1 года жизни до 18 лет. В зависимости от клинической стадии ВИЧ-инфекции пациенты были разделены на 3 группы: 1-я группа -20 детей со второй клинической стадией ВИЧ-инфекции; 2-я группа -74 ребенка с третьей клинической стадией; 3-я группа -20 детей с четвертой клинической стадией. Определяли сывороточное железо и ферритин. У большинства пациентов (95,2%) исследуемых групп была выявлена железодефицитная анемия (ЖДА), в 4,8% случаев анемия хронических заболеваний (АХЗ). Важность дифференцировки выявленной анемии определяет терапевтическую тактику и необходимость назначения железосодержащих препаратов. Ключевые слова: ВИЧ-инфекция, железодефицитная анемия, анемия хронических заболеваний, железо, ферритин In most cases, HIV infection in children is accompanied by the development of anemia with a decrease in hemoglobin levels. We studied the structure of anemia in 114 children with HIV infection aged from 1 year to 18 years. Depending on the clinical stage of HIV infection, the patients were divided into 3 groups: 1st group -20 children with the second clinical stage of HIV infection; 2nd group -74 children with the third clinical stage; 3rd group -20 children with a fourth clinical stage. Serum iron and ferritin were determined. In the majority of patients (95.2%) of the studied groups iron deficiency anemia (IDA) was detected, in 4.8% of cases anemia of chronic diseases (ACD) was detected. The importance of differentiation of the identified anemia determines the therapeutic tactics and the need for the appointment of iron-containing drugs.

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The Iron Metabolism in Children Is Normal Also at Infectious Diseases

Cited by 4 publications

References 33 publications

Latent Iron Deficiency in Tender-Age Infants: Modern Preventive Measures

Latent Iron Deficiency in Tender-Age Infants: Modern Preventive Measures

The informativity of the markers of iron metabolism in the differential diagnosis of anemia of inflammation in children with chronic HBV infection

Etiological structure of anemia in HIV-infected children

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