The involvement of the transcription factor Yin Yang 1 in cancer development and progression

Abstract

The Yin Yang 1 (YY1) transcription factor has a pivotal role in normal biological processes such as development, differentiation, replication and cell proliferation exerting its effects on a huge number of genes involved in these processes. Mechanisms of YY1 action are related to its ability to initiate, activate, or repress transcription depending upon the context in which it binds. The role of YY1 played in cancer has been recently explored. This article summarizes the most relevant studies focused on YY1 regulation and dwells on the way how its overexpression may affect the clinical behavior of several cancer types. Furthermore, the contribution of the upregulation of YY1 exerted in response to therapeutic-induced apoptosis is discussed.

Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression

“…2 In absence of certified cell lines from various normal tissues, two preparations of normal fibroblasts were used for comparison. As shown in the representative experiment reported in Figure 2B high YY1 protein expression was observed in the majority of cells lines (A274, A375, CAKI-1, CAKI-2, HT1080, MCF-7, HT-29, HS913T, Currently, DLBCL may be cured in a significant percentage of patients, depending on the initial characteristics of the tumor and the host.…”

“…By gene expression analysis of publicly available datasets from 9 different oncotypes for a total of 552 cancer samples and 276 normal samples, we recently observed that, in several tumor types, YY1 transcript levels were higher when compared to those of the normal counterparts. 2 However, YY1 involvement in hematopoietic malignancies, such as NHL, remains poorly defined.…”

YY1-MIR372-SQSTM1 regulatory axis in autophagy

“…1,2 As named, YY1 can activate or inactivate gene expression depending on its interacting partners and functions as a master of the epigenetic regulatory network. 1 Overexpression of YY1 is observed in various cancers, such as prostate cancer, ovarian cancer, and colon cancer.…”

Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation

“…YY1 is known to have an important role in many biological processes; however, its function in cancer remains controversial (Park and Atchison, 1991;Shi et al, 1991Shi et al, , 1997Gordon et al, 2006;Castellano et al, 2009). Because YY1 positively regulates expression of several oncogenes, that is, E6 and E7, c-Myc, c-Fos and ErbB2 (Riggs et al, 1993;Lee et al, 1995a, b), and negatively regulates p53 stability (Gronroos et al, 2004;Sui et al, 2004), it is believed that YY1 acts as an oncogene (Gordon et al, 2006;Castellano et al, 2009).…”

“…YY1 is a multifunctional protein and is involved in both repression and activation of many genes that have a role in various important biological processes (Shi et al, 1997;Gordon et al, 2006;Castellano et al, 2009). It was shown that YY1 positively regulates expression of several oncogenes, including E6 and E7, c-Myc, c-Fos and ErbB2 (Riggs et al, 1993;Lee et al, 1995a, b).…”