The “inverted cup” — A novel in vitro release technique for drugs in lipid formulations

Söderberg, Lars; Dyhre, Henrik; Roth, Bodil; Björkman, Sven

doi:10.1016/j.jconrel.2006.03.015

Cited by 10 publications

(9 citation statements)

References 26 publications

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“…The Binverted cup^method, as described by Soderberg et al, was used with some modifications, to study the drug release from the depot formulations (44). Briefly, the formulation was introduced in an inverted cup, through a hole, by the means of a 1-mL syringe.…”

Section: In-vitro Dtx Release Study From Depot Formulationmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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Abstract. The aim of the present study was to develop and evaluate a thermoresponsive depot system comprising of docetaxel-loaded cubosomes. The cubosomes were dispersed within a thermoreversible gelling system for controlled drug delivery. The cubosome dispersion was prepared by dilution method, followed by homogenization using glyceryl monooleate, ethanol and Pluronic ® F127 in distilled water. The cubosome dispersion was then incorporated into a gelling system prepared with Pluronic ® F127 and Pluronic ® F68 in various ratios to formulate a thermoresponsive depot system. The thermoresponsive depot formulations undergo a thermoreversible gelation process i.e., they exists as free flowing liquids at room temperature, and transforms into gels at higher temperatures e.g., body temperature, to form a stable depot in aqueous environment. The mean particle size of the cubosomes in the dispersion prepared with Pluronic ® F127, with and without the drug was found to be 170 and 280 nm, respectively. The prepared thermoresponsive depot system was evaluated by assessing various parameters like time for gelation, injectability, gel erosion, and in-vitro drug release. The drug-release studies of the cubosome dispersion before incorporation into the gelling system revealed that a majority (∼97%) of the drug was released within 12 h. This formulation also showed a short lag time (∼3 min). However, when incorporated into a thermoresponsive depot system, the formulation exhibited an initial burst release of ∼21%, and released only ∼39% drug over a period of 12 h, thus indicating its potential as a controlled drug delivery system.

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Section: In-vitro Dtx Release Study From Depot Formulationmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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“…21,22,28,29 The animals were briefly anesthetized with halothane, 2% to 3% in oxygen, by facemask. The sciatic nerve on one side was surgically exposed.…”

Section: Sciatic-nerve Blockmentioning

confidence: 99%

“…In the absence of nerve block, the rats withdrew the paw within 3 seconds. 21,22,28,29 Consequently, partial block was defined as a withdrawal latency of 4 to 10 seconds. The duration of sensory block is given as the time from injection of the test formulation to the last occurrence of full and partial block, respectively.…”

Section: Sciatic-nerve Blockmentioning

confidence: 99%

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Local Anesthetics in Lipid-Depot Formulations—Neurotoxicity in Relation to Duration of Effect in a Rat Model

Dyhre

Söderberg

Björkman

et al. 2006

Regional Anesthesia and Pain Medicine

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The findings suggest that depot formulations of local anesthetics with advantageous pharmaceutical and pharmacologic properties can be prepared by use of bupivacaine as the active component and natural lipids as carriers. A favorable balance between effects and toxicity may conceivably be obtained. After supplemental testing in more sensitive models for toxicity, such formulations could be candidates for clinical trials.

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“…As in any liquid delivery system, the interfacial area between the vehicle and the release media is a critical factor affecting the rate and extent of drug release [ 112 ] . For lipophilic solutions, the oil-water interphase largely determines the release kinetics and should remain constant throughout the release study.…”

Section: Special Case: In Vitro Release From Lipophilic Solutionsmentioning

confidence: 99%

In Vitro Drug Release Testing and In Vivo/In Vitro Correlation for Long Acting Implants and Injections

Kastellorizios

Burgess

2011

Long Acting Injections and Implants

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An advantage of long acting implants and injections is their ability to maintain a relatively constant drug concentration at the site of interest. In vitro drug release testing, particularly where an in vivo / in vitro relationship has been established, can help in ensuring in vivo performance. There are various in vitro release testing methods, which are chosen, based on availability, dosage form specifi cations and drug properties. These are categorized into three groups: sample and separate, fl ow-through and dialysis. Although there are currently no standard methods for in vitro release testing of controlled release parenterals, standard dissolution apparatus specifi ed by the United States Pharmacopeia have been adapted in some cases and the development of compendial monographs is anticipated. An in vivo / in vitro correlation can predict the bioavailability characteristics of a product based on release in vitro .

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The “inverted cup” — A novel in vitro release technique for drugs in lipid formulations

Cited by 10 publications

References 26 publications

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Local Anesthetics in Lipid-Depot Formulations—Neurotoxicity in Relation to Duration of Effect in a Rat Model

In Vitro Drug Release Testing and In Vivo/In Vitro Correlation for Long Acting Implants and Injections

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