Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression

Castellano, Giancarlo; Torrisi, Elena; Ligresti, Giovanni; Nicoletti, Ferdinando; Malaponte, Grazia; Travali, Salvatore; McCubrey, James A.; Canevari, Silvana; Libra, Massimo

doi:10.4161/cc.9.3.10554

Cited by 48 publications

(45 citation statements)

References 34 publications

(37 reference statements)

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“…10). These conflicting findings mirror previously reported discrepancies in the role of YY1 in lymphoma (Sakhinia et al, 2007;Castellano et al, 2010;Naidoo et al, 2011;Sandison et al, 2013). …”

Section: Bioinformatics Analysis Of Yin Yang 1 Mrna Levelssupporting

confidence: 52%

“…Interestingly, these two reports used the same cohort of patients. Castellano et al (2010) reported the upregulation of YY1 mRNA in high-grade lymphoma, Burkitt and DLBC, compared with normal B cells. The increase of YY1 mRNA was associated with an increase in YY1 protein level in NHL cell lines but not apparent in clinical specimens.…”

Section: Yin Yang 1 Mrna and Protein Expression Levelsmentioning

confidence: 97%

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Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Bonavida

Kaufhold

2015

Pharmacology & Therapeutics

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Section: Bioinformatics Analysis Of Yin Yang 1 Mrna Levelssupporting

confidence: 52%

Section: Yin Yang 1 Mrna and Protein Expression Levelsmentioning

confidence: 97%

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Bonavida

Kaufhold

2015

Pharmacology & Therapeutics

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“…The multi-faceted protein YY1 [5-7, 25, 26] and miRNAs [11, 12] could function either oncogenic or tumor-suppressive roles in the tumorigenesis of hematopoietic malignancies and solid tumors. YY1 was found to cross-talk with miRNAs at least including miR-1 [20], miR-7 [19], miR-29 [15], miR-34a [10, 17, 18], miR-190 [13, 14], and miR-206 [16].…”

Section: Discussionmentioning

confidence: 99%

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

Wang¹,

Huang²,

Hsu³

et al. 2014

Oncotarget

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Gastric cancer is the second leading cause of cancer-related death worldwide. Herein, we investigated the role of transcription factor Yin Yang 1 (YY1), a multi-functional protein, in tumorigenesis of gastric cancer cells. Results showed that YY1 contributed to gastric carcinogenesis of SC-M1 cells including growth, viability, and abilities of colony formation, migration, invasion, and tumorsphere formation. Levels of pluripotency genes CD44, Oct4, SOX-2, and Nanog were also up-regulated by YY1 in SC-M1 cells. Additionally, the 3'-untranslated region (3'-UTR) of YY1 mRNA was the target of microRNA-34 (miR-34) family consisting of miR-34a, miR-34b, and miR-34c. Overexpression of miR-34 family suppressed carcinogenesis through down-regulation of YY1 in NUGC-3 gastric cancer cells scarcely expressing miR-34 family. Alternatively, knockdown of miR-34 family promoted tumorigenesis via up-regulation of YY1 in SC-M1 and AZ521 gastric cancer cells with higher levels of miR-34 family. The miR-34 family also affected tumorsphere ultra-structure and inhibited the xenografted tumor growth as well as lung metastasis of SC-M1 cells through YY1. Expressions of miR-34a and miR-34c in gastric cancer tissues of patients were lower than those in normal tissues. Taken together, these results suggest that miR-34 family-YY1 axis plays an important role in the control of gastric carcinogenesis.

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“…The error bars show the standard deviations of the mean. lymphomas (8), suggesting that YY1 contributes to disease progression.…”

Section: Discussionmentioning

confidence: 99%

YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase Levels

Zaprazna

Atchison

2012

Molecular and Cellular Biology

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Activation-induced deaminase (AID) is an enzyme required for class switch recombination (CSR) and somatic hypermutation (SHM), processes that ensure antibody maturation and expression of different immunoglobulin isotypes. AID function is tightly regulated by tissue-and stage-specific expression, nuclear localization, and protein stability. Transcription factor YY1 is crucial for early B cell development, but its function at late B cell stages is unknown. Here, we show that YY1 conditional knockout in activated splenic B cells interferes with CSR. Knockout of YY1 did not affect B cell proliferation, transcription of the AID and IgM genes, or levels of various switch region germ line transcripts. However, we show that YY1 physically interacts with AID and controls the accumulation of nuclear AID, at least in part, by increasing nuclear AID stability. We show for the first time that YY1 plays a novel role in CSR and controls nuclear AID protein levels.

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Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression

Cited by 48 publications

References 34 publications

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Activation-Induced Deaminase Levels

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