The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets

Qi, Renli; Sun, Jing; Qiu, Xiaoyu; Zhang, Yong; Wang, Jing; Wang, Qi; Huang, Jinxiu; Ge, Liangpeng; Liu, Zuohua

doi:10.1038/s41598-021-90881-5

Cited by 28 publications

(37 citation statements)

References 73 publications

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“…Wildlife is more vulnerable to the threat of diarrhea due to the lack of timely, effective veterinary intervention. Studies have confirmed that the gut microbiome plays an important role in host growth, development, and immune response (35,36). Changes in the gut microbial community not only lead to gastrointestinal diseases, such as metabolic syndrome, obesity, and diarrhea (37,38), but also cause diseases outside the digestive system, including central nervous system disorders (39), cardiovascular disease (40), etc.…”

Section: Discussionmentioning

confidence: 98%

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Qin

Song

et al. 2021

Front. Vet. Sci.

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The structure and composition of gut microbiota correlate with the occurrence and development of host health and disease. Diarrhea can cause alterations in gut microbiota in animals, and the changes in the gut microbial structure and composition may affect the development of diarrhea. However, there is a scarcity of information on the effects of diarrhea on gut fungal composition and structure, particularly in Baer's pochard (Aythya baeri). The current study was performed for high-throughput sequencing of the fungal-specific internal transcribed spacer 1 (ITS-1) to detect the differences of gut mycobiota in healthy and diarrheal Baer's pochard. Results showed that the gut mycobiota not only decreased significantly in diversity but also in structure and composition. Statistical analysis between two groups revealed a significant decrease in the abundance of phylum Rozellomycota, Zoopagomycota, Mortierellomycota, and Kickxellomycota in diarrheal Baer's pochard. At the genus levels, fungal relative abundance changed significantly in 95 genera, with 56 fungal genera, such as Wickerhamomyces, Alternaria, Penicillium, Cystofilobasidium, and Filobasidium, increasing significantly in the gut of the diarrheal Baer's pochard. In conclusion, the current study revealed the discrepancy in the gut fungal diversity and community composition between the healthy and diarrheal Baer's pochard, laying the basis for elucidating the relationship between diarrhea and the gut mycobiota in Baer's pochard.

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Section: Discussionmentioning

confidence: 98%

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Qin

Song

et al. 2021

Front. Vet. Sci.

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“…In addition to the heart, autophagy might be regulated by the gut microbiota in other muscles. Recently, high-throughput RNA-seq analysis revealed that the expression levels of autophagy-related genes ( LC3A , LC3B , and Beclin-1 ) were modulated in the skeletal muscles of germ-free piglets compared to control piglets[ 79 ]. Moreover, germ-free piglets harbored decreased expression of mTOR and AKT and their phosphorylated forms, phospho-mTOR (S2448) and phospho-AKT (S473), respectively, compared to control piglets[ 79 ].…”

Section: Systemic Effects Of the Gut Microbiota On Host Autophagymentioning

confidence: 99%

“…Recently, high-throughput RNA-seq analysis revealed that the expression levels of autophagy-related genes ( LC3A , LC3B , and Beclin-1 ) were modulated in the skeletal muscles of germ-free piglets compared to control piglets[ 79 ]. Moreover, germ-free piglets harbored decreased expression of mTOR and AKT and their phosphorylated forms, phospho-mTOR (S2448) and phospho-AKT (S473), respectively, compared to control piglets[ 79 ]. FMT of germ-free piglets with stools collected on healthy donors pigs was effective in restoring the amounts of phospho-AKT and mTOR to a level similar to that of controls[ 79 ].…”

Section: Systemic Effects Of the Gut Microbiota On Host Autophagymentioning

confidence: 99%

“…Moreover, germ-free piglets harbored decreased expression of mTOR and AKT and their phosphorylated forms, phospho-mTOR (S2448) and phospho-AKT (S473), respectively, compared to control piglets[ 79 ]. FMT of germ-free piglets with stools collected on healthy donors pigs was effective in restoring the amounts of phospho-AKT and mTOR to a level similar to that of controls[ 79 ]. Some microbial-derived metabolites able to influence the muscle autophagy have been identified.…”

