The interrelationship between tubular and papillary sectors of tubulo-villous colorectal adenomas: Comparative morphometric analysis and evaluation of cell proliferation

Reissenweber, Nelson; Gualco, Gabrıela; Ardao, Gonzalo; Velazquez, Soledad; Kliche, Ivhanna; Fosman, E; Almeida, Edgardo

doi:10.1016/s0046-8177(98)90057-0

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The median AgNOR number in gastrointestinal cancers is believed to be higher in malignant lesions than benign lesions. 7,28 In the present study, the median AgNOR count differed significantly between the intramucosal carcinomas and each type of adenoma. However, the AgNOR number does not necessarily reflect cellular proliferation; if anything, it reflects protein synthesis.…”

Section: Discussionmentioning

confidence: 40%

“…The AgNOR count has been shown to be significantly different between benign and malignant tumors 7,28 and has been proposed as a diagnostic parameter for determining the grade of malignancy. The median AgNOR number in gastrointestinal cancers is believed to be higher in malignant lesions than benign lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, DNA ploidy, 2–4 cell proliferation 2,3,5 and p53 alteration 6 have also been applied to the differential diagnosis of histopathology in many organs. Previous studies on cell proliferation have already shown higher proliferation rates in carcinoma, 2,3,7 and DNA aneuploidy measured by flow cytometry 2,3,8 or p53 alteration determined by immunohistochemistry 9,10 may precede malignancy.…”

mentioning

confidence: 89%

“…Assessment of silver‐staining nucleolar organizer region (AgNOR) appears to yield similar information to that of the other indices of cellular proliferation, 2,3,7 although AgNOR staining has been claimed not to be of diagnostic value in tumor histopathology. 15,16 Furthermore, one study has shown that AgNOR staining does not correlate with other measures of proliferative activity.…”

mentioning

confidence: 99%

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Usefulness of proliferative activity, DNA ploidy pattern and p53 products as diagnostic adjuncts in colorectal adenomas and intramucosal carcinomas

Sugai

Nakamura

Habano

et al. 1999

Pathology International

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Although numerous studies have assessed the biologic parameters of tumors, measurement of these parameters has had, to date, little impact on histologic diagnosis. Furthermore, analysis of a single parameter is insufficient to evaluate tumor malignant potential. In the present study, cell proliferation, DNA ploidy and p53 product were analyzed to objectify the tumor malignant potential in colorectal adenomas and intramucosal carcinomas. Sixty-one adenomas and 49 intramucosal carcinomas were studied using immunohistochemical analysis of Ki-67 and p53, silver-staining nucleolar organizer region (AgNOR) stain and DNA ploidy in fresh samples. Intramucosal carcinoma exhibited a greater Ki-67-positive rate and AgNOR count than the adenomas, although these parameters varied widely among samples. The incidence of aneuploidy and p53 over-expression in colorectal intramucosal carcinomas was significantly higher than in colorectal adenomas. These results indicate that DNA aneuploidy and p53 accumulation are the most reliable parameters for distinguishing benign and malignant lesions.

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 99%