The Investigation of the Effect of Polymer Blending and Radial Fiber Orientation on the Tensile Properties of Electrospun Tubular Vascular Prostheses

Optimization of Electrospun Bilayer Vascular Grafts through Assessment of the Mechanical Properties of Monolayers

“…7 The T h i s c o n t e n t i s structure and material selection of the scaffold has a significant impact on mechanical characteristics such as compliance, tensile strength, and burst resistance, as well as biological properties. 8 Among these points, incompatible dimensional changes between the vascular prostheses and native tissue at the anastomosis sites due to changes in blood pressure, known as "compliance mismatch," is one of the most common problems that results in graft failure. 9 The scaffold's properties affect compliance and burst strength differently as they are two inversely proportional phenomena, so it is particularly difficult to design vascular grafts that are flexible enough to provide both a mechanical reaction resembling that of a native vessel under the influence of pulsatile blood pressure and also resistance to hemodynamic forces.…”

“…The electrospinning method offers great advantages to mimic the natural 3D microenvironment of the ECM and emulate the tunica intima, media, and adventitia of the native artery by achieving the desired fiber morphology, diameter, orientation, porosity, pore size, wall thickness, and multilayer design . The structure and material selection of the scaffold has a significant impact on mechanical characteristics such as compliance, tensile strength, and burst resistance, as well as biological properties . Among these points, incompatible dimensional changes between the vascular prostheses and native tissue at the anastomosis sites due to changes in blood pressure, known as “compliance mismatch,” is one of the most common problems that results in graft failure .…”