Section: Systemic Effects Of the Gut Microbiota On Host Autophagymentioning

confidence: 99%

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Reciprocal interactions between gut microbiota and autophagy

Lapaquette¹,

Bizeau²,

Acar³

et al. 2021

WJG

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A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution, forming an interkingdom consortium. The gut offers a favorable ecological niche for microbial communities, with the whole body and external factors ( e.g. , diet or medications) contributing to modulating this microenvironment. Reciprocally, the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other organs. However, failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or progression. Several microbial and host processes are devoted to facing up the stress that could alter the symbiosis, ensuring the resilience of the ecosystem. Among these processes, autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and homeostasis. This cytoprotective mechanism, which is ubiquitous and operates at basal level in all tissues, can be rapidly down- or up-regulated at the transcriptional, post-transcriptional, or post-translational levels, to respond to various stress conditions. Because of its sensitivity to all, metabolic-, immune-, and microbial-derived stimuli, autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host responses. In this review, we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral organs. Then, we describe the autophagy-related mechanisms affecting the gut microbiota. We conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

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“…Many studies concerning meat quality have shown that muscle glycogen utilization, protein denaturation, degradation of muscle, and muscle fiber diameter and density affected the pH, water-holding capacity, and shearing force of meat ( 13 – 15 ). Additional studies concerning the gut microbiota-muscle axis showed that gut microbiota contributed to growth and the physiological state of muscle tissue ( 16 ), the substance and energy metabolism of muscle ( 17 ), as well as the synthesis and function of skeletal muscle ( 18 ). Therefore, the intestinal microbiota could be strategically regulated to improve meat quality through the muscle-gut microbiota axis.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Microbiota Regulate Certain Meat Quality Parameters in Chicken

et al. 2022

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Growing evidence of intestinal microbiota-muscle axis provides a possibility to improve meat quality of broilers through regulating intestinal microbiota. Water-holding capacity is a crucial factor to evaluate the meat quality. High quality of water-holding capacity is usually described as a low drip-losing rate. This study aimed to explore the relationship between intestinal microbiota and water-holding capacity of muscle in broilers. According to our results, two native breeds of broilers (the Arbor Acres broilers and the Beijing-You broilers) exhibited remarkable differences in microbiota composition. However, the regular of gut bacteria compositions gradually became similar when the two breeds of broiler were raised in a same feeding environment. Therefore, this similar regular of intestinal microbiota induced similar water-holding capacity of the muscle from the two breeds. In subsequent fecal microbiota transplantation (FMT) experiments, the intestinal microbiota community of the Arbor Acres broilers was remodeling by oral gavage of bacterial suspension that was derived from the Beijing-You broilers. Then, not only body weight and abdominal fat rate were increased, but also drip loss of muscle was decreased in the Arbor Acres broilers. Additionally, muscle fiber diameter of biceps femoris muscle and expression of MyoD1 were notably enlarged. Muscle fiber diameter and related genes were deemed as important elements for water-holding capacity of muscle. Simultaneously, we screened typical intestinal bacteria in both the two native breeds of broilers by 16S rDNA sequencing. Lachnoclostridium was the only bacteria genus associated with drip-losing rate, meat fiber diameter, body weight, and abdominal fat rate.ImportanceHigher body weight and superior meat quality in livestock imply an adequate source of protein and substantial commercial value. Regulating the intestinal microbiota of broilers is a promising approach to optimize commercial phenotypes. Our results indicate that the intestinal microbiota profile could be reconstructed by external factors, leading to advantageous changes in muscle characteristics. The cecum microbiota of native broilers have the ability to improve certain meat quality and production performance. The population of Lachnoclostridium spp. could be used to regulate body weight and drip-losing rate in broilers, but more study is needed.

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The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets

Cited by 28 publications

References 73 publications

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Reciprocal interactions between gut microbiota and autophagy

Intestinal Microbiota Regulate Certain Meat Quality Parameters in Chicken

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