The intratumoral microbiome: Characterization methods and functional impact

Heymann, Clément J.F.; Bard, Jean‐Marie; Heymann, Marie-Françoise; Heymann, Dominique; Bobin‐Dubigeon, Christine

doi:10.1016/j.canlet.2021.09.009

Cited by 30 publications

(26 citation statements)

References 143 publications

(225 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such Gram-negative bacteria may contribute to the tumour ecosystem in absence of active infection. These bacteria are not proliferating and must be considered as symbiotic partners which may participate in the control of the local immunity [4] , [7] . Their non-proliferative property makes difficult their detection.…”

Section: Discussionmentioning

confidence: 99%

“…Tumours possess all the required properties to support high bacterial prevalence. In complement to the natural ability of cancer cells to hide from host immune surveillance, the abundant vasculature surrounding tumours make them perfect lying spots for circulating bacteria [6] , [7] . Likewise, tumour necrotic regions also release high levels of nutrients (e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Heymann

Bobin‐Dubigeon

Garcia

et al. 2022

Journal of Bone Oncology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Heymann

Bobin‐Dubigeon

Garcia

et al. 2022

Journal of Bone Oncology

Self Cite

View full text Add to dashboard Cite

“…Although microbiota in all barriers contributes to the local immune response, the gut microflora is mainly responsible for the microbiota's systemic influence [ 147 ]. Also, due to the specific features of tumor tissue like hypoxia, abundant nutrients, immune evasion strategies served by cancer cells, and neoangiogenesis, the tumor microenvironment can be a supportive and immune-protected site for bacterial colonization, as proposed by Heymann et al [ 148 ]. These intra-tumoral bacteria could influence the tumor infiltrated immune cells.…”

Section: Impacts Of Microbiota On Anti-tumor Immunity and Therapymentioning

confidence: 99%

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

et al. 2022

View full text Add to dashboard Cite

In recent years, there has been a greater emphasis on the impact of microbial populations inhabiting the gastrointestinal tract on human health and disease. According to the involvement of microbiota in modulating physiological processes (such as immune system development, vitamins synthesis, pathogen displacement, and nutrient uptake), any alteration in its composition and diversity (i.e., dysbiosis) has been linked to a variety of pathologies, including cancer. In this bidirectional relationship, colonization with various bacterial species is correlated with a reduced or elevated risk of certain cancers. Notably, the gut microflora could potentially play a direct or indirect role in tumor initiation and progression by inducing chronic inflammation and producing toxins and metabolites. Therefore, identifying the bacterial species involved and their mechanism of action could be beneficial in preventing the onset of tumors or controlling their advancement. Likewise, the microbial community affects anti-cancer approaches’ therapeutic potential and adverse effects (such as immunotherapy and chemotherapy). Hence, their efficiency should be evaluated in the context of the microbiome, underlining the importance of personalized medicine. In this review, we summarized the evidence revealing the microbiota's involvement in cancer and its mechanism. We also delineated how microbiota could predict colon carcinoma development or response to current treatments to improve clinical outcomes.

show abstract

“…With advances in sequencing technology, the presence of microbes within tumors has been identified. Studies show that each cancer subtype has a unique microbiome with specific metabolic functions, and the intratumor bacteria are mostly present in both cancer and immune cells ( 2 , 60 ). Therefore, the intratumoral microbiome plays a crucial role in tumor development and treatment.…”

Section: Carcinogenic Microorganism Infections Microbial Disorders An...mentioning

confidence: 99%

“…The microbiota lives on all the epithelial surfaces of the human body, including the skin, respiratory tract, digestive tract, and urogenital tract, and their presence can be detected even within tumors ( 1 , 2 ). Hundreds of millions of years of evolution have established a lasting relationship between the microbiome and the human body ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Microbiome in cancer: An exploration of carcinogenesis, immune responses and immunotherapy

Zhou

Wang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Cancer is a major disease endangering human health. More and more studies have shown that microorganisms play an extremely important role in the occurrence, development and treatment of tumors. As a very promising tumor treatment strategy, immunotherapy has also been proved to have a great relationship with microorganisms. Here, the authors review the contribution of the microbiota to cancer and the research on its impact on cancer immunotherapy. We also highlight the possible mechanism of their interaction and outlined the potential application of microbiota in tumor immunotherapy.

show abstract

The intratumoral microbiome: Characterization methods and functional impact

Cited by 30 publications

References 143 publications

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

Microbiome in cancer: An exploration of carcinogenesis, immune responses and immunotherapy

Contact Info

Product

Resources

About