Histaminergic modulation in Tourette syndrome

Cox, Joanna H.; Seri, Stefano; Cavanna, Andrea E.

doi:10.1517/21678707.2016.1128819

Cited by 25 publications

(6 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After activation, IκBα is degraded by IκB kinase complex, which drives NF-κB to transfer into the nucleus and induces transcription and expression of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. [21] In the present study, our findings showed that GA administration or tiapride treatment decreased the levels of P-NF-kBP65 and P-IkBa in striatum of TS rats.…”

Section: Consistent With Expectations Ga Could Decreased the Contentsupporting

confidence: 62%

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Long

Ruan

Mengjiao

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The aim is to study the effects of gastrodin (GA) on striatal inflammation and oxidative stress in rats with Tourette syndrome (TS). The rat model of TS was induced by 3,3′‐iminodipropionitrile. Behavioral tests were carried out by stereotype experiment. The concentrations of amino acid transmitters glutamic acid (Glu) and γ‐aminobutyric acid (GABA) in striatum were determined by high‐performance liquid chromatography. Superoxide dismutase (SOD) and malondialdehyde (MDA) in serum and striatum were detected by commercial kits. Cytokines in serum and striatum were detected by enzyme‐linked immunosorbent assay kits. Western blot analysis was used to detect striatum nuclear erythroid factor 2‐related factor 2 (Nrf‐2)/heme oxygenase‐1 (HO‐1)/high mobility group box 1 protein (HMGB1)/nuclear factor‐кB (NF‐кB) pathway‐related proteins. The expressions of Nrf‐2 and P‐NF‐кBp65 in striatum were detected by immunohistochemistry. Compared with the control group, the stereotype scores of rats in the model group significantly increased, and the contents of Glu and GABA in striatum obviously increased. GA significantly reduced the stereotype scores and decreased the contents of Glu and GABA. The levels of SOD in serum and striatum were decreased and the content of MDA in serum and striatum were increased compared with the control group, while GA significantly restored the changes. GA significantly adjusted Nrf‐2/HO‐1/HMGB1/NF‐кB pathway‐related proteins changes consistent with immunohistochemical changes. GA may protect striatum of rats with TS by regulating Nrf‐2/HO‐1/HMGB1/NF‐кB pathway protein changes in striatum.

show abstract

Section: Consistent With Expectations Ga Could Decreased the Contentsupporting

confidence: 62%

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Long

Ruan

Mengjiao

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Other biochemical pathways, including histaminergic neurotransmission and amino acid neurotransmission, are likely to be involved but have received relatively little attention until recently. 27 It was proposed that a disrupted excitatory/inhibitory balance in key circuits might underlie many neurodevelopmental disorders including TS. 28 – 30 Previous study has shown that JPZDD is a specific treatment for TS patients, reducing the frequency of spontaneous hyperkinesias and decreasing the content of dopamine, norepinephrine, and Glu.…”

Section: Discussionmentioning

confidence: 99%

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

Zhang

et al. 2016

NDT

View full text Add to dashboard Cite

BackgroundJian-Pi-Zhi-Dong Decoction (JPZDD) is a dedicated treatment of Tourette syndrome (TS). The balance of neurotransmitters in the cortico-striato-pallido-thalamo-cortical network is crucial to the occurrence of TS and related to its severity. This study evaluated the effect of JPZDD on glutamate (Glu) and γ-aminobutyric acid (GABA) and their receptors in a TS rat model.Materials and methodsRats were divided into four groups (n=12 each). TS was induced in three of the groups by injecting them with 3,3′-iminodipropionitrile for 7 consecutive days. Two model groups were treated with tiapride (Tia) or JPZDD, while the control and the remaining model group were gavaged with saline. Behavior was assessed by stereotypic score and autonomic activity. Striatal Glu and GABA contents were detected using microdialysis. Expressions of N-methyl-D-aspartate receptor 1 and GABAA receptor (GABAAR) were observed using Western blot and real-time polymerase chain reaction.ResultsTia and JPZDD groups had decreased stereotypy compared with model rats; however, the JPZDD group showed a larger decrease in stereotypy than the Tia group at a 4-week time point. In a spontaneous activity test, the total distance of the JPZDD and Tia groups was significantly decreased compared with the model group. The Glu levels of the model group were higher than the control group and decreased with Tia or JPZDD treatment. The GABA level was higher in the model group than the control group. Expressions of GABAAR protein in the model group were higher than in the control group. Treatment with Tia or JPZDD reduced the expression of GABAAR protein. In the case of the mRNA expression, only Tia reduced the expression of N-methyl-D-aspartate receptor 1, compared with the model group.ConclusionJPZDD could alleviate impairments in behavior and dysfunctional signaling by downregulating GABAAR in the striatum. We suggest that this acts to maintain the balance of Glu and GABA.

show abstract

“…Twin and family studies support a genetic contribution, although no single responsible gene has yet been identified (Paschou, 2013). Its underlying aetiology is thought to involve disruption to neurotransmission within cortico-striato-thalamo-cortical pathways (Serajee and Manhubul Huq, 2015), including dopaminergic, serotonergic, and histaminergic systems (Cox et al, 2015), with possible contributions from cholinergic (Xu et al, 2015) and inhibitory gammaaminobutyric acid pathways (Puts et al, 2015).…”

Section: Motor and Non-motor Aspects Of Tourette Syndromementioning

confidence: 99%

Sensory aspects of Tourette syndrome

Cox

Seri

Cavanna

2018

Neuroscience & Biobehavioral Reviews

Self Cite

View full text Add to dashboard Cite

Motor and vocal tics have long been recognised as the core features of Tourette syndrome (TS). However, patients' first-person accounts have consistently reported that these involuntary motor manifestations have specific sensory correlates. These sensory symptoms are often described as feelings of mounting inner tension ("premonitory urges") and are transiently relieved by tic expression. Multimodal hypersensitivity to external stimuli, perceived as triggers and/or exacerbating factors for specific tic symptoms, is also commonly reported by patients with TS. This article focuses on the rapidly expanding literature on the clinical and neurobiological aspects of the premonitory urge and multimodal hypersensitivity in patients with TS, with particular attention to pathophysiological mechanisms and possible treatment implications. These findings suggest that TS is a neurobehavioural condition characterised by intrinsic perceptual abnormalities involving the insula and sensorimotor areas, in addition to basal ganglia dysfunction. Further research will clarify the role of sensory symptoms in TS, as well as the effects of external sensory input on underlying motor abnormalities.

show abstract

Histaminergic modulation in Tourette syndrome

Cited by 25 publications

References 102 publications

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

Sensory aspects of Tourette syndrome

Contact Info

Product

Resources

About

Histaminergic modulation in Tourette syndrome

Cited by 25 publications

References 102 publications

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and &gamma;-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

Sensory aspects of Tourette syndrome

Contact Info

Product

Resources

About

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome