The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

Bıçak, Damla Akşit; Akyüz, Serap; Kıratlı, Binnur; Usta, Merve; Urgancı, Nafiye; Alev, Burçin; Yarat, Ayşen; Şahın, Fikrettin

doi:10.1186/s12903-017-0361-x

Cited by 38 publications

(37 citation statements)

References 61 publications

(102 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors observed that H. pylori can occur in the oral cavity aside and independently of the stomach. They also found an association between the presence of H. pylori and halitosis …”

Section: Invasive Testsmentioning

confidence: 89%

Diagnosis of Helicobacter pylori infection

2018

View full text Add to dashboard Cite

The progress this year in Helicobacter pylori diagnosis concerned essentially endoscopy and molecular techniques. New endoscopy techniques such as blue laser imaging and magnifying narrow band imaging allow the visualization of mucosal aspects representing H. pylori infection, intestinal metaplasia, and even ambiguous early gastric cancer. Several real-time PCRs have also been used either to quantify H. pylori or to detect mutations associated with clarithromycin resistance in gastric biopsies or applied on gastric juice, stool specimens, or the oral cavity. The presence of H. pylori in free-living amebae purified from wastewater and drinking water was also determined by PCR and sequencing, as well as culture from a few wastewater samples. Among the noninvasive methods, the urea breath test was used in different conditions, including with a new test meal, which is claimed to avoid the proton-pump inhibitor washout period before testing. Several articles concerning antibody detection and stool antigen test were also published.

show abstract

“…The authors observed that H. pylori can occur in the oral cavity aside and independently of the stomach. They also found an association between the presence of H. pylori and halitosis …”

Section: Invasive Testsmentioning

confidence: 89%

Diagnosis of Helicobacter pylori infection

2018

View full text Add to dashboard Cite

show abstract

“…[ 39 ] observed that after eradication of H. pylori with 3 antibiotic treatment, most of the patients had decreased halitosis in long-term follow-ups. In another study [ 40 ], organoleptic scoring and the BANA test were both used to evaluate halitosis among gastric H. pylori positive and negative children. According to organoleptic scoring and BANA test, there was no clear relationship found between the gastric presence of H. pylori and halitosis.…”

Section: Literature Review/ Discussionmentioning

confidence: 99%

A Current Approach to Halitosis and Oral Malodor- A Mini Review

Bıçak¹

2018

TODENTJ

View full text Add to dashboard Cite

Background:Halitosis, in other words, oral malodor is an important multifactorial health problem affecting the psychological and social life of individuals and is the most common reason for referral to dentists after dental caries and periodontal diseases.Objective:The objective of this review was to present and discuss conventional and recently introduced information about the types, causes, detection and treatment methods of halitosis.Methods:An expanded literature review was conducted which targeted all articles published in peer-reviewed journals relating to the topic of halitosis. Only articles written in Turkish and English languages were considered. The review itself began with a search of relevant subject headings such as ‘halitosis, oral malodor, volatile sulfur compounds in PubMed/Medline, Scopus, Google Scholar and Tubitak Ulakbim databases. A hand search of references was also performed.Results:When search results are combined, the total number of relevant literature was found to be 4646 abstracts and 978 full-text articles. Abstracts, editorial letters were not included and about half of full-text articles were not related to dental practice. Among the remaining 124 full-text articles, duplicated articles and articles written other than Turkish and English languages were removed and 54 full-text articles were used for this review.Discussion:According to the reviewed articles, both conventional and new methods were introduced in the management of halitosis. However, conventional methods seem to be more effective and widely used in the diagnosis and treatment of halitosis.Conclusion:As being first line professionals, dentists must analyze and treat oral problems which may be responsible for the patient's malodor, and should inform the patient about halitosis causes and oral hygiene procedures (tooth flossing, tongue cleaning, appropriate mouthwash and toothpaste selection and use) and if the problem persists, they should consult to a medical specialist.

show abstract

“…Some epidemiological studies have revealed that patients with dental caries or poor oral hygiene were more likely to harbour H. pylori in oral cavity or gastric tissue 13 , 14 . These findings suggest that the presence of cariogenic bacteria is involved in infection of the oral cavity with H. pylori .…”

Section: Introductionmentioning

confidence: 99%

Contribution of Streptococcus mutans to Helicobacter pylori colonisation in oral cavity and gastric tissue

Nomura

Kadota

Ogaya

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as well as gastric tissue. Rats in the weaning period were infected with S. mutans in the oral cavity, then fed a caries-inducing diet to facilitate S. mutans colonisation. One month after S. mutans infection, rats were infected with H. pylori in the oral cavity; rats were then euthanised at 1 month after H. pylori infection. H. pylori was detected in the oral cavities of rats infected with both S. mutans and H. pylori, but not in rats infected with H. pylori alone. In addition, H. pylori colonisation in the gastric tissue and typical gastrointestinal damage were observed in rats infected with both S. mutans and H. pylori. When H. pylori was co-cultured with in vitro biofilm formed by S. mutans, a large number of H. pylori bacteria invaded the biofilm formed by S. mutans. Our results suggest that S. mutans is involved in the establishment of H. pylori infection. Helicobacter pylori, a helix-shaped gram-negative microaerophilic bacterium, is a major causative agent of gastric cancer and gastric ulcers 1. More than half of the world's population is infected with H. pylori 2 , which is presumably acquired mainly via the oral cavity in childhood 3,4. Molecular biological techniques have reportedly revealed H. pylori in oral specimens 5-7. The presence of H. pylori in the oral cavity has been related to the detection of H. pylori in the gastric tissue 8. However, details regarding risk factors of H. pylori infection in the oral cavity have not been clarified, which may explain the current difficulty in elimination of H. pylori infection. Streptococcus mutans, a gram-positive facultative anaerobe, is a major causative pathogen of dental caries 9. S. mutans is acquired in the oral cavity during early childhood, mainly via mother-to-child transmission 10. The aetiology of dental caries caused by S. mutans was clarified in the early 1960s 11 ; S. mutans metabolises sucrose to form a biofilm on the tooth surface, followed by demineralisation of the tooth. Nevertheless, eradication of S. mutans from the oral cavity and dental caries remains difficult 12. Some epidemiological studies have revealed that patients with dental caries or poor oral hygiene were more likely to harbour H. pylori in oral cavity or gastric tissue 13,14. These findings suggest that the presence of cariogenic bacteria is involved in infection of the oral cavity with H. pylori. To the best of our knowledge, no clear evidence has been obtained regarding the effects of S. mutans on H. pylori infection in an animal model. In the present study, we hypothesised that S. mutans colonisation in the oral cavity may be involved in H. pylori colonisation in both oral cavity and gastric tissue. Therefore, we constructed a rat co-infection model with S. mut...

show abstract

The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints

Cited by 38 publications

References 61 publications

Diagnosis of Helicobacter pylori infection

Diagnosis of Helicobacter pylori infection

A Current Approach to Halitosis and Oral Malodor- A Mini Review

Contribution of Streptococcus mutans to Helicobacter pylori colonisation in oral cavity and gastric tissue

Contact Info

Product

Resources

About