“…36,72,84,85,91,92,153,183 Excess amount of copper (free) could be detrimental to respiratory chain reactions and generation of toxic hydroxyl radicals (HO 0 ) causing oxidative damage not only to mitochondria, but also other extracellular-intracellular proteins or nucleic acids and lipids (Fenton reaction) and tissue oxido-redox potentials. 1,5,14,20,29,[31][32][33][34][35][36][37][38][39]53,55,72,73,78,84,85,[88][89][90][91][92]155,182,183 Furthermore, copper and Zn +2 (another trace element and antioxidant) are involved in detoxifying mitochondrial ROS and superoxide dismutase1 (SOD1) activities, regulation of Cu-mediated production of O 2 /ROS. Related studies suggest that trace elements (Cu, zinc, Fe), influence regulations of transport of triglycerides in gastrointestinal tract and are important in the function of red blood cells and endoplasmic reticulum activities.…”