The Ovary of the 13-Lined Ground Squirrel (Citellus Tridecemlineatus Mitchell) After Adrenalectomy

Ic, Jones; Iw, Henderson

doi:10.1677/joe.0.0260265

Cited by 12 publications

(2 citation statements)

References 27 publications

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“…In the opossum Trichosurus vulpécula (Anderson, 1937;Reid & McDonald, 1968) and the quokka (Buttle, Kirk & Waring, 1952) the adrenals are essential to life, but this is apparently not so in the opossum, Didelphis virginiana (Britton & Silvette, 1937) or the palm squirrel, Funambulus pennanti (Prasad, Dhaliwal, Seth, Reddi, Silvashankar & Uberoi, 1966), and 'extra adrenal tissue' appeared in the ovaries of the latter species after adrenalectomy. Chester Jones & Henderson (1963) described similar adrenal-like tissue in the ovary of the adrenalectomized ground squirrel, Citellus tridecemlineatus. Recently (in collabora¬ tion with Dr G. P. Vinson, St Bartholomew's Hospital, London), analyses of plasma from hypophysectomized wallabies have shown very low cortisol levels (0-5 ng/ml as compared with 3-5 ng/ml in the intact controls).…”

Section: Haematocritmentioning

confidence: 99%

Hypophysectomy of the Tammar Wallaby, Macropus Eugenii: Surgical Approach and General Effects

Hearn¹

1975

Journal of Endocrinology

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A technique of hypophysectomy and regimes of pre- and post-operative care were developed for the tammar wallaby, Macropus eugenii, to a stage when animals can survive the operation with little apparent stress. Thyroid and adrenal gland weights declined after hypophysectomy, especially within the first 20-30 days. Changes in the adrenal cortex after hypophysectomy suggested that this region may have a zonal organization different from that in eutherian mammals. The reproductive tracts of males and females lost weight rapidly after hypophysectomy. Eleven plasma parameters were studied for the effects of hypophysectomy. There was a reduction in sodium and chloride and a tendency to higher potassium levels, reflecting inadequate adrenal cortical function. Calcium and total protein values remained unaffected, but inorganic phosphate, glucose and cholesterol were depleted, and a less significant depletion in blood urea, nitrogen and uric acid was evident.

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Section: Haematocritmentioning

confidence: 99%

Hypophysectomy of the Tammar Wallaby, Macropus Eugenii: Surgical Approach and General Effects

Hearn¹

1975

Journal of Endocrinology

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“…This may reflect the common embryological origin of the two glands (cf. Parkes, 1927) but the converse, corticosteroid synthesis, is not usually ascribed to the ovary, although the possibility exists (Chester Jones & Henderson, 1963). The functional significance of adrenal oestrogens is not known and they may normally be absent or occur only in trace amounts in the human being (Engel, 1962 ;Engel & Dimoline, 1963).…”

Section: Presumptive 17-anda\oestriolmentioning

confidence: 99%

The in Vitro Production of Oestrogens From Progesterone by Mouse Adrenal Glands

Gp¹,

Ic²

1964

Journal of Endocrinology

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The capacity of the adrenal gland of the mouse to form steroids in vitro, using incubation techniques with [4-14C]progesterone, was investigated.Reasons are given for the identification of two oestrogens, 16-oxooestrone and 17-epioestriol and two adrenocorticosteroids, corticosterone and 20\g=a\-hydroxycorticosterone. The presence or absence of the X zone did not appear to influence the relative amounts of oestrogens and adrenocorticosteroids produced. No compounds which could be unequivocally characterized as androgens (C19 steroids) were found.

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Differentiation of adrenal cortex‐like tissue at the hilum of the gonads in response to adrenalectomy

1966

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Following bilateral adrenalectomy, the adrenal cortex-like cells which appear in the ovaries of the 13-lined ground squirrel are in close relationship to the epithelial remnants of the rete ovarii and the medullary cords. Identical cells form in the bilaterally adrenalectomized male around the efferent ductules of the testes.Histochemical tests on these periductular cells gave positive results with polarized light, Sudan Black stain, ultraviolet light, and the Schultz test -all comparable to normal adrenal cortex cells.Electron microscopic studies of the periductular cells showed them to have ultrastructural characteristics of a steroid secreting cell.Male and female animals adrenalectomized a year before and maintained on tap water died within four days when the gonads and adnexa were removed. Male animals adrenalectomized a year before and maintained on tap water survived actively for two weeks when the testicles were removed, provided that the efferent ductules and surrounding adrenal cortex-like cells were left in place. These animals died within four days after the adnexa were removed.The periductular cells were incubated with radioactively tagged progesterone which showed that these cells secrete corticosterone, the normal primary corticosteroid of this animal, and desoxycorticosterone which functions as a combination glucocorticoid and mineralocorticoid.

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The Ovary of the 13-Lined Ground Squirrel (Citellus Tridecemlineatus Mitchell) After Adrenalectomy

Cited by 12 publications

References 27 publications

Hypophysectomy of the Tammar Wallaby, Macropus Eugenii: Surgical Approach and General Effects

Hypophysectomy of the Tammar Wallaby, Macropus Eugenii: Surgical Approach and General Effects

The in Vitro Production of Oestrogens From Progesterone by Mouse Adrenal Glands

Differentiation of adrenal cortex‐like tissue at the hilum of the gonads in response to adrenalectomy

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