The interrelationships among albumin, nutrient intake, and inflammation in elderly recuperative care patients

Sullivan, Dennis H.; Johnson, Larry E.; Dennis, Richard A.; Roberson, Paula K.; Heif, Muhannad; Garner, Kimberly K.; Bopp, Melinda M.

doi:10.1007/s12603-010-0297-1

Cited by 25 publications

(22 citation statements)

References 15 publications

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“…According to the researches into the phenomenon of low-level of serum albumin in those diseases, abnormal metabolism of albumin led by inflammation response may be an important reason for that, as well as a low intake of albumin [19]. The mechanism is not clear yet, however, IL-6 and other inflammatory cytokines may play an important role in it [11, 18].…”

Section: Discussionmentioning

confidence: 99%

Serum albumin, a good indicator of persistent organ failure in acute pancreatitis

Zhang

et al. 2017

BMC Gastroenterol

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BackgroundTo evaluate the predictive value of serum albumin (ALB) for persistent organ failure (POF) in acute pancreatitis (AP).MethodsWe selected 158 patients with AP in this retrospective study from Jan.1st, 2015 to Dec.31st, 2015. Forty-six patients were diagnosed with POF. All the values of laboratory parameters were measured upon admission to hospital. And 48 h after admission, we examined serum albumin of each patient again, called ‘ALB2’. Uni-and multi-variate logistic regression were used to evaluate the impact of ALB to predict POF.ResultsThe median age of the whole population was 48 years and 53.8% were male. The admission-time albumin of AP patients with POF was distinctly lower than patients without POF (28.9 (25.3–33.1) g/L vs. 38.5 (34.0–40.1) g/L, p < 0.001). In uni-variate analysis, WBC, PT, GLU, LDH, ALB, ALB2, BUN, Ca, HDL-C and Ranson were significantly associated with POF. After multivariate regression, ALB remained an independent prognostic factor for POF in AP (OR: 0.748, 95%CI: 0.645–0.868; p < 0.05). The AUC for ALB is 0.873 (0.808, 0.938), even larger than that for Ranson, 0.845 (0.634, 0.913).ConclusionsWe identified serum albumin predictive to persistent organ failure in acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Serum albumin, a good indicator of persistent organ failure in acute pancreatitis

Zhang

et al. 2017

BMC Gastroenterol

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“…In the literature there is some evidence that ghrelin production and sensitivity is altered during aging, and it may be one of the potential explanations of the beginning of the phenomenon of anorexia of aging. Moreover, leptin and inflammation appear to be potential determinants of nutritional status [50], [51]. In our sample the lack of correlation between eating patterns and cytokines and ghrelin may be due to the large variability in measurements of circulating leptin and ghrelin concentrations, perhaps reflecting the heterogeneity of older persons living in different settings.…”

Section: Discussionmentioning

confidence: 77%

Anorexia and Eating Patterns in the Elderly

et al. 2013

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ObjectivesTo evaluate the change in eating habits occurring in community- dwelling and institutionalized elderly subjects with senile anorexia.DesignCross- sectional, observational.SettingCommunity, nursing homes and rehabilitation or acute care facilities in four Italian regions.Participants A random sample of 526 subjects, aged 65 years and older (217 free living individuals, 213 residents in nursing homes, and 93 patients in rehabilitation and acute wards).MeasurementsAll subjects underwent a multidimensional geriatric evaluation of: nutritional status, anthropometric parameters, health and cognitive status, depression, taste, chewing and swallowing function, and some hormones related to appetite. Diet variety was assessed, considering the frequency of consumption of different food groups (milk and dairy products; meat, fish, and eggs; cereals and derivatives; fruit and vegetables).ResultsIn anorexic elderly subjects the global food intake was reduced, and the eating pattern was characterized by the reduced consumption of certain food groups (“meat, eggs and fish” and “fruit and vegetables”) whereas the frequency of consumption of milk and cereals remained almost unchanged. Nutritional parameters were significantly better in normal eating subjects and correlated with diet variety.ConclusionBecause of the high prevalence of senile anorexia in the geriatric population and its impact on the nutritional status, further research should be prompted to establish an intervention. protocol allowing the early diagnosis of anorexia of aging, aimed at identifying its causes and at optimizing treatment of anorexic patients.

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“…Sullivan’s study found that inflammation appears to be a more powerful determinant of albumin, particularly CRP, and IL-6, and its change during the hospitalization than is nutrient intake in elderly patients admitted to a TCU [21]. Another study found, TNF-α, IL-10, and markers of oxidative stress were in negative correlation with HDL cholesterol and albumin.…”

Section: Discussionmentioning

confidence: 99%

A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α

et al. 2017

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BackgroundThis report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α.MethodsA total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-α of these subjects were investigated.ResultsThe morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-α levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-α levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-α levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-α, while VFA was the independent risk factor of IL-6.ConclusionsThe onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-α and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.

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The interrelationships among albumin, nutrient intake, and inflammation in elderly recuperative care patients

Cited by 25 publications

References 15 publications

Serum albumin, a good indicator of persistent organ failure in acute pancreatitis

Serum albumin, a good indicator of persistent organ failure in acute pancreatitis

Anorexia and Eating Patterns in the Elderly

A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α

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