The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment

Abstract

This is a repository copy of The intracellular number of magnetic nanoparticles modulates the apoptotic death pathway after magnetic hyperthermia treatment.

Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era

“…Beola et al demonstrated that, depending on the concentration of the SPIONs, the AMF stimulation might trigger extrinsic (e.g., caspase-8-mediated apoptosis) or intrinsic (e.g., increased Bax/bcl-2 ratio) death pathways. 71 In particular, they showed that at the lowest SPION concentrations tested, the AMF stimulus triggered a decrease of B-cell lymphoma 2 (Bcl-2) mRNA expression and a contextual overexpression of the Bcl-2 associated X protein (Bax) mRNA levels, with consequent increase of the Bax/Bcl-2 ratio. Bax (pro-apoptotic) and Bcl-2…”

How size, shape and assembly of magnetic nanoparticles give rise to different hyperthermia scenarios

“…Another key aspect defining the heating performance is the particle assembling, as it is often observed that particles tend to aggregate after cell internalisation, 41 which may completely define their heat release in comparison with the randomly dispersed case. [42][43][44][45] The assembling process is defined by a complex interplay between a broad range of parameters, including the media properties (viscosity, pH), the nanoparticle characteristics (size, shape, anisotropy), the field parameters (frequency and amplitude) and, obviously, the sample concentration see e.g. Bakuzis et al and references therein.…”

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

“…[12,13] The deep penetration of magnetic fields within the human body, together with the possibility of targeting MNPs to specific tissues, have enabled minimally invasive, local, and remotely activated heating showing high efficacy at the in vitro and in vivo levels. [14][15][16][17][18][19][20][21][22][23] Clinical trials have shown the efficacy of MHT to treat solid tumors, as well as to increase the usefulness of chemotherapy by enhancing drug permeability of cancer tissues. [24,25] Reaching high standards of efficacy and selectivity in MHT treatments requires full control over the remote heating process, which means precise localization of the MNPs and real-time thermal feedback into the treated tissue.…”