The Investigation of Impotence

Jeffcoate, William

doi:10.1111/j.1464-410x.1991.tb15382.x

Cited by 13 publications

(3 citation statements)

References 34 publications

(29 reference statements)

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“…The rate of ED was 10‐fold higher in those in alcohol treatment facilities than in abstainers (71% vs. 7% [10]). On the other side, 6.5% to 13% of men diagnosed with ED in different specialized clinics suffer also from alcohol abuse or chronic alcoholism [11–15]. Clinical observations of men in remission show that after being withdrawn from alcohol, they complain of impotence and report it as a “cause” for relapse or justify by it their relapse [16,17].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Psychosocial Factors Associated with Quality of Life in Alcohol-Dependent Men with Erectile Dysfunction

Ponizovsky¹

2008

The Journal of Sexual Medicine

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Introduction Men with alcohol dependence (AD) commonly suffer from alcohol-induced sexual (erectile) dysfunction (ED) and have poor quality of life (Qol). Knowledge about the factors associated with Qol in such patients is lacking. Aim To identify in men who sought medical help for both AD and ED the variables that best predicted feelings of satisfaction with life and with specific life domains. Main Outcome Measures The Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q). Secondary study measures were the International Index of Erectile Function (IIEF), Beck Depression Inventory (BDI-13), General Health Questionnaire (GHQ-12), Rosenberg's General Self-Esteem Scale (RGSES), and the Multidimensional Scale of Perceived Social Support (MSPSS). Methods Within an open-label sildenafil trial, 101 men aged 18–50 years with an International Classification of Diseases, Tenth Edition diagnosis of AD and concomitant ED were interviewed and completed the questionnaires. Multivariate analyses were applied to establish predictors of life satisfaction and factors mediating the relation between ED and life satisfaction. Results ED and self-rated depressive symptoms, emotional distress, self-esteem, and perceived social support were found to be significantly associated with Qol and its component domains. Altogether they explained 18–38% of the variance in the Qol ratings. Depressive symptomatology, distress, and self-esteem, individually, demonstrated a mediating effect on the relation between ED and Qol. Finally, self-esteem was shown to be the primary mediator in this relationship. Conclusion The results of the study show that self-esteem is the primary factor, and depressive symptoms and severe emotional distress are secondary factors mediating the effects of ED on Qol in male patients seeking medical help for both AD and ED. An integrated pharmacopsychosocial approach targeting the underlying ED as well as the mediating emotional conditions could improve Qol of these patients and thus help them to stop using alcohol.

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Section: Introductionmentioning

confidence: 99%

Clinical and Psychosocial Factors Associated with Quality of Life in Alcohol-Dependent Men with Erectile Dysfunction

Ponizovsky¹

2008

The Journal of Sexual Medicine

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“…It is likely that poor corporeal compliance or arterial inflow was contributory to their erectile failure. Without an adequate inflow, intracorporéal pressure will not rise, precluding the efficient compression of corporeal emissary veins and effectively creating a venous leak [12]. PIPE presumably corrects this deficit.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Venous Leakage: Medium-Term Follow-Up

McLoughlin¹,

Asopa²,

Williams³

1993

Eur Urol

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“…Studies conducted by Jeffcoate et al [15] and McCambridge et al [19] show that men with ED are frequently chronic alcohol addicts. The findings of previous studies show that modest ethanol doses (e.g., at blood concentrations of 100 mg/dl) can both increase sexual drive and decrease erectile capacity in men [4].…”

Section: Introductionmentioning

confidence: 99%

UV-vis spectroscopic study of lipid peroxidation and antioxidant contents of kidney of Albino mice co-administrated with sildenafil citrate and alcohol

2011

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Abstract. Male Wistar Albino mice were co-administrated with appropriate dose of sildenafil citrate and alcohol. The kidney samples of those animals were analyzed for lipid peroxidation and antioxidant contents. Lipid peroxidation was measured based on TBARS. Antioxidant such as SOD, CAT, GPx and GSH were also determined. From the present investigation, an enhanced level of TBARS accompanied by a decreased concentration of enzymic as well as non-enzymic antioxidants in kidney was detected for 30 days animals treated concomitantly with sildenafil citrate and alcohol. Increased level of lipid peroxidation lead to accumulation of free radicals and increased oxidative threat in kidney tissues. Also, the decreased concentration of antioxidant enzymes in renal tissues indicates the failure of antioxidant defence system.

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The Investigation of Impotence

Cited by 13 publications

References 34 publications

Clinical and Psychosocial Factors Associated with Quality of Life in Alcohol-Dependent Men with Erectile Dysfunction

Clinical and Psychosocial Factors Associated with Quality of Life in Alcohol-Dependent Men with Erectile Dysfunction

Surgical Treatment of Venous Leakage: Medium-Term Follow-Up

UV-vis spectroscopic study of lipid peroxidation and antioxidant contents of kidney of Albino mice co-administrated with sildenafil citrate and alcohol

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