Evaluating the effectiveness of stromal‐vascular fraction (SVF) cells along with subcision method in the treatment of acne scars: A double‐blind randomized controlled clinical trial study

Abstract

Background Subcision method is one of the main techniques for treatment of acne scars or stromal‐vascular fraction (SVF) and combined therapy can improve treatment strategy. Objective To use subcision method along with SVF for treatment of acne scar and comprised with alone subcision method. Materials and Methods In this double‐blind clinical trial study, 10 patients with acne scars were entered into the study. Subcision technique was randomly performed on one side of the face and subcision technique plus SVF on opposite side of the face. All patients were examined before treatment and after 3 months by Visioface for volume, area, and depth of scars, as well as thickness and density of the epidermis and dermis of the scars in question. In addition, doctor's and patients' satisfaction, tolerability, and safety were determined after 3 months of treatment. Finally, statistical analysis was done by SPPS, version 25. Results In terms of volume and area of scars, the mean percent change was 46.55 ± 13.92 and 44.60 ± 5.76, for the case group, and 13.31 ± 9.27 and 11.28 ± 9.64 for the control group, respectively. So, combined therapy led to significant recovery compared with alone subcision method (p value < 0.001). In both interventions, the increase of density and thickness was proven after treatment, also a significant difference in complete, epidermal, and dermal thickness and epidermal density variables was observed between combined therapy and alone subcision (p value < 0.05). Mean score of doctor's and patients' satisfaction in combined therapy (7.10 ± 0.74 and 7.10 ± 0.99, respectively), was also significantly higher than subcision alone (5.50 ± 0.53 and 5.30 ± 1.25, respectively). Finally, no complications were observed in the patients. Conclusion According to the acquired results, combined therapy can be considered as effective and safe treatment for acne scars with significant higher efficacy compared with subcision alone.

Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial

“…Among the methods used to treat skin scars in previous studies, the role of fractional CO2 laser should be mentioned [22,23,25,28,29]. Previous studies have also mentioned the e cacy of SVF in the treatment of skin scars [30][31][32]. Our study investigated the e cacy of combining the above two methods compared with using fractional CO2 laser alone for burn scars.…”

Investigating the impact of added Profhilo mesogel to subcision versus subcision monotherapy in treating acne scars; a single‐blinded, split‐face randomized trial

“…For acne scars, this procedure is considered safe and uncomplicated. Furthermore, this method is applicable for concurrent use with other treatment modalities 17,18 …”

“…Furthermore, this method is applicable for concurrent use with other treatment modalities. 17,18 The first use of dermal fillers in the treatment of atrophic acne scars was reported by Stegman et al in 1980 using fillers and mesogels in combination with other modalities (such as subcision) has been effective for acne scars. 2,19,20 Various fillers have been used in treating acne scars.…”

A systematic review of the efficacy, safety and satisfaction of regenerative medicine treatments, including platelet‐rich plasma, stromal vascular fraction and stem cell‐conditioned medium for hypertrophic scars and keloids

“…Hypertrophic scars stay within the boundaries of the wound and often regress over time. On the contrary, keloids extend beyond the wound and have a tendency to grow 1–3 …”

“…On the contrary, keloids extend beyond the wound and have a tendency to grow. [1][2][3] To address these types of scars, several treatment options have been proposed. These include corticosteroid injections into the scar tissue, surgical treatments, laser therapy, radiotherapy, as well as newer methods such as bleomycin, interferon and 5-fluorouracil (5-FU) injections.…”