Purpose: This study was carried out to determine the effect of nurses' compassion on burnout. Design and Methods: This cross-sectional descriptive study was conducted with 177 nurses. An introductory information form, the compassion scale and the Maslach burnout inventory were used as the data collection tools. Frequency, percentage, t test, analysis of variance, Kruskal-Wallis, correlation, and regression were used in the analysis of the data. Findings: The majority of the participants were determined to be female, married and university graduates. It was determined that there was a significant negative relationship between the nurses' sense of compassion and burnout levels, and burnout decreased as compassion increased. Practical Implication: Burnout and compassion fatigue may lead to inadequate care for the patient. This situation will negatively influence nurses' care quality.