The interrelatedness of chronic cough and chronic pain

Arinze, Johnmary T.; Verhamme, Katia; Luik, Annemarie I.; Stricker, Bruno H.; Meurs, Joyce B. J. van

doi:10.1183/13993003.02651-2020

Cited by 24 publications

(31 citation statements)

References 35 publications

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“…Chronic cough is more prevalent in females than males, with studies reporting 66-73% of patients to be female [27,30]. This mirrors similar findings for chronic pain, and comorbid daily chronic pain and chronic cough, which are also more prevalent in women than in men [31], possibly due to shared neural pathways. Data from a functional magnetic resonance imaging study, involving inhalation of subtussive concentrations of capsaicin, suggest these gender prevalence effects may reflect differences in central neural processing of the cough sensation [27].…”

Section: Epidemiologysupporting

confidence: 53%

Chronic cough: new insights and future prospects

et al. 2021

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Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dysregulation. Chronic cough and RCC result in a serious, often unrecognized, disease burden, which forms the focus of the current review.The estimated global prevalence of chronic cough is 2–18%. Patients with chronic cough and RCC report many physical and psychological effects, which impair their quality of life. Chronic cough also has a significant economic burden for the patient and healthcare systems. RCC diagnosis and treatment are often delayed for many years as potential treatable triggers must be excluded first and a stepwise empirical therapeutic regimen is recommended.Evidence supporting most currently recommended treatments is limited. Many treatments do not address the underlying pathology, are used off-label, have limited efficacy and produce significant side-effects. There is therefore a significant unmet need for alternative therapies for RCC that target the underlying disease mechanisms. Early clinical data suggest that antagonists of the purinergic P2X3 receptor, an important mediator of RCC, are promising, though more evidence is needed.

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Section: Epidemiologysupporting

confidence: 53%

Chronic cough: new insights and future prospects

et al. 2021

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“…Consequently, our findings may not be generalizable to hospital-based cohorts. Fifth, chronic pain might be a major confounding factor in the chronic cough-depression link [40]. However, because we did not have chronic pain data during this study period in the Rotterdam Study, we could not adjust for it in our analyses.…”

Section: Discussionmentioning

confidence: 99%

The interrelationship of chronic cough and depression: a prospective population-based study

et al. 2022

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BackgroundChronic cough is a debilitating medical condition that is often complicated by psychomorbidities such as depressive symptoms. Nevertheless, little is known about the impact of chronic cough on the risk of developing depression. Therefore, we investigated the association between chronic cough and prevalent, incident, as well as recurrent depression in a population-based sample of middle-aged and older persons.MethodsWithin the Rotterdam Study, a population-based cohort, we defined chronic cough as reporting daily coughing for at least 3 months. Depression was assessed using the Center for Epidemiologic Studies–Depression scale, clinical interviews, and medical records. Associations between chronic cough and depression were determined with linear, logistic and Cox regression analyses.ResultsThe study included 5877 participants (mean age±standard deviation: 72±8 years, 59% female) who contributed 37 287 person-years of follow-up. At baseline, participants with chronic cough reported more depressive symptoms (adjusted standardised mean difference 0.15, 95% CI 0.07–0.22) compared to those without chronic cough. Over time, chronic cough was associated with an increased risk of depression in participants with a history of depression (HR 1.45, 95% CI 1.13–1.84) but not in those without a history of depression (HR 0.91, 95% CI 0.68–1.22).ConclusionsAdults with chronic cough have a disproportionate burden of depressive symptoms and an increased risk of recurrent depression. This highlights the importance of screening for depression in patients with chronic cough.

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“…Understanding chronic cough at a population level can also provide a different perspective and may identify other associated risk factors, for example, occupational exposure to dust/fumes 16 and chronic pain 39 . This study showed many other cardio-vascular and mental health conditions that were associated with a higher incidence of chronic cough in a population.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

et al. 2021

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The global prevalence of chronic cough(CC) is highly variable ranging from 2–18%. There is a lack of data on the prevalence and incidence of CC from the general population. The objective of this study was to investigate the prevalence and incidence of CC in a sample of Canadian adults, and how these influenced by age, sex, smoking, respiratory symptoms, medical co-morbidities, and lung function.Participants with chronic cough were identified from the Canadian Longitudinal Study on Ageing (CLSA) based on a self-reported daily cough in the last 12 months. This is a prospective, nationally generalisable, stratified random sample of adults aged 45–85 at baseline recruited between 2011–2015, and followed-up 3 years later. The prevalence and incidence per-100-person-years are described, with adjustments for age, sex and smoking.Of the 30 097 participants, 29 972 completed the CC question at baseline and 26 701 at follow-up. The prevalence of CC was 15.8% at baseline and 17.6% at follow-up with 10.4%–17.1% variation across 7 provinces included in the CLSA comprehensive sample. Prevalence increased with age, current smoking, and was higher in males(15.2%), Caucasians(14%), and those born in North America, Europe or Oceania(14%). The incidence of CC adjusted for age, sex and smoking was higher in males, underweight and obese. Respiratory symptoms, airways diseases, lower FEV1%predicted, cardio-vascular diseases, psychological disorders, diabetes and chronic pain had a higher incidence of CC.The prevalence and incidence of CC is high in the CLSA sample with geographic, ethnic and gender differences which is influence by a number of medical co-morbidities.

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The interrelatedness of chronic cough and chronic pain

Cited by 24 publications

References 35 publications

Chronic cough: new insights and future prospects

Chronic cough: new insights and future prospects

The interrelationship of chronic cough and depression: a prospective population-based study

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

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