The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease

Huang, Yinghui; Wang, Xin; Xiong, Jiachuan; Yao, Mengying; Zhang, Bo; Zhao, Jinghong

doi:10.3389/fphar.2022.837500

Cited by 30 publications

(26 citation statements)

References 165 publications

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Section: Introductionmentioning

confidence: 99%

“…Recently, a close interaction between the microbiota and mitochondria has been comprehensively described in multiple diseases (18)(19)(20)(21). Gut microbiota and their metabolites play vital roles in mitochondrial biogenesis, metabolism, and oxidative stress (18). However, the specific mechanisms by which the cross-talk between microbiota and mitochondria contributes to the progression of NAFLD are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

et al. 2022

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The increasing prevalence of non-alcoholic fatty liver disease (NAFLD), which is a progressive disease, has exerted huge a healthcare burden worldwide. New investigations have suggested that the gut microbiota closely participates in the progression of NAFLD through the gut–liver axis or gut–brain–liver axis. The composition of the microbiota can be altered by multiple factors, primarily dietary style, nutritional supplements, or exercise. Recent evidence has revealed that gut microbiota is involved in mitochondrial biogenesis and energy metabolism in the liver by regulating crucial transcription factors, enzymes, or genes. Moreover, microbiota metabolites can also affect mitochondrial oxidative stress function and swallow formation, subsequently controlling the inflammatory response and regulating the levels of inflammatory cytokines, which are the predominant regulators of NAFLD. This review focuses on the changes in the composition of the gut microbiota and metabolites as well as the cross-talk between gut microbiota and mitochondrial function. We thus aim to comprehensively explore the potential mechanisms of gut microbiota in NAFLD and potential therapeutic strategies targeting NAFLD management.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

et al. 2022

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“…To map adaptations to carbohydrates that are growth dependent and independent, we systematically compared the response to metabolic stress in microaerophilic (CO 2 enriched environments) >3% CO 2 ) conditions of the five probiotic Lactobacillaceae species: Lacticaseibacillus rhamnosus GG (15), Lacticaseibacillus casei (16), Lactobacillus acidophilus (17), Lacticaseibacillus paracasei , and Lactiplantibacillus plantarum (18) during planktonic growth and colony biofilm formation. Bacillus coagulans , a probiotic Bacilli belonging to the same phylum(19), was studied as a non-Lactobacillaceae LAB control strain.…”

Section: Introductionmentioning

confidence: 99%

Context-dependent differences in the functional responses of Lactobacillaceae strains to fermentable sugars

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et al. 2022

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Lactobacillaceae are Gram-positive rods, facultative anaerobes, and belong to the lactic acid bacteria (LAB) that frequently serve as probiotics. We systematically compared five LAB strains for the effects of different carbohydrates on their free-living and biofilm lifestyles. We found that fermentable sugars triggered a heterogeneous response in LAB strains, frequently manifested specifically in altered carrying capacity during planktonic growth and colony development. The fermentation capacities of the strains were compatible and could not account for heterogeneity in their differential carrying capacity in liquid and on a solid medium. Among tested LAB strains, L. paracasei, and L. rhamanosus GG survived self-imposed acid stress while L. acidophilus was extremely sensitive to its own glucose utilization acidic products. The addition of a buffering system during growth on a solid medium significantly improved the survival of most tested probiotic strains during fermentation. We suggest that the optimal performance of the beneficial microbiota members belonging to lactobacilli is heterogeneous and varies as a function of the growth model and the dependency on a buffering system.

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“…Traditional Chinese medicine reveals that chronic renal failure is located in the spleen and kidney, and the pathogenesis can be summarized as deficiency of the yang qi of spleen, while kidney is the cause and the internal stagnation of dampness, turbidity, stasis and toxin is the symptom (Liu et al, 2014). Recently, traditional Chinese medicine suggests that herbal medicines that are capable of invigorating the spleen and kidney, promoting blood circulation, and removing turbidity may be effective in the treatment of CKD and renal fibrosis (Zhao et al, 2022). Scutellaria baicalensis Georgi (SB), a traditional Chinese medicine, has been prescribed to treat diseases in China for thousands of years, such as inflammation (Guan et al, 2020) and fibrosis (Kong et al, 2011;Pan et al, 2012), even though the mechanism remains elusive.…”

Section: Introductionmentioning

confidence: 99%

“…Mitochondrial damage in proximal tubule cells has gradually evolved as a feature of various forms of AKI (Parikh et al, 2015;Sun et al, 2019). Accumulating evidences, including ours, suggested mitochondrial injury as a major contributor to acute and chronic kidney disease (Huang et al, 2020a;Huang et al, 2020b;Yu et al, 2020;Huang et al, 2022). Therefore, exploring therapeutic strategies aimed at restoring mitochondrial homeostasis may hold great potential for improving renal function (Emma et al, 2016;Bhargava and Schnellmann, 2017;Sun et al, 2019;Tang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis

et al. 2022

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Background: Acute kidney injury (AKI) occurs in approximately 7–18% of all hospitalizations, but there are currently no effective drug therapy for preventing AKI or delaying its progression to chronic kidney disease (CKD). Recent studies have shown that Scutellaria baicalensis, a traditional Chinese herb, could attenuate cisplatin-induced AKI, although the mechanism remains elusive. Further, it is unknown whether its major active component, Oroxylin A (OA), can alleviate kidney injury.Methods: The therapeutic effect of OA was evaluated by using ischemia-reperfusion (IR) and cisplatin mediated-AKI mice and HK-2 cells under hypoxia-reoxygenation (HR) conditions. HE staining, transmission electron microscopy, flow cytometry, immunofluorescence, qPCR, Western blot, PPARα inhibitor, BNIP3 siRNA and ChIP assay were used to explore the role and mechanism of OA in AKI.Results: OA ameliorated tubular damage and dramatically decreased serum creatinine (Scr) and urea nitrogen (BUN), and the expressions of renal injury markers (Kim-1, Ngal) in AKI mice induced by both IR injury and cisplatin, as well as attenuating AKI-to-CKD transition. In vitro experiments showed that OA alleviated HR-induced mitochondrial homeostasis imbalance in renal tubular epithelial cells. Mechanistically, OA dose-dependently induced the expression of Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3), while knockdown of BNIP3 expression reversed the protection of OA against HR-mediated mitochondrial injury. Network pharmacological analysis and experimental validation suggested that OA enhanced BNIP3 expression via upregulating the expression of peroxisome proliferator activated receptor alpha (PPARα), which induced the transcription of BNIP3 via directly binding to its promoter region. Both in vitro and in vivo experiments confirmed that the renoprotective effect of OA was dramatically reduced by GW6471, a PPARα antagonist.Conclusion: Our findings revealed that OA ameliorates AKI-to-CKD transition by maintaining mitochondrial homeostasis through inducing PPARα-BNIP3 signaling pathway, indicating that OA may serve as a candidate therapeutic strategy for alleviating AKI and CKD.

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The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease

Cited by 30 publications

References 165 publications

Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

Gut microbiota–mitochondrial inter-talk in non-alcoholic fatty liver disease

Context-dependent differences in the functional responses of Lactobacillaceae strains to fermentable sugars

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis

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