The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: A cross-cultural perspective

Robertson, Mary M.; Eapen, Valsamma; Cavanna, Andrea E.

doi:10.1016/j.jpsychores.2009.07.010

Cited by 263 publications

(166 citation statements)

References 69 publications

(82 reference statements)

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“…According to the DSM-5, diagnostic criteria for TS focus on the presence of multiple motor tics plus at least one vocal tic, with onset before the age of 18 years and lasting for over a year [13]. Based on epidemiological studies mainly carried out in school-age children, TS is thought to affect between 0.3% and 0.9% of the population, with a male-to-female ratio of 3-4:1 [6,14,15]. Onset is typically in early childhood; one large multicenter study reported a mean age of onset of 6.4 years [16].…”

Section: Tourette Syndromementioning

confidence: 99%

Histaminergic modulation in Tourette syndrome

Cox

Seri

Cavanna

2016

Expert Opinion on Orphan Drugs

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Section: Tourette Syndromementioning

confidence: 99%

Histaminergic modulation in Tourette syndrome

Cox

Seri

Cavanna

2016

Expert Opinion on Orphan Drugs

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“…gard to their location, frequency and severity over time [2]. GTS affects approximately 1% of school-age youngsters and is three to four times more common in males than females [3]. GTS is increasingly recognised as a complex disorder, with a wide spectrum of associated behavioural problems that can accompany the motor and phonic tics.…”

mentioning

confidence: 99%

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Cavanna

David

Bandera

et al. 2013

Behavioural Neurology

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Abstract. Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterised by multiple motor and phonic tics and associated behavioural problems, carrying a significant burden on patients' lives. Although the term health related-quality of life (HR-QOL) has only been used in recent years, several studies have long addressed the impact of GTS on physical, psychological and social aspects of wellbeing of both children and adults with GTS. We set out to answer the question "Is HR-QOL affected by GTS and, if so, in what domains?" by conducting a systematic literature review of published original studies addressing HR-QOL in both children and adult patients with GTS. This review focuses on the current evidence on the impact of GTS on patients' lives, mainly informed by studies using generic functional impairment and HR-QOL measures from the last decade, and expands on the new opportunities introduced by the recently developed GTS-specific HR-QOL scales (GTS-QOL and GTS-QOL-C&A). Analysis of the first decade of studies specifically addressing HR-QOL in GTS suggests that co-morbid conditions are key factors in determining HR-QOL in young patients, whilst the picture is more complex in adults with GTS. These findings offer some general directions for both current clinical practice and future research. Keywords: Gilles de la Tourette syndrome, health-related quality of life, functional impairment, tics, behavioural problems The functional impact of Gilles de la Tourette syndrome across the lifespanGilles de la Tourette syndrome (GTS) is a life-long neurodevelopmental disorder defined by the presence of multiple motor and phonic tics [1]. Tics are repetitive, uncontrollable movements or vocalizations that usually present in childhood but may change with re- * Corresponding author: Dr. Andrea Eugenio Cavanna, MD, PhD., Department of Neuropsychiatry, The Barberry National Centre for Mental Health, 25 Vincent Drive, Birmingham B15 2FG, UK. Tel.: +44 0121 3012317; Fax: +44 0121 3012291; E-mail: cavanna77@tin.it. gard to their location, frequency and severity over time [2]. GTS affects approximately 1% of school-age youngsters and is three to four times more common in males than females [3]. GTS is increasingly recognised as a complex disorder, with a wide spectrum of associated behavioural problems that can accompany the motor and phonic tics. These problems include ticrelated symptoms (ranging from socially inappropriate statements to actual self-harm) and co-morbid psychiatric disorders, such as obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) [4,5]. Large studies conducted both in clinical populations [2,6] and in the community [7] have consistently found that only about 10% of individuals with GTS do not present with behavioural co-morbidities.

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“…Tic disorders and TS are common in children. Epidemiological studies show that the prevalence of TS is about 1% in school-age children in western countries, whereas only approximately 0.5% in Asian countries [1]. The etiology of TS attributes to be multifactorial including genetic, immunological and hormonal factors [2].…”

Section: Introductionmentioning

confidence: 99%

Association of Epilepsy and Tourette Syndrome in Children

Hung¹

2017

Epilepsy J

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Epilepsy is increasingly recognized as an important association with tic disorders and Tourette syndrome in children. Previous studies reported the overall prevalence of Tourette syndrome was around 1% in children. Epidemiological studies showed evidences of increased neuropsychiatric comorbidities of Tourette syndrome including attention-deficit hyperactivity disorder, obsessive-compulsive disorder and autistic spectrum disorder. The recent studies have demonstrated that increased risk of epilepsy in children with Tourette syndrome, and also increased risk of Tourette syndrome in epilepsy children. The genetic and clinical information refer to a common neurobiological basis for epilepsy and Tourette syndrome.

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The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: A cross-cultural perspective

Cited by 263 publications

References 69 publications

Histaminergic modulation in Tourette syndrome

Histaminergic modulation in Tourette syndrome

Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research

Association of Epilepsy and Tourette Syndrome in Children

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