The investigation of the efficacy and safety of stromal vascular fraction in the treatment of nanofat-treated acne scar: a randomized blinded controlled clinical trial

Behrangi, Elham; Moradi, Sepideh; Ghassemi, Mohammadreza; Goodarzi, Azadeh; Hanifnia, Amirreza; Zare, Samad; Nouri, Maryam; Dehghani, Abbas; Seifadini, Azadeh; Nilforoushzadeh, Mohammad Ali; Roohaninasab, Masoumeh

doi:10.1186/s13287-022-02957-2

Cited by 21 publications

(23 citation statements)

References 46 publications

(54 reference statements)

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“…The results of the evaluation after 3 months con rmed a signi cant improvement in sonographic variables such as skin thickness and total skin thickness compared to baseline values at the beginning of the study. In contrast, the improvement in the sonographic variable of epidermis thickness was not signi cant [30]. In our study, the results in the group treated with SVF in combination with fractional CO2 laser con rmed a signi cant improvement in melanin mexameter and Vancouver scar scale compared with fractional CO2 laser alone.…”

Section: Discussioncontrasting

confidence: 61%

“…Among the methods used to treat skin scars in previous studies, the role of fractional CO2 laser should be mentioned [22,23,25,28,29]. Previous studies have also mentioned the e cacy of SVF in the treatment of skin scars [30][31][32]. Our study investigated the e cacy of combining the above two methods compared with using fractional CO2 laser alone for burn scars.…”

Section: Discussionmentioning

confidence: 97%

“…Finally, it is important to mention that several studies have mentioned the e cacy of SVF in the treatment of various diseases as well as different skin lesions, including burn scars and acne scars [30,32,35]. The therapeutic effect of SVF is based on several mechanisms, including angiogenesis, inhibition of apoptosis, and anti-in ammatory effect [39].…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial

Roohaninasab

Khodadad

Sadeghzadeh‐Bazargan

et al. 2023

Preprint

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Background The appearance of skin scars is known as one of the main side effects of skin burns. Stromal vascular fraction (SVF), as a rich source of cell populations with tissue regeneration properties, plays an important role in the healing of skin lesions. Fractional CO2 lasers, have occupied a special place in treating skin lesions, particularly skin scars, since their introduction. Our study aimed to compare the combination of SVF and fractional CO2 laser with fractional CO2 laser alone in the treatment of burn scars. Method This double-blind clinical trial study was conducted on 10 patients with burn scars that were treated three times with a fractional CO2 laser at site of burn lesions, and one of the two areas studied was randomly injected with SVF. Two months after completion of the procedure, patients' scars were assessed using the Vancouver Scar Scale (VSS), biometric criteria, and physician and patient satisfaction ratings. Results The results confirmed a significant improvement in VSS, cutometry, R7 criteria, complete density sonography, and skin density sonography in the fractional CO2 laser- treated group. The VSS criteria, epidermal thickness sonography, complete density sonography, and skin density sonography in the group treated with the combination of fractional CO2 laser and SVF also showed significant improvement. The VSS criteria, and melanin index of Mexameter in the group treated with SVF in combination with fractional CO2 laser were significantly better than the group treated with fractional CO2 laser alone. Also, physician and patient satisfaction in the group treated with SVF injection in combination with fractional CO2 laser was significantly higher than the other group. Conclusion The results confirm the efficacy of SVF injection in combination with fractional CO2 laser in the treatment of burn scars and can be considered as a treatment option for better management of these lesions. The study protocol was registered at Iranian Registry of Clinical Trials with code: IRCT20210515051307N1, Registration date: 2021-11-14, URL: https://www.irct.ir/trial/56337.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial

Roohaninasab

Khodadad

Sadeghzadeh‐Bazargan

et al. 2023

Preprint

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“…The patient selection was done in the hospital to which the authors were affiliated, Tehran, Iran. Sample size was calculated for 10 patients based on the study by Behrangi et al, 19 α = 0.05, statistical power 80%, mean total thickness in the case and control groups equal to 879.43 ± 111.30 and 1051.00 ± 161.84, respectively, and the following formula:

n goodbreak= \frac{{(z_{1 - \frac{a}{2}} + z_{1 - β})}^{2} ()(, δ_{1}^{2} goodbreak+ δ_{2}^{2})}{{()(, μ_{1} goodbreak- μ_{2})}^{2}}

…”

Section: Methodsmentioning

confidence: 99%

Evaluating the effectiveness of stromal‐vascular fraction (SVF) cells along with subcision method in the treatment of acne scars: A double‐blind randomized controlled clinical trial study

Roohaninasab

Seifadini

Atefi

et al. 2022

J of Cosmetic Dermatology

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Background Subcision method is one of the main techniques for treatment of acne scars or stromal‐vascular fraction (SVF) and combined therapy can improve treatment strategy. Objective To use subcision method along with SVF for treatment of acne scar and comprised with alone subcision method. Materials and Methods In this double‐blind clinical trial study, 10 patients with acne scars were entered into the study. Subcision technique was randomly performed on one side of the face and subcision technique plus SVF on opposite side of the face. All patients were examined before treatment and after 3 months by Visioface for volume, area, and depth of scars, as well as thickness and density of the epidermis and dermis of the scars in question. In addition, doctor's and patients' satisfaction, tolerability, and safety were determined after 3 months of treatment. Finally, statistical analysis was done by SPPS, version 25. Results In terms of volume and area of scars, the mean percent change was 46.55 ± 13.92 and 44.60 ± 5.76, for the case group, and 13.31 ± 9.27 and 11.28 ± 9.64 for the control group, respectively. So, combined therapy led to significant recovery compared with alone subcision method (p value < 0.001). In both interventions, the increase of density and thickness was proven after treatment, also a significant difference in complete, epidermal, and dermal thickness and epidermal density variables was observed between combined therapy and alone subcision (p value < 0.05). Mean score of doctor's and patients' satisfaction in combined therapy (7.10 ± 0.74 and 7.10 ± 0.99, respectively), was also significantly higher than subcision alone (5.50 ± 0.53 and 5.30 ± 1.25, respectively). Finally, no complications were observed in the patients. Conclusion According to the acquired results, combined therapy can be considered as effective and safe treatment for acne scars with significant higher efficacy compared with subcision alone.

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“…4,7 The two main components of fat tissue are mature adipose cells and SVF. 9 The patient can be treated in vitro with SVF and cultivated ADSCs. 10 According to recent studies, adipose tissue contains the greatest number of adult stem cells in the body.…”

Section: Ad Ip Os E Tissue and G R Af Ting Techni Q U E Smentioning

confidence: 99%

Fat transplant: Amazing growth and regeneration of cells and rebirth with the miracle of fat cells

Hajimortezayi,

Daei,

Gholizadeh

et al. 2023

J of Cosmetic Dermatology

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Backgrounds and ObjectiveDuring fat transplantation, adipose tissue is removed from the body and injected into different areas under the skin. The goal of this review article is to look into the efficacy and applicability of fat transplantation in regenerative medicine and rejuvenation, including Nanofat, Microfat, and Millifat.MethodsAs a search strategy and study selection, we searched the PubMed and Medline databases until 2023 using related keywords (e.g., Nanofat, Microfat and Millifat, Regenerative Medicine, and Rejuvenation).ResultsAutologous fat transplantation has no risk of an allergic reaction or rejection of the transplant by the individual. Autologous adipose tissue is considered an ideal filler for facial rejuvenation and is suggested as the most biocompatible and non‐immunogenic skin filler. Adipose tissue transplant may have semi‐permanent to permanent effects. According to recent reports, adipose tissues possess a high percentage of mature stem cells. The effect of regenerating adipose tissue and its intrinsic cells can be described as an obvious process. Variations in the sizes of adipose tissues can result in different results depending on the surgical site. Based on topographic assessment, graft fats are assigned depending on the anatomical locations and the size such as Millifat (2–2.5 mm), Microfat (1 mm), and Nanofat (500 μm or less).ConclusionSome characteristics of fat tissue increase its effectiveness, such as increasing stem cells, growth factors, cytokines, and compounds effective in repair, regeneration, and rejuvenation.

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The investigation of the efficacy and safety of stromal vascular fraction in the treatment of nanofat-treated acne scar: a randomized blinded controlled clinical trial

Cited by 21 publications

References 46 publications

Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial

Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial

Evaluating the effectiveness of stromal‐vascular fraction (SVF) cells along with subcision method in the treatment of acne scars: A double‐blind randomized controlled clinical trial study

Fat transplant: Amazing growth and regeneration of cells and rebirth with the miracle of fat cells

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