“…Particularly, the embryos of the zebrafish (Danio rerio) represent a highly attractive and versatile model, given their ease of production, size, transparency, rapid development, as well as well characterized developmental genetics and suitability for high throughput analysis. Potential applications in toxicology range from the prediction of acute fish (Belanger et al, 2013a;Knöbel et al, 2012a;Lammer et al, 2009) and fish early life stage toxicity (Volz et al, 2011), determination of bioconcentration (Kuhnert et al, 2013), analyses of endocrine disruption (Brion et al, 2012;Thienpont et al, 2011), identification of organ toxicity (Scholz, 2013), and teratogenic effects (Brannen et al, 2010;Gustafson et al, 2012;Selderslaghs et al, 2012) to prediction of mammalian acute systemic toxicity (Ali et al, 2011). Most advanced is the prediction of acute fish toxicity ((Lammer et al, 2009); (Belanger et al, 2013b); (Knöbel et al, 2012b)) indicated also by the recently approved OECD guideline TG 236 for the Fish Embryo Acute Toxicity Test (Busquet et al, 2014).…”