Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Heymann, Clément J.F.; Bobin‐Dubigeon, Christine; Garcia, Javier-Muñoz; Cochonneau, Denis; Ollivier, Emilie; Heymann, Marie-Françoise; Heymann, Dominique

doi:10.1016/j.jbo.2022.100451

Cited by 8 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another relevant biomarker is represented by an increase in LPS concentrations, particularly in subjects with complicated CVID ( 17 , 27 , 43 ). Recent evidence has demonstrated that LPS can favor the onset of cancer ( 89 , 90 ) and the formation of metastasis ( 91 , 92 ). These observations suggest that persistent elevation of proinflammatory cytokines and LPS concentrations, despite IgRT, could contribute to chronic inflammation, favoring the onset of solid and hematologic cancers in CVID subjects.…”

Section: Discussionmentioning

confidence: 99%

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

Poto,

Pecoraro,

Ferrara

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionCommon variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underlying immune dysregulation.MethodsIn this study, we evaluated the serum concentrations of proinflammatory (TNF-α, IL-1β, IL-6) and immunoregulatory cytokines (IL-10), as well as lipopolysaccharide (LPS) and soluble CD14 (sCD14) in CVID individuals with infectious only (INF-CVID), and those with additional systemic autoimmune and inflammatory disorders (NIC-CVID), and healthy donors (HD).ResultsOur results showed increased serum concentrations of TNF-α, IL-1β, IL-6, and IL-10 in both INF-CVID and NIC-CVID subjects compared to HD. However, elevations of TNF-α, IL-1β, IL-6, and IL-10 were significantly more marked in NIC-CVID than INF-CVID. Additionally, LPS concentrations were increased only in NIC-CVID but not in INF-CVID compared to HD. Circulating levels of sCD14 were significantly increased in NIC-CVID compared to both INF-CVID and HD.DiscussionThese findings indicate persistent cytokine dysregulation despite IgRT in individuals with CVID. Moreover, the circulating cytokine profile reveals the heterogeneity of immune dysregulation in different subgroups of CVID subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

Poto,

Pecoraro,

Ferrara

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Advanced OS has highly heterogeneous histological patterns and is associated with an immunosuppressive microenvironment, which comprises cancer-associated fibroblasts, tumor-associated macrophages, vascular and perivascular cells, mesenchymal stem cells, dendritic cells, neutrophils, and CD4 + and CD8 + tumor-infiltrating lymphocytes, FoxP3 + T regs, B lymphocytes, and NK cells [ 12 , 17 ••, 75 – 77 ]. More recently, tumor-specific intracellular bacteria have been shown to enrich the tumor microenvironment of osteosarcoma [ 78 ••, 79 ]. The pulmonary metastatic microenvironment is characterized by a higher infiltration of T cells and relatively lower myeloid cells than primary bone tumors and higher expressions of inhibitory checkpoints, such as TIM-3, Lag-3, and IDO1 [ 72 ].…”

Section: Role Of the Tumor Microenvironment In Os Drug Resistancementioning

confidence: 99%

Advances in Osteosarcoma

Panez-Toro,

Muñoz-García,

Vargas-Franco

et al. 2023

Curr Osteoporos Rep

Self Cite

View full text Add to dashboard Cite

Purpose of Review This article gives a brief overview of the most recent developments in osteosarcoma treatment, including targeting of signaling pathways, immune checkpoint inhibitors, drug delivery strategies as single or combined approaches, and the identification of new therapeutic targets to face this highly heterogeneous disease. Recent Findings Osteosarcoma is one of the most common primary malignant bone tumors in children and young adults, with a high risk of bone and lung metastases and a 5-year survival rate around 70% in the absence of metastases and 30% if metastases are detected at the time of diagnosis. Despite the novel advances in neoadjuvant chemotherapy, the effective treatment for osteosarcoma has not improved in the last 4 decades. The emergence of immunotherapy has transformed the paradigm of treatment, focusing therapeutic strategies on the potential of immune checkpoint inhibitors. However, the most recent clinical trials show a slight improvement over the conventional polychemotherapy scheme. Summary The tumor microenvironment plays a crucial role in the pathogenesis of osteosarcoma by controlling the tumor growth, the metastatic process and the drug resistance and paved the way of new therapeutic options that must be validated by accurate pre-clinical studies and clinical trials.

show abstract

“…Intratumoral microbes can retard cancer development by augmenting antitumor immunity. Gram-negative bacteria were detected in the cytoplasm of osteosarcoma cells and tumorassociated macrophages (TAMs) (74). Osteosarcoma tissues from patients with local diseases were enriched in Gram-negative bacteria compared with those from patients with metastatic status.…”

Section: Enhancement Of Antitumor Immunitymentioning

confidence: 99%

Intratumor microbiota in cancer pathogenesis and immunity: from mechanisms of action to therapeutic opportunities

Wang,

Yu,

2023

Front. Immunol.

View full text Add to dashboard Cite

Microbial species that dwell human bodies have profound effects on overall health and multiple pathological conditions. The tumor microenvironment (TME) is characterized by disordered vasculature, hypoxia, excessive nutrition and immunosuppression. Thus, it is a favorable niche for microbial survival and growth. Multiple lines of evidence support the existence of microorganisms within diverse types of cancers. Like gut microbiota, intratumoral microbes have been tightly associated with cancer pathogenesis. Intratumoral microbiota can affect cancer development through various mechanisms, including induction of host genetic mutation, remodeling of the immune landscape and regulation of cancer metabolism and oncogenic pathways. Tumor-associated microbes modulate the efficacy of anticancer therapies, suggesting their potential utility as novel targets for future intervention. In addition, a growing body of evidence has manifested the diagnostic, prognostic, and therapeutic potential of intratumoral microorganisms in cancer. Nevertheless, our knowledge of the diversity and biological function of intratumoral microbiota is still incomplete. A deeper appreciation of tumor microbiome will be crucial to delineate the key pathological mechanisms underlying cancer progression and hasten the development of personalized treatment approaches. Herein, we summarize the most recent progress of the research into the emerging roles of intratumoral microbiota in cancer and towards clarifying the sophisticated mechanisms involved. Moreover, we discuss the effect of intratumoral microbiota on cancer treatment response and highlight its potential clinical implications in cancer.

show abstract

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Cited by 8 publications

References 40 publications

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

Advances in Osteosarcoma

Intratumor microbiota in cancer pathogenesis and immunity: from mechanisms of action to therapeutic opportunities

Contact Info

Product

Resources

About