The intraperitoneal bacteriology and antimicrobial resistance in acute appendicitis among children: a retrospective cohort study between the years 2007–2017

Dabaja‐Younis, Halima; Farah, Hanna; Miron, Ran; Geffen, Yuval; Slijper, Nadav; Steinberg, Ran; Kassis, Imad

doi:10.1007/s00431-021-03994-4

Cited by 4 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the knowledge of the most common bacteria which are implicated in this process is of great value. The bacterial flora of the appendix and/or the peritoneal cavity in children with acute appendicitis has been described in numerous studies [18,[34][35][36][37][38][39][40][41][42][43][44][45][46]. The association between certain bacteria and the stage of appendicitis has been investigated as well [18,34,35,39,42,43,45,46].…”

Section: Discussionmentioning

confidence: 99%

“…The bacterial flora of the appendix and/or the peritoneal cavity in children with acute appendicitis has been described in numerous studies [18,[34][35][36][37][38][39][40][41][42][43][44][45][46]. The association between certain bacteria and the stage of appendicitis has been investigated as well [18,34,35,39,42,43,45,46]. Traditional culture techniques [18,[34][35][36][37][38][39][40], culture-independent methods like rRNA or rDNA gene sequencing [41][42][43][44][45], or both [46], have been used to investigate the microbial content and its role in the different grades of appendicitis.…”

Section: Discussionmentioning

confidence: 99%

“…The association between certain bacteria and the stage of appendicitis has been investigated as well [18,34,35,39,42,43,45,46]. Traditional culture techniques [18,[34][35][36][37][38][39][40], culture-independent methods like rRNA or rDNA gene sequencing [41][42][43][44][45], or both [46], have been used to investigate the microbial content and its role in the different grades of appendicitis. Supporters of the gene sequencing studies reported that traditional cultures failed to identify the majority of the microorganisms [39], as children with acute appendicitis presented an abundance of the genera Fusobacteria and a decrease of the genera Bacteroides, compared to controls [42,44].…”

Section: Discussionmentioning

confidence: 99%

“…Traditional culture techniques [18,[34][35][36][37][38][39][40], culture-independent methods like rRNA or rDNA gene sequencing [41][42][43][44][45], or both [46], have been used to investigate the microbial content and its role in the different grades of appendicitis. Supporters of the gene sequencing studies reported that traditional cultures failed to identify the majority of the microorganisms [39], as children with acute appendicitis presented an abundance of the genera Fusobacteria and a decrease of the genera Bacteroides, compared to controls [42,44]. These studies reported association with severity of inflammation, but they did not reach statistical significance and did not assign causality [42,44].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the theory that gene sequencing techniques cannot distinguish between viable and non-viable bacteria, other studies preferred traditional cultures, after collecting fluid from the peritoneal cavity [18,[34][35][36][37][38][39][40]. Schülin, et al collected samples from the lumen of the appendix [46].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children

Zachos¹,

Kolonitsiou²,

Panagidis³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Primary infection has been questioned as the pathogenetic cause of acute appendicitis. We attempted to identify the bacteria involved, and to investigate if their species, types, or combinations affected the severity of acute appendicitis in children. Methods: Samples from both the appendiceal lumen and the peritoneal cavity of 72 children who underwent appendectomy were collected to perform bacterial culture analysis. The outcomes were studied to see if and how they were associated with the severity of the disease. Regression analysis was performed to identify any risk factors associated with complicated appendicitis. Results: Escherichia coli, Pseudomonas aeruginosa and Streptococcus species were the most common pathogens found in the study population. The same microorganisms, either combined or separate, were the most common in the appendiceal lumen and the peritoneal cavity of patients with complicated appendicitis. Gram-negative bacteria, polymicrobial cultures in the peritoneal fluid and in the appendiceal lumen, were associated with complicated appendicitis. Polymicrobial cultures in the peritoneal cavity presented four times higher risk of complicated appendicitis. Conclusion: Polymicrobial presentation and gram-negative bacteria are associated with complicated appendicitis. Antibiotic regimens should target the combinations of the most frequently identified pathogens, speculating the value of early antipseudomonal intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children

Zachos¹,

Kolonitsiou²,

Panagidis³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Using Microbiology Culture in Pediatric Appendicitis to Risk Stratify Patients: A Cohort Study

Martin

Subramanian

Arul

et al. 2023

Surgical Infections

View full text Add to dashboard Cite

Clinical, Laboratory and Radiographic Features Associated With Prolonged Hospitalization in Children With Complicated Appendicitis

et al. 2022

View full text Add to dashboard Cite

ObjectiveIn children with appendicitis, rupture of the appendix is associated with a significant increase in morbidity. We sought to characterize the spectrum of illness in children with complicated appendicitis and to define those factors associated with a longer hospital stay.Study DesignWe conducted a retrospective review of 132 children, 18 years of age or younger at a large urban teaching hospital in the Bronx, NY between October 2015 and April 2018 with an intraoperative diagnosis of perforated appendix. Clinical, laboratory and radiologic findings were reviewed, and the primary study outcome was length of stay (LOS) dichotomized at the median, which was 7 days. Statistical analyses were done to characterize morbidity and define variables predictive of longer stay.ResultsChildren in the longer LOS group experienced significantly more morbidity, including ICU stay, ileus, and need for multiple drainage procedures. A longer duration of symptoms prior to presentation was associated with a longer stay. Multivariable logistic regression analysis indicated that the presence of abscess and presence of free fluid in the right upper quadrant (RUQ FF) on initial imaging and C-reactive protein (CRP) level >12 at admission, were independently associated with a longer stay.ConclusionThere is considerable variation in the morbidity of complicated appendicitis. The association between longer stay and the findings of abscess and RUQ FF on initial imaging along with an elevated CRP may provide a useful tool in identifying those children at risk for worse outcomes.

show abstract

The intraperitoneal bacteriology and antimicrobial resistance in acute appendicitis among children: a retrospective cohort study between the years 2007–2017

Cited by 4 publications

References 20 publications

Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children

Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children

Using Microbiology Culture in Pediatric Appendicitis to Risk Stratify Patients: A Cohort Study

Clinical, Laboratory and Radiographic Features Associated With Prolonged Hospitalization in Children With Complicated Appendicitis

Contact Info

Product

Resources

About