The interstitial cells of the mammalian ovary: Felis domestica

Kingsbury, B. F.

doi:10.1002/aja.1000160103

Cited by 34 publications

(5 citation statements)

References 21 publications

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“…Interstitial cells within the mammalian ovary are not static components [ 31 ]. They differentiate from stromal fibroblasts, either independently (primary) or when they become associated with growing follicles [ 2 , 32 ] and they revert to this cell type, either independently or following follicle atresia [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Growth and development of the ovary and small follicle pool from mid fetal life to pre-puberty in the African elephant (Loxodonta africana)

Stansfield

Nöthling

Allen³

2012

BMC Vet Res

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BackgroundFollicle numbers and developing ovarian morphology, particularly with reference to the presence of interstitial tissue, are intimately linked within the ovary of the African elephant during the period spanning mid-gestation to puberty. These have not been previously quantified in any studies. The collection of 7 sets of elephant fetal ovaries between 11.2 and 20.2 months of gestation, and 29 pairs of prepubertal calf ovaries between 2 months and 9 years of age during routine management off-takes of complete family groups in private conservancies in Zimbabwe provided an opportunity for a detailed study of this period.ResultsThe changing morphology of the ovary is described as the presumptive cortex and medulla components of the fetal ovary settled into their adult form. Interstitial tissue dominated the ovary in late fetal life and these cells stained strongly for 3β–hydroxysteroid dehydrogenase. This staining continued postnatally through to 4.5 years of age suggesting continued secretion of progestagens by the ovary during this period. The considerable growth of antral follicles peaked at 28% of ovarian volume at around 16.7 months of fetal age. The numbers of small follicles (primordial, early primary and true primary), counted in the cortex using stereological protocols, revealed fewer small follicles in the ovaries of animals aged 0 to 4.5 years of age than during either late fetal life or prepubertal life.ConclusionsThe small follicle populations of the late-fetal and prepubertal ovaries of the African elephant were described along with the changing morphology of these organs. The changes noted represent a series of events that have been recorded only in the elephant and the giraffe species to date. The expansion of the interstitial tissue of the fetal ovary and its continued presence in early post natal life may well contribute to the control of follicle development in these early years. Further research is required to determine the reasons behind the variation of numbers of small follicles in the ovaries of prepubertal calves.

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Section: Discussionmentioning

confidence: 99%

Growth and development of the ovary and small follicle pool from mid fetal life to pre-puberty in the African elephant (Loxodonta africana)

Stansfield

Nöthling

Allen³

2012

BMC Vet Res

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“…Circum¬ stantial evidence suggests transformation of one cell type to another (Rasmussen, 1918;Kingsbury, 1914Kingsbury, , 1940Stafford & Mossman, 1945;Duke, 1949;Mossman & Judas, 1949;Eckstein, 1962), though this deduction is not rigorous when judged by dead and fixed tissue (Zuckerman, 1956). Furthermore, coupled with the potential capacity for interchangeability, ovarian cells share, with those of the adrenal cortex, the property of the synthesis of steroids.…”

Section: Discussionmentioning

confidence: 39%

The Ovary of the 13-Lined Ground Squirrel (Citellus Tridecemlineatus Mitchell) After Adrenalectomy

Ic¹,

Iw²

1963

Journal of Endocrinology

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This paper gives an account of a re-investigation of the work of Groat (1943Groat ( , 1944. It shows that, apart from animals dying from extraneous causes, the female ground squirrel in anoestrus, some 5 weeks after adrenalectomy, is in good condition, grows, prefers tap-water, and has electrolyte concentrations in blood and muscle similar to those of control animals. In the absence of the adrenals, new tissue appears in the ovaries and, more rarely, in extra-ovarian sites, and reasons are given for considering it to be adrenocortical both in form and function. The origin of this presumptive adrenocortical tissue and the implications of its formation are discussed.

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“…It is unlikely that they are derived either from the germinal epithelium, the granulosa and theca interna cells, or from the rete ovarii. The problem of the origin of interstitial cells is difficult and previous writers have suggested that almost every tissue cell of the gonad, including nervous tissue, may give rise to them (Kingsbury, 1914;Gillman, 1948). The presence of groups of small round cells resembling lymphocytes and of cells intermediate between them and fullydeveloped interstitial cells suggests that the small round cells may be their precursors.…”

Section: Foetal Gonads and Reproductive Organsmentioning

confidence: 99%

Reproductive and endocrine organs of foetal, newborn and adult seals

Amoroso

Bourne

Harrison

et al. 1965

Proceedings of the Zoological Society of London

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During late foetal life and at birth the gonads of both Grey and Common seals are enlarged, and there are indications of stimulation in the rest of the reproductive tract. The enlargement of the gonads is due mainly to the presence of very large numbers of cells resembling interstitial cells. The presence of groups of small round cells resembling lymphocytes and of cells intermediate between them and fully developed interstitial cells suggests that the small round cells may be the precursors of the latter. Whether these cells are lymphocytes or primitive mesenchymal cells cannot be stated with certainty. The ovaries of foetal Common and Grey seals contain no follicles beyond the stage where oocytes are ensheathed in a single layer of epithelial cells, but more marked follicular development was present in the ovaries of a still‐born Californian sea lion. No evidence of spermatogenesis was seen in the testes of any foetal or neonatal male seal. Regression occurs rapidly after birth and is nearly complete at the age of two weeks. The interstitial cells disappear by a process similar to fatty degeneration. Retrogression is accompanied by a remarkable obliteration of many blood vessels supplying the outer part of the medulla and the cortex of the ovary. The stimulus responsible for the precocious enlargement of the foetal gonads is removed with the birth of the young. The rapid decrease of endocrine influence after birth suggests that the placenta may be implicated. In the adult Common and Grey seal the corpus luteum persists until the end of pregnancy and begins to degenerate a few days after parturition. Follicular development occurs in the maternal ovaries towards the end of pregnancy and in the immediate post‐parturient period. The maternal ovaries are probably a source of oestrogens, both before, during, and after parturition, and such oestrogens could cross the placenta and affect foetal tissues. The prostate of all male foetuses of both species towards the end of pregnancy and immediately after birth is markedly enlarged. There is proliferation and hypertrophy of the prostatic alveoli, dilation of the tubules, and an increase in the size of the epithelial cells. A week after birth the weight of the gland is reduced by more than one‐half. Persistence and hyperplasia of the uterus masculinus occurs in some foetal and newborn pups of the Common seal, but no similar enlargement was seen in the Grey seal. The thyroid in the late foetal and neonatal Common and Grey seals showed wide differences in their histological appearances. The thyroid glands from an adult lactating seal of each species were widely different. In the Grey seal it was almost completely atropic but in the Common seal it appeared to be intensely active. The amount of medulla present in the adrenal of foetal seals is small by comparison with that of the cortex. A large number of cortical islands packed with lipid is present in the medulla, often containing more lipid than the cortex itself. The capsule of the adrenal varies considerably in thickness ...

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The interstitial cells of the mammalian ovary: Felis domestica

Cited by 34 publications

References 21 publications

Growth and development of the ovary and small follicle pool from mid fetal life to pre-puberty in the African elephant (Loxodonta africana)

Growth and development of the ovary and small follicle pool from mid fetal life to pre-puberty in the African elephant (Loxodonta africana)

The Ovary of the 13-Lined Ground Squirrel (Citellus Tridecemlineatus Mitchell) After Adrenalectomy

Reproductive and endocrine organs of foetal, newborn and adult seals

